WNT11 Wnt family member 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: WNT11provided by HGNC
Official Full Name: Wnt family member 11provided by HGNC
Primary source: HGNC:HGNC:12776
See related: Ensembl:ENSG00000085741 MIM:603699; AllianceGenome:HGNC:12776
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HWNT11
Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]
Expression: Broad expression in fat (RPKM 7.4), adrenal (RPKM 3.7) and 15 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.5

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (76186325..76210761, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (76116041..76140519, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (75897369..75917546, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gollop-Wolfgang Complex Is Associated with a Monoallelic Variation in WNT11.
Title: Gollop-Wolfgang Complex Is Associated with a Monoallelic Variation in WNT11.
Inhibition of Wnt11 impairs the osteogenesis and aggravates the inflammatory response of human mesenchymal stem cells under LPS-induced inflammatory condition.
Title: Inhibition of Wnt11 impairs the osteogenesis and aggravates the inflammatory response of human mesenchymal stem cells under LPS-induced inflammatory condition.
Cardiac Wnt5a and Wnt11 promote fibrosis by the crosstalk of FZD5 and EGFR signaling under pressure overload.
Title: Cardiac Wnt5a and Wnt11 promote fibrosis by the crosstalk of FZD5 and EGFR signaling under pressure overload.
Noncanonical Wnt Signaling Promotes Myofibroblast Differentiation in Pulmonary Fibrosis.
Title: Noncanonical Wnt Signaling Promotes Myofibroblast Differentiation in Pulmonary Fibrosis.
WNT11 is a direct target of early growth response protein 1.
Title: WNT11 is a direct target of early growth response protein 1.
WNT11-Conditioned Medium Promotes Angiogenesis through the Activation of Non-Canonical WNT-PKC-JNK Signaling Pathway.
Title: WNT11-Conditioned Medium Promotes Angiogenesis through the Activation of Non-Canonical WNT-PKC-JNK Signaling Pathway.
Aberrant expression of Wnt/beta-catenin signaling pathway genes in aggressive malignant gastric gastrointestinal stromal tumors.
Title: Aberrant expression of Wnt/β-catenin signaling pathway genes in aggressive malignant gastric gastrointestinal stromal tumors.
Investigated the role of Wnt11 in neuroendocrine (NE) differentiation, cell proliferation, and epithelial-to-mesenchymal transition in small-cell lung cancer (SCLC). Ascl1 plays an important role in regulating the Wnt signaling pathway and is one of the driver molecules of Wnt11 in SCLC. Wnt11 controlled NE differentiation, cell proliferation, and E-cadherin expression under the regulation of Ascl1 in SCLC cell lines.
Title: Ascl1-induced Wnt11 regulates neuroendocrine differentiation, cell proliferation, and E-cadherin expression in small-cell lung cancer and Wnt11 regulates small-cell lung cancer biology.
that ABHD11-AS1 promotes CRC progression through the miR-1254-WNT11 pathway
Title: Long noncoding RNA ABHD11-AS1 promote cells proliferation and invasion of colorectal cancer via regulating the miR-1254-WNT11 pathway.
WNT11 mRNA was present in three different human pancreatic ductal adenocarcinoma (PDAC) cell lines. WNT11 loss affected epithelial-mesenchymal transition, expression of neuronal and stemness biomarkers associated with metastasis. Human biopsies of PDAC showed significantly higher WNT11 mRNA levels compared with matched adjacent tissues. Upregulation of WNT11 expression ultimately worsens patient survival.
Title: Wnt-11 Expression Promotes Invasiveness and Correlates with Survival in Human Pancreatic Ductal Adeno Carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of PR interval. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wnt11 (e-PCR), detects polymorphism
- UniSTS:465417

NoName (e-PCR)
- UniSTS:490249

STS-W81325 (e-PCR)
- UniSTS:55151

SHGC-36303 (e-PCR)
- UniSTS:54646

NoName (e-PCR)
- UniSTS:481937

SGC44542 (e-PCR)
- UniSTS:25015

D11S2457 (e-PCR)
- UniSTS:20664

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway, calcium modulating pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in Wnt signaling pathway, planar cell polarity pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in adrenal gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in artery morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in atrial septum development	IEA Inferred from Electronic Annotation more info
involved_in bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info
involved_in bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in cloacal septation	IEP Inferred from Expression Pattern more info	PubMed
involved_in convergent extension involved in axis elongation	IEA Inferred from Electronic Annotation more info
involved_in embryonic skeletal system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in epithelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in lung-associated mesenchyme development	IEP Inferred from Expression Pattern more info	PubMed
involved_in maintenance of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info
involved_in mesenchymal cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in mesonephric duct development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cartilage development	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibroblast growth factor production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mesenchymal cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in neuroendocrine cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in notochord morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in paraxial mesoderm formation	IEA Inferred from Electronic Annotation more info
involved_in planar cell polarity pathway involved in axis elongation	IEA Inferred from Electronic Annotation more info
involved_in planar cell polarity pathway involved in gastrula mediolateral intercalation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein kinase C signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transforming growth factor beta2 production	IEA Inferred from Electronic Annotation more info
involved_in primary heart field specification	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nutrient levels	IEA Inferred from Electronic Annotation more info
involved_in secondary heart field specification	IEA Inferred from Electronic Annotation more info
involved_in secondary palate development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somite development	IEA Inferred from Electronic Annotation more info
involved_in stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in ureteric bud morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in ventricular septum morphogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-11

Names: wingless-type MMTV integration site family, member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.