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Purg purine-rich element binding protein G [ Mus musculus (house mouse) ]

Gene ID: 75029, updated on 2-Nov-2024

Summary

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Official Symbol
Purgprovided by MGI
Official Full Name
purine-rich element binding protein Gprovided by MGI
Primary source
MGI:MGI:1922279
See related
Ensembl:ENSMUSG00000049184 AllianceGenome:MGI:1922279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930486B15Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and purine-rich negative regulatory element binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is active in synapse. Is expressed in glossopharyngeal ganglion and midbrain mantle layer. Orthologous to human PURG (purine rich element binding protein G). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 7.5), CNS E14 (RPKM 5.3) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Purg in Genome Data Viewer
Location:
8 A3; 8 20.3 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (33875650..33907500)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33385619..33417472)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21100 Neighboring gene GTP-binding protein 10 (putative) pseudogene Neighboring gene STARR-seq mESC enhancer starr_21101 Neighboring gene Werner syndrome RecQ like helicase Neighboring gene STARR-seq mESC enhancer starr_21102 Neighboring gene STARR-seq mESC enhancer starr_21104 Neighboring gene STARR-seq mESC enhancer starr_21105 Neighboring gene translocase of outer mitochondrial membrane 40 homolog pseudogene Neighboring gene high mobility group box 1, related sequence 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation. Liu H, et al. Nucleic Acids Res, 2002 Jun 1. PMID 12034829, Free PMC Article
  2. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
  3. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087
  4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables purine-rich negative regulatory element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables purine-rich negative regulatory element binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
purine-rich element-binding protein gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098233.1 → NP_001091703.1  purine-rich element-binding protein gamma isoform b

    See identical proteins and their annotated locations for NP_001091703.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate 3' exon, compared to unspliced variant 1. This produces a unique 3' UTR, and the encoded isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC115809, AF479673, AI931378, BE648043, CD772246
    Consensus CDS
    CCDS52538.1
    UniProtKB/Swiss-Prot
    Q8R4E6
    Related
    ENSMUSP00000077205.4, ENSMUST00000078058.5
    Conserved Domains (1) summary
    pfam04845
    Location:60 → 293
    PurA; PurA ssDNA and RNA-binding protein

  2. NM_001382855.1 → NP_001369784.1  purine-rich element-binding protein gamma isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC115809
    UniProtKB/Swiss-Prot
    Q14B11, Q8R4E6, Q8R4E7
    Conserved Domains (1) summary
    pfam04845
    Location:60 → 324
    PurA; PurA ssDNA and RNA-binding protein

  3. NM_152821.2 → NP_690034.1  purine-rich element-binding protein gamma isoform a

    See identical proteins and their annotated locations for NP_690034.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is unspliced and encodes the longer isoform (a).
    Source sequence(s)
    AC115809, AF479673, AK015630
    Consensus CDS
    CCDS22230.1
    UniProtKB/Swiss-Prot
    Q14B11, Q8R4E6, Q8R4E7
    Related
    ENSMUSP00000065002.5, ENSMUST00000070340.6
    Conserved Domains (1) summary
    pfam04845
    Location:60 → 324
    PurA; PurA ssDNA and RNA-binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    33875650..33907500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154347.1 → XP_036010240.1  purine-rich element-binding protein gamma isoform X3

    Conserved Domains (1) summary
    pfam04845
    Location:60 → 295
    PurA; PurA ssDNA and RNA-binding protein

  2. XM_036154346.1 → XP_036010239.1  purine-rich element-binding protein gamma isoform X1

    Conserved Domains (1) summary
    pfam04845
    Location:60 → 295
    PurA; PurA ssDNA and RNA-binding protein

  3. XM_011242166.4 → XP_011240468.1  purine-rich element-binding protein gamma isoform X4

    See identical proteins and their annotated locations for XP_011240468.1

    Conserved Domains (1) summary
    pfam04845
    Location:60 → 292
    PurA; PurA ssDNA and RNA-binding protein

  4. XM_006509205.3 → XP_006509268.1  purine-rich element-binding protein gamma isoform X2

    Conserved Domains (1) summary
    pfam04845
    Location:60 → 292
    PurA; PurA ssDNA and RNA-binding protein

  5. XM_017312994.3 → XP_017168483.1  purine-rich element-binding protein gamma isoform X5

    Conserved Domains (1) summary
    pfam04845
    Location:60 → 297
    PurA; PurA ssDNA and RNA-binding protein

  6. XM_006509209.5 → XP_006509272.1  purine-rich element-binding protein gamma isoform X6

    See identical proteins and their annotated locations for XP_006509272.1

    UniProtKB/Swiss-Prot
    Q8R4E6
    Conserved Domains (1) summary
    pfam04845
    Location:60 → 293
    PurA; PurA ssDNA and RNA-binding protein

RNA

  1. XR_004934894.1 RNA Sequence

  2. XR_004934895.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4E6.1 GenPept UniProtKB/Swiss-Prot:Q8R4E6

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