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Dusp18 dual specificity phosphatase 18 [ Mus musculus (house mouse) ]

Gene ID: 75219, updated on 2-Nov-2024

Summary

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Official Symbol
Dusp18provided by MGI
Official Full Name
dual specificity phosphatase 18provided by MGI
Primary source
MGI:MGI:1922469
See related
Ensembl:ENSMUSG00000047205 AllianceGenome:MGI:1922469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DSP18; DUSP20; LMWDSP20; 4930527G07Rik
Summary
Predicted to enable protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in peptidyl-threonine dephosphorylation and peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within protein targeting to membrane; protein targeting to mitochondrion; and response to antibiotic. Predicted to be located in mitochondrial inner membrane; mitochondrial intermembrane space; and nucleoplasm. Predicted to be extrinsic component of mitochondrial inner membrane. Predicted to be active in cytoplasm. Is expressed in central nervous system; dorsal root ganglion; olfactory epithelium; and retina. Orthologous to human DUSP18 (dual specificity phosphatase 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in heart adult (RPKM 4.6), testis adult (RPKM 2.8) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Dusp18 in Genome Data Viewer
Location:
11 A1; 11 2.74 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3844940..3851299)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3894935..3901299)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_28364 Neighboring gene predicted gene, 51880 Neighboring gene STARR-seq mESC enhancer starr_28365 Neighboring gene STARR-positive B cell enhancer ABC_E8382 Neighboring gene RIKEN cDNA 4921536K21 gene Neighboring gene nucleolar protein 8 pseudogene Neighboring gene solute carrier family 35, member E4 Neighboring gene transcobalamin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer. Zhou X, et al. Nat Commun, 2024 Jul 12. PMID 38992029, Free PMC Article
  2. A novel phosphatase family, structurally related to dual-specificity phosphatases, that displays unique amino acid sequence and substrate specificity. Romá-Mateo C, et al. J Mol Biol, 2007 Dec 7. PMID 17976645
  3. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. Rardin MJ, et al. J Biol Chem, 2008 May 30. PMID 18385140, Free PMC Article
  4. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article
  5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer.
    Title: Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer.
  2. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane
    Title: Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine/serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-threonine dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-threonine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-tyrosine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein localization to organelle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within protein targeting to membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within protein targeting to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within response to antibiotic ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in extrinsic component of mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 18
Names
low molecular weight dual specificity phosphatase 20
NP_776106.1
XP_006514936.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173745.5 → NP_776106.1  dual specificity protein phosphatase 18

    See identical proteins and their annotated locations for NP_776106.1

    Status: VALIDATED

    Source sequence(s)
    AK052827, AK081916, BB512576, CN536942
    Consensus CDS
    CCDS24369.1
    UniProtKB/Swiss-Prot
    Q8VE01
    Related
    ENSMUSP00000057346.5, ENSMUST00000055931.5
    Conserved Domains (1) summary
    cl28904
    Location:19 → 176
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3844940..3851299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514873.4 → XP_006514936.1  dual specificity protein phosphatase 18 isoform X1

    See identical proteins and their annotated locations for XP_006514936.1

    UniProtKB/Swiss-Prot
    Q8VE01
    Conserved Domains (1) summary
    cl28904
    Location:19 → 176
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE01.1 GenPept UniProtKB/Swiss-Prot:Q8VE01

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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