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Mxra8 matrix-remodelling associated 8 [ Mus musculus (house mouse) ]

Gene ID: 74761, updated on 2-Nov-2024

Summary

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Official Symbol
Mxra8provided by MGI
Official Full Name
matrix-remodelling associated 8provided by MGI
Primary source
MGI:MGI:1922011
See related
Ensembl:ENSMUSG00000029070 AllianceGenome:MGI:1922011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asp3; Dicam; 1200013A08Rik; 1700095D18Rik
Summary
Involved in establishment of glial blood-brain barrier. Located in cell surface. Is expressed in brain ventricle and choroid plexus; cerebral cortex ventricular layer; heart valve; meninges; and skeleton. Orthologous to human MXRA8 (matrix remodeling associated 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 383.7), ovary adult (RPKM 167.8) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Mxra8 in Genome Data Viewer
Location:
4 E2; 4 87.58 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155924137..155928559)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155839680..155844102)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3560 Neighboring gene cyclin L2 Neighboring gene STARR-seq mESC enhancer starr_12275 Neighboring gene STARR-positive B cell enhancer ABC_E4740 Neighboring gene STARR-positive B cell enhancer ABC_E8042 Neighboring gene aurora kinase A interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10297 Neighboring gene dishevelled segment polarity protein 1 Neighboring gene taste receptor, type 1, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1671 Neighboring gene ceramide-1-phosphate transfer protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene expression profile of human chondrocyte HCS-2/8 cell line by EST sequencing analysis. Jung YK, et al. Gene, 2004 Apr 14. PMID 15087127
  2. Role of MXRA8 in Ross River Virus Disease Pathogenesis. Ng WH, et al. mBio, 2023 Apr 25. PMID 37036079, Free PMC Article
  3. DICAM in the Extracellular Vesicles from Astrocytes Attenuates Microglia Activation and Neuroinflammation. Han J, et al. Cells, 2022 Sep 24. PMID 36230938, Free PMC Article
  4. Ly6C(+) monocytes in the skin promote systemic alphavirus dissemination. Holmes AC, et al. Cell Rep, 2024 Mar 26. PMID 38446669, Free PMC Article
  5. Matrix remodeling-associated protein 8 is a marker of a subset of cancer-associated fibroblasts in pancreatic cancer. Ichihara R, et al. Pathol Int, 2022 Mar. PMID 35020975, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of MXRA8 in Ross River Virus Disease Pathogenesis.
    Title: Role of MXRA8 in Ross River Virus Disease Pathogenesis.
  2. DICAM in the Extracellular Vesicles from Astrocytes Attenuates Microglia Activation and Neuroinflammation.
    Title: DICAM in the Extracellular Vesicles from Astrocytes Attenuates Microglia Activation and Neuroinflammation.
  3. Matrix remodeling-associated protein 8 is a marker of a subset of cancer-associated fibroblasts in pancreatic cancer.
    Title: Matrix remodeling-associated protein 8 is a marker of a subset of cancer-associated fibroblasts in pancreatic cancer.
  4. Protective Role of Limitrin in Experimental Autoimmune Optic Neuritis.
    Title: Protective Role of Limitrin in Experimental Autoimmune Optic Neuritis.
  5. Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila.
    Title: Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila.
  6. Mxra8 bound directly to chikungunya virus particles and enhanced virus attachment and internalization into cells
    Title: Mxra8 is a receptor for multiple arthritogenic alphaviruses.
  7. These results indicate that DICAM acts as a negative regulator of osteoclast differentiation by suppressing the integrin alphaVbeta3 pathway.[DICAM]
    Title: DICAM inhibits osteoclast differentiation through attenuation of the integrin αVβ3 pathway.
  8. DICAM suppressed angiogenesis by attenuating AKT and p38 MAP kinase signalling.
    Title: DICAM inhibits angiogenesis via suppression of AKT and p38 MAP kinase signalling.
  9. Results indicate that DICAM, a novel dual Ig domain containing adhesion molecule, mediates cell adhesion via alphavbeta3 integrin.
    Title: DICAM, a novel dual immunoglobulin domain containing cell adhesion molecule interacts with alphavbeta3 integrin.
  10. new member of the transmembrane-type immunoglobulin superfamily and designated limitrin, localizing selectively to glia limitans in mouse brain
    Title: Limitrin, a novel immunoglobulin superfamily protein localized to glia limitans formed by astrocyte endfeet.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6)  1 citation
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC3047

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of glial blood-brain barrier IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
matrix remodeling-associated protein 8
Names
adipocyte-specific protein 3
dual Ig domain containing cell adhesion molecule
limitrin
matrix-remodeling-associated protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024263.4 → NP_077225.4  matrix remodeling-associated protein 8 precursor

    See identical proteins and their annotated locations for NP_077225.4

    Status: VALIDATED

    Source sequence(s)
    AK004732, AL670236, BQ033722
    Consensus CDS
    CCDS19044.1
    UniProtKB/Swiss-Prot
    Q76M97, Q920S7, Q9DBV4
    Related
    ENSMUSP00000030947.4, ENSMUST00000030947.4
    Conserved Domains (1) summary
    pfam07686
    Location:171 → 291
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155924137..155928559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539235.4 → XP_006539298.1  matrix remodeling-associated protein 8 isoform X1

    Conserved Domains (1) summary
    pfam07686
    Location:168 → 288
    V-set; Immunoglobulin V-set domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBV4.1 GenPept UniProtKB/Swiss-Prot:Q9DBV4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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