U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gvin1 GTPase, very large interferon inducible 1 [ Mus musculus (house mouse) ]

Gene ID: 74558, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Gvin1provided by MGI
Official Full Name
GTPase, very large interferon inducible 1provided by MGI
Primary source
MGI:MGI:1921808
See related
Ensembl:ENSMUSG00000045868 AllianceGenome:MGI:1921808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VLIG; Iigs1; VLIG-1; 9130002C22Rik; 9830104F22Rik
Summary
Predicted to enable GTP binding activity. Predicted to be located in cytosol and nucleus. Orthologous to human GVINP1 (GTPase, very large interferon inducible pseudogene 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in large intestine adult (RPKM 3.4), spleen adult (RPKM 2.8) and 23 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gvin1 in Genome Data Viewer
Location:
7 E3; 7 55.98 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105755742..105814547, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (106156535..106215340, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene GTPase, very large interferon inducible, pseudogene 3 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113288424-113288725 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene GTPase, very large interferon inducible, pseudogene 4 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113356789-113357089 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113357373-113357674 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113358882-113359183 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113359681-113359981 Neighboring gene STARR-positive B cell enhancer ABC_E4964 Neighboring gene STARR-positive B cell enhancer ABC_E2247 Neighboring gene STARR-seq mESC enhancer starr_19749 Neighboring gene STARR-positive B cell enhancer ABC_E8196 Neighboring gene STARR-positive B cell enhancer ABC_E10460 Neighboring gene STARR-positive B cell enhancer ABC_E10461 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113440593-113440894 Neighboring gene STARR-seq mESC enhancer starr_19750 Neighboring gene GTPase, very large interferon inducible, pseudogene 5 Neighboring gene GTPase, very large interferon inducible, pseudogene 6 Neighboring gene predicted gene, 22372

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A giant GTPase, very large inducible GTPase-1, is inducible by IFNs. Klamp T, et al. J Immunol, 2003 Aug 1. PMID 12874213
  2. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article
  3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
interferon-induced very large GTPase 1
Names
interferon inducible GTPase 1
very large-inducible GTPase-1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039160.2 → NP_001034249.2  interferon-induced very large GTPase 1

    See identical proteins and their annotated locations for NP_001034249.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two internal exons in the 5' UTR and encodes the same protein, compared to variant 1.
    Source sequence(s)
    AC165356
    Consensus CDS
    CCDS21663.1
    UniProtKB/TrEMBL
    L7N451
    Related
    ENSMUSP00000006667.4, ENSMUST00000006667.11
    Conserved Domains (3) summary
    PRK00247
    Location:72 → 139
    PRK00247; putative inner membrane protein translocase component YidC; Validated
    TIGR02168
    Location:1206 → 1432
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl38936
    Location:1485 → 1562
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_029000.3 → NP_083276.2  interferon-induced very large GTPase 1

    See identical proteins and their annotated locations for NP_083276.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC165356
    Consensus CDS
    CCDS21663.1
    UniProtKB/TrEMBL
    L7N451
    Related
    ENSMUSP00000138950.2, ENSMUST00000183409.2
    Conserved Domains (3) summary
    PRK00247
    Location:72 → 139
    PRK00247; putative inner membrane protein translocase component YidC; Validated
    TIGR02168
    Location:1206 → 1432
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl38936
    Location:1485 → 1562
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    105755742..105814547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312356.1 → XP_017167845.1  interferon-induced very large GTPase 1 isoform X1

    UniProtKB/TrEMBL
    L7N451
    Conserved Domains (3) summary
    PRK00247
    Location:72 → 139
    PRK00247; putative inner membrane protein translocase component YidC; Validated
    TIGR02168
    Location:1206 → 1432
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl38936
    Location:1485 → 1562
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80SU7.1 GenPept UniProtKB/Swiss-Prot:Q80SU7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools