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Mei4 meiotic double-stranded break formation protein 4 [ Mus musculus (house mouse) ]

Gene ID: 75033, updated on 2-Nov-2024

Summary

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Official Symbol
Mei4provided by MGI
Official Full Name
meiotic double-stranded break formation protein 4provided by MGI
Primary source
MGI:MGI:1922283
See related
Ensembl:ENSMUSG00000043289 AllianceGenome:MGI:1922283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930486G11Rik
Summary
Involved in meiotic DNA double-strand break formation. Acts upstream of or within homologous chromosome pairing at meiosis; oogenesis; and spermatogenesis. Located in lateral element. Is expressed in spermatocyte. Orthologous to human MEI4 (meiotic double-stranded break formation protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Mei4 in Genome Data Viewer
Location:
9 E1; 9 44.72 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (81745723..82088060)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (81863670..82206007)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D430036J16 gene Neighboring gene STARR-seq mESC enhancer starr_24767 Neighboring gene STARR-seq mESC enhancer starr_24768 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1B Neighboring gene predicted gene, 53506 Neighboring gene SET nuclear oncogene pseudogene Neighboring gene STARR-seq mESC enhancer starr_24769 Neighboring gene STARR-seq mESC enhancer starr_24770 Neighboring gene STARR-seq mESC enhancer starr_24771 Neighboring gene STARR-seq mESC enhancer starr_24772 Neighboring gene STARR-seq mESC enhancer starr_24773 Neighboring gene STARR-seq mESC enhancer starr_24774 Neighboring gene STARR-seq mESC enhancer starr_24775 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide pseudogene Neighboring gene RIKEN cDNA 1700063H06 gene Neighboring gene predicted gene, 23748 Neighboring gene predicted gene, 35548

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bi-allelic missense variants in MEI4 cause preimplantation embryonic arrest and female infertility. Pan Z, et al. Hum Genet, 2024 Oct. PMID 38252283
  2. Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation. Laroussi H, et al. EMBO J, 2023 Aug 15. PMID 37431931, Free PMC Article
  3. Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes. Papanikos F, et al. Mol Cell, 2019 Jun 6. PMID 31000436
  4. Ensuring meiotic DNA break formation in the mouse pseudoautosomal region. Acquaviva L, et al. Nature, 2020 Jun. PMID 32461690, Free PMC Article
  5. Principles of chromosome organization for meiotic recombination. Biot M, et al. Mol Cell, 2024 May 16. PMID 38657614

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bi-allelic missense variants in MEI4 cause preimplantation embryonic arrest and female infertility.
    Title: Bi-allelic missense variants in MEI4 cause preimplantation embryonic arrest and female infertility.
  2. Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation.
    Title: Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation.
  3. the association of MEI4 to chromosome axes is required for DNA double-strand break formation.
    Title: MEI4 – a central player in the regulation of meiotic DNA double-strand break formation in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic DNA double-strand break formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic DNA double-strand break formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lateral element IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lateral element IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
meiosis-specific protein MEI4
Names
UPF0623 protein
meiosis-specific, MEI4 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357477.1 → NP_001344406.1  meiosis-specific protein MEI4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC140070, AC163294, AK082395
    Consensus CDS
    CCDS90635.1
    Related
    ENSMUSP00000140647.2, ENSMUST00000189832.7
    Conserved Domains (1) summary
    pfam13971
    Location:2 → 300
    Mei4; Meiosis-specific protein Mei4

  2. NM_001357479.1 → NP_001344408.1  meiosis-specific protein MEI4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC122931, AC132430, AC163294
    Consensus CDS
    CCDS90636.1
    UniProtKB/TrEMBL
    A0A087WP18, Q3TM14
    Related
    ENSMUSP00000139589.2, ENSMUST00000189391.2
    Conserved Domains (1) summary
    pfam13971
    Location:4 → 278
    Mei4; Meiosis-specific protein Mei4

  3. NM_175213.4 → NP_780422.1  meiosis-specific protein MEI4 isoform 1

    See identical proteins and their annotated locations for NP_780422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC122931, AC163294, AK043929
    Consensus CDS
    CCDS23371.1
    UniProtKB/Swiss-Prot
    Q4V9Z7, Q8BRM6, Q8C4E8
    UniProtKB/TrEMBL
    Q3TM14
    Related
    ENSMUSP00000061341.3, ENSMUST00000057067.10
    Conserved Domains (1) summary
    pfam13971
    Location:1 → 377
    Mei4; Meiosis-specific protein Mei4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    81745723..82088060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BRM6.1 GenPept UniProtKB/Swiss-Prot:Q8BRM6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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