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YES1 YES proto-oncogene 1, Src family tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 7525, updated on 3-Nov-2024

Summary

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Official Symbol
YES1provided by HGNC
Official Full Name
YES proto-oncogene 1, Src family tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:12841
See related
Ensembl:ENSG00000176105 MIM:164880; AllianceGenome:HGNC:12841
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Yes; c-yes; HsT441; P61-YES
Summary
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 22.4), fat (RPKM 16.6) and 25 other tissues See more
Orthologs
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Genomic context

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See YES1 in Genome Data Viewer
Location:
18p11.32
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (721588..812753, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (875925..969846, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (721588..812243, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene clusterin like 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:657377-657878 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:657879-658378 Neighboring gene TYMS opposite strand RNA Neighboring gene enolase superfamily member 1 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr18:686134-686722 Neighboring gene thymidylate synthetase Neighboring gene ReSE screen-validated silencer GRCh37_chr18:697612-697744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:712826-713405 Neighboring gene Sharpr-MPRA regulatory region 6782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13022 Neighboring gene RNA, U1 small nuclear 109, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9243 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9244 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:812361-812903 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:812904-813445 Neighboring gene NANOG hESC enhancer GRCh37_chr18:830325-830891 Neighboring gene bolA family member 2 pseudogene 1 Neighboring gene proteasome 26S subunit, non-ATPase 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma. Wan X, et al. Neoplasia, 2015 Apr. PMID 25925378, Free PMC Article
  2. Differential expression of Yes-associated protein is correlated with expression of cell cycle markers and pathologic TNM staging in non-small-cell lung carcinoma. Kim JM, et al. Hum Pathol, 2011 Mar. PMID 21190720
  3. Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3. Hamamura K, et al. J Biol Chem, 2011 May 27. PMID 21454696, Free PMC Article
  4. Overexpression of YES1 is associated with favorable prognosis and increased platinum-sensitivity in patients with epithelial ovarian cancer. Zhou Y, et al. Histol Histopathol, 2020 Jul. PMID 31970720
  5. Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells. Barraclough J, et al. Neoplasia, 2007 Sep. PMID 17898870, Free PMC Article

See all (232) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p-HMGB1 axis.
    Title: Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p-HMGB1 axis.
  2. YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1.
    Title: YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1.
  3. YES1 Is a Druggable Oncogenic Target in SCLC.
    Title: YES1 Is a Druggable Oncogenic Target in SCLC.
  4. Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma.
    Title: Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma.
  5. EphA2-YES1-ANXA2 pathway promotes gastric cancer progression and metastasis.
    Title: EphA2-YES1-ANXA2 pathway promotes gastric cancer progression and metastasis.
  6. Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation.
    Title: Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation.
  7. Overexpression of YES1 is associated with favorable prognosis and increased platinum-sensitivity in patients with epithelial ovarian cancer.
    Title: Overexpression of YES1 is associated with favorable prognosis and increased platinum-sensitivity in patients with epithelial ovarian cancer.
  8. MiR-133 Targets YES1 and Inhibits the Growth of Triple-Negative Breast Cancer Cells.
    Title: MiR-133 Targets YES1 and Inhibits the Growth of Triple-Negative Breast Cancer Cells.
  9. Genome-Wide Analysis Identifies Two Susceptibility Loci for Positive Thyroid Peroxidase and Thyroglobulin Antibodies.
    Title: Genome-Wide Analysis Identifies Two Susceptibility Loci for Positive Thyroid Peroxidase and Thyroglobulin Antibodies.
  10. YES1 is essential for NSCLC carcinogenesis. YES1 overexpression induced metastatic spread in preclinical in vivo models. YES1 genetic depletion by CRISPR/Cas9 technology significantly reduced tumor growth and metastasis.
    Title: YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 (YES1) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
  
involved_in T cell costimulation TAS
Traceable Author Statement
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to platelet-derived growth factor stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leukocyte migration TAS
Traceable Author Statement
more info
  
involved_in negative regulation of inflammatory response to antigenic stimulus TAS
Traceable Author Statement
more info
  
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in protein modification process TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of D-glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of vascular permeability TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin filament IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase Yes
Names
YES1 proto-oncogene, Src family tyrosine kinase
Yamaguchi sarcoma oncogene
cellular yes-1 protein
proto-oncogene c-Yes
proto-oncogene tyrosine-protein kinase YES
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
NP_005424.1
XP_005258196.1
XP_016881449.1
XP_024307011.1
XP_024307012.1
XP_024307013.1
XP_024307014.1
XP_024307015.1
XP_047293726.1
XP_047293727.1
XP_054175018.1
XP_054175019.1
XP_054175020.1
XP_054175021.1
XP_054175022.1
XP_054175023.1
XP_054175024.1
XP_054175025.1
XP_054175026.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005433.4 → NP_005424.1  tyrosine-protein kinase Yes

    See identical proteins and their annotated locations for NP_005424.1

    Status: REVIEWED

    Source sequence(s)
    AP000894, AP001020, AP001178
    Consensus CDS
    CCDS11824.1
    UniProtKB/Swiss-Prot
    A6NLB3, D3DUH1, P07947
    UniProtKB/TrEMBL
    B2RA70
    Related
    ENSP00000324740.4, ENST00000314574.5
    Conserved Domains (3) summary
    cd09933
    Location:154 → 253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94 → 151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:264 → 542
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    721588..812753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437770.1 → XP_047293726.1  tyrosine-protein kinase Yes isoform X2

  2. XM_024451244.2 → XP_024307012.1  tyrosine-protein kinase Yes isoform X1

    UniProtKB/Swiss-Prot
    A6NLB3, D3DUH1, P07947
    UniProtKB/TrEMBL
    B2RA70
    Conserved Domains (3) summary
    cd09933
    Location:154 → 253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94 → 151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:264 → 542
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

  3. XM_047437771.1 → XP_047293727.1  tyrosine-protein kinase Yes isoform X2

  4. XM_024451246.2 → XP_024307014.1  tyrosine-protein kinase Yes isoform X1

    UniProtKB/Swiss-Prot
    A6NLB3, D3DUH1, P07947
    UniProtKB/TrEMBL
    B2RA70
    Conserved Domains (3) summary
    cd09933
    Location:154 → 253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94 → 151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:264 → 542
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

  5. XM_024451247.2 → XP_024307015.1  tyrosine-protein kinase Yes isoform X2

    UniProtKB/TrEMBL
    B2RA70
    Conserved Domains (3) summary
    cd09933
    Location:154 → 253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94 → 151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cl21453
    Location:264 → 498
    PKc_like; Protein Kinases, catalytic domain

  6. XM_024451243.2 → XP_024307011.1  tyrosine-protein kinase Yes isoform X1

    UniProtKB/Swiss-Prot
    A6NLB3, D3DUH1, P07947
    UniProtKB/TrEMBL
    B2RA70
    Related
    ENSP00000462468.1, ENST00000584307.5
    Conserved Domains (3) summary
    cd09933
    Location:154 → 253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94 → 151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:264 → 542
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

  7. XM_005258139.5 → XP_005258196.1  tyrosine-protein kinase Yes isoform X2

    See identical proteins and their annotated locations for XP_005258196.1

    UniProtKB/TrEMBL
    B2RA70
    Conserved Domains (3) summary
    cd09933
    Location:154 → 253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94 → 151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cl21453
    Location:264 → 498
    PKc_like; Protein Kinases, catalytic domain

  8. XM_017025960.3 → XP_016881449.1  tyrosine-protein kinase Yes isoform X1

    UniProtKB/Swiss-Prot
    A6NLB3, D3DUH1, P07947
    UniProtKB/TrEMBL
    B2RA70
    Conserved Domains (3) summary
    cd09933
    Location:154 → 253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94 → 151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:264 → 542
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

  9. XM_024451245.2 → XP_024307013.1  tyrosine-protein kinase Yes isoform X1

    UniProtKB/Swiss-Prot
    A6NLB3, D3DUH1, P07947
    UniProtKB/TrEMBL
    B2RA70
    Related
    ENSP00000464380.1, ENST00000577961.5
    Conserved Domains (3) summary
    cd09933
    Location:154 → 253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94 → 151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:264 → 542
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    875925..969846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319050.1 → XP_054175025.1  tyrosine-protein kinase Yes isoform X2

  2. XM_054319044.1 → XP_054175019.1  tyrosine-protein kinase Yes isoform X1

    UniProtKB/Swiss-Prot
    A6NLB3, D3DUH1, P07947

  3. XM_054319045.1 → XP_054175020.1  tyrosine-protein kinase Yes isoform X1

    UniProtKB/Swiss-Prot
    A6NLB3, D3DUH1, P07947

  4. XM_054319049.1 → XP_054175024.1  tyrosine-protein kinase Yes isoform X2

  5. XM_054319043.1 → XP_054175018.1  tyrosine-protein kinase Yes isoform X1

    UniProtKB/Swiss-Prot
    A6NLB3, D3DUH1, P07947

  6. XM_054319051.1 → XP_054175026.1  tyrosine-protein kinase Yes isoform X2

  7. XM_054319048.1 → XP_054175023.1  tyrosine-protein kinase Yes isoform X2

  8. XM_054319046.1 → XP_054175021.1  tyrosine-protein kinase Yes isoform X1

    UniProtKB/Swiss-Prot
    A6NLB3, D3DUH1, P07947

  9. XM_054319047.1 → XP_054175022.1  tyrosine-protein kinase Yes isoform X1

    UniProtKB/Swiss-Prot
    A6NLB3, D3DUH1, P07947
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07947.3 GenPept UniProtKB/Swiss-Prot:P07947

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