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Ccdc7a coiled-coil domain containing 7A [ Mus musculus (house mouse) ]

Gene ID: 74703, updated on 2-Nov-2024

Summary

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Official Symbol
Ccdc7aprovided by MGI
Official Full Name
coiled-coil domain containing 7Aprovided by MGI
Primary source
MGI:MGI:1921953
See related
Ensembl:ENSMUSG00000025808 AllianceGenome:MGI:1921953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Biot2; Ccdc7; Gm3952; 100042659; 4930517G15Rik; 4930540C21Rik
Summary
Orthologous to human CCDC7 (coiled-coil domain containing 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 9.4) See more
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Genomic context

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See Ccdc7a in Genome Data Viewer
Location:
8 E2; 8 76.12 cM
Exon count:
59
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (129460715..129791973, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (128980019..129065492, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23105 Neighboring gene predicted gene, 26002 Neighboring gene integrin beta 1 (fibronectin receptor beta) Neighboring gene predicted gene, 26100 Neighboring gene STARR-seq mESC enhancer starr_23108 Neighboring gene STARR-positive B cell enhancer mm9_chr8:131465278-131465579 Neighboring gene predicted gene, 22545 Neighboring gene STARR-seq mESC enhancer starr_23110 Neighboring gene coiled-coil domain containing 7B Neighboring gene STARR-seq mESC enhancer starr_23111 Neighboring gene STARR-seq mESC enhancer starr_23112 Neighboring gene STARR-seq mESC enhancer starr_23113 Neighboring gene predicted gene, 22374 Neighboring gene STARR-seq mESC enhancer starr_23114 Neighboring gene STARR-seq mESC enhancer starr_23115 Neighboring gene zinc finger protein 1006

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNA interference of Biot2 induces G1 phase arrest and apoptosis in mouse colorectal cancer cell line. Zhou C, et al. Oncol Res, 2015. PMID 25706396, Free PMC Article
  2. [Analysis of expression pattern of a novel testis-highly expressed gene Biot2-L and the primary study on its role in testis development]. Wang H, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2009 Sep. PMID 19950598
  3. Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Satoh A, et al. Cell Metab, 2013 Sep 3. PMID 24011076, Free PMC Article
  4. Deficiency of Prdm13, a dorsomedial hypothalamus-enriched gene, mimics age-associated changes in sleep quality and adiposity. Satoh A, et al. Aging Cell, 2015 Apr. PMID 25546159, Free PMC Article
  5. RNA interference against Biot2, a novel mouse testis-specific gene, inhibits the growth of tumor cells. Wang CT, et al. Cell Mol Biol Lett, 2009. PMID 19277478, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. silencing Biot2 in CT26 cells by RNA interference can inhibit cell growth in vitro and in vivo.
    Title: RNA interference of Biot2 induces G1 phase arrest and apoptosis in mouse colorectal cancer cell line.
  2. Biot2-L was highly expressed in adult testis, and its expression increased regularly during testis development.
    Title: [Analysis of expression pattern of a novel testis-highly expressed gene Biot2-L and the primary study on its role in testis development].
  3. The Biot2 transcript was detected only and strongly in the testis tissues and abundantly in five types of murine cancer cell line.
    Title: RNA interference against Biot2, a novel mouse testis-specific gene, inhibits the growth of tumor cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Transgenic (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 7
Names
coiled-coil domain containing 7
putative cancer/testis antigen
testis-specific antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197041.1 → NP_001183970.1  coiled-coil domain-containing protein 7 isoform 2

    See identical proteins and their annotated locations for NP_001183970.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK015811, AK016006
    Consensus CDS
    CCDS57649.1
    UniProtKB/TrEMBL
    G3X9U4, Q9D4Y1
    Related
    ENSMUSP00000104379.3, ENSMUST00000108747.3
    Conserved Domains (1) summary
    pfam15368
    Location:1 → 148
    BioT2; Spermatogenesis family BioT2

  2. NM_001395237.1 → NP_001382166.1  coiled-coil domain-containing protein 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC104928, AC148114, AC156608, AC159993
    UniProtKB/TrEMBL
    A0A1L1SS82
    Related
    ENSMUSP00000149790.2, ENSMUST00000214889.2
    Conserved Domains (2) summary
    COG1196
    Location:105 → 429
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PTZ00108
    Location:1303 → 1659
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  3. NM_029061.3 → NP_083337.1  coiled-coil domain-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_083337.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
    Source sequence(s)
    AK015811, AK016006
    Consensus CDS
    CCDS40524.1
    UniProtKB/Swiss-Prot
    D3YY17, Q9D541
    UniProtKB/TrEMBL
    D3YVX2
    Related
    ENSMUSP00000092780.5, ENSMUST00000095158.11
    Conserved Domains (1) summary
    pfam15368
    Location:1 → 166
    BioT2; Spermatogenesis family BioT2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    129460715..129791973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D541.1 GenPept UniProtKB/Swiss-Prot:Q9D541

Gene LinkOut

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