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Rrp7a ribosomal RNA processing 7 homolog A [ Mus musculus (house mouse) ]

Gene ID: 74778, updated on 2-Nov-2024

Summary

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Official Symbol
Rrp7aprovided by MGI
Official Full Name
ribosomal RNA processing 7 homolog Aprovided by MGI
Primary source
MGI:MGI:1922028
See related
Ensembl:ENSMUSG00000018040 AllianceGenome:MGI:1922028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kheg1; 1110014J01Rik
Summary
Predicted to enable RNA binding activity. Acts upstream of or within blastocyst formation. Located in cytoplasm. Is expressed in early conceptus and secondary oocyte. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to several human genes including RRP7A (ribosomal RNA processing 7 homolog A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in large intestine adult (RPKM 30.0), ovary adult (RPKM 26.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rrp7a in Genome Data Viewer
Location:
15 E1; 15 39.4 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83000047..83007002, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83115846..83122801, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Nfat activating molecule with ITAM motif 1 Neighboring gene STARR-positive B cell enhancer ABC_E7401 Neighboring gene STARR-positive B cell enhancer ABC_E3149 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:82873210-82873393 Neighboring gene predicted gene, 32620 Neighboring gene STARR-seq mESC enhancer starr_39309 Neighboring gene STARR-positive B cell enhancer ABC_E3150 Neighboring gene predicted gene, 41366 Neighboring gene STARR-positive B cell enhancer ABC_E7402 Neighboring gene serine hydrolase-like Neighboring gene polymerase (DNA-directed), delta interacting protein 3 Neighboring gene RNA U12, small nuclear

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of four genes required for mammalian blastocyst formation. Maserati M, et al. Zygote, 2014 Aug. PMID 23211737
  2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rrp7a is required for the blastocyst formation.
    Title: Identification of four genes required for mammalian blastocyst formation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to nucleolus IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosome biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of CURI complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of UTP-C complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ribosomal RNA-processing protein 7 homolog A
Names
gastric cancer antigen Zg14 homolog
kidney highly expressed protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358061.1 → NP_001344990.1  ribosomal RNA-processing protein 7 homolog A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL591952
    Conserved Domains (1) summary
    cd12294
    Location:59 → 153
    RRM_Rrp7A; RNA recognition motif in ribosomal RNA-processing protein 7 homolog A (Rrp7A) and similar proteins

  2. NM_029101.4 → NP_083377.3  ribosomal RNA-processing protein 7 homolog A isoform 1

    See identical proteins and their annotated locations for NP_083377.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK159553, BY280662, CO042481
    Consensus CDS
    CCDS27696.1
    UniProtKB/Swiss-Prot
    Q3TWT8, Q8CCK8, Q9D1C9
    UniProtKB/TrEMBL
    D3U0D6, Q3U5H9
    Related
    ENSMUSP00000018184.4, ENSMUST00000018184.10
    Conserved Domains (2) summary
    cd12951
    Location:151 → 280
    RRP7_Rrp7A; RRP7 domain ribosomal RNA-processing protein 7 homolog A (Rrp7A) and similar proteins
    cd12294
    Location:59 → 159
    RRM_Rrp7A; RNA recognition motif in ribosomal RNA-processing protein 7 homolog A (Rrp7A) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    83000047..83007002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D1C9.1 GenPept UniProtKB/Swiss-Prot:Q9D1C9

Gene LinkOut

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