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Etnk1 ethanolamine kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 75320, updated on 2-Nov-2024

Summary

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Official Symbol
Etnk1provided by MGI
Official Full Name
ethanolamine kinase 1provided by MGI
Primary source
MGI:MGI:1922570
See related
Ensembl:ENSMUSG00000030275 AllianceGenome:MGI:1922570
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EKI1; D6Ertd3e; 1110061E11Rik; 4930555L11Rik
Summary
Predicted to enable ethanolamine kinase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including early embryo; endocrine gland; ganglia; male reproductive gland or organ; and retina. Orthologous to human ETNK1 (ethanolamine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 42.2), CNS E18 (RPKM 41.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Etnk1 in Genome Data Viewer
Location:
6 G3; 6 75.41 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (143112592..143154272)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (143166866..143208546)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene C2 calcium-dependent domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E2807 Neighboring gene STARR-seq mESC enhancer starr_17724 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:143063726-143063909 Neighboring gene predicted gene, 31108 Neighboring gene STARR-seq mESC enhancer starr_17725 Neighboring gene STARR-positive B cell enhancer ABC_E2808 Neighboring gene STARR-seq mESC enhancer starr_17731 Neighboring gene predicted gene, 38921 Neighboring gene STARR-positive B cell enhancer ABC_E2215 Neighboring gene STARR-positive B cell enhancer ABC_E2216 Neighboring gene RIKEN cDNA 1700126G02 gene Neighboring gene predicted gene, 57769 Neighboring gene RIKEN cDNA 4930407I02 gene Neighboring gene predicted gene, 52926

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Eki2 is upregulated specifically in the testis during mouse sex determination. Hurley TM, et al. Gene Expr Patterns, 2004 Mar. PMID 15161093
  2. IDH1 regulates phospholipid metabolism in developing astrocytes. Bogdanovic E, et al. Neurosci Lett, 2014 Oct 17. PMID 25218477, Free PMC Article
  3. A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice. Li Z, et al. PLoS One, 2010 Aug 17. PMID 20808911, Free PMC Article
  4. Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis. Yu X, et al. Arthritis Res Ther, 2007. PMID 17244351, Free PMC Article
  5. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of Etnk1 in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase).
    Title: A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ethanolamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ethanolamine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ethanolamine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylethanolamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylethanolamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ethanolamine kinase 1
Names
EKI 1
NP_083526.2
XP_006507074.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029250.2 → NP_083526.2  ethanolamine kinase 1

    See identical proteins and their annotated locations for NP_083526.2

    Status: VALIDATED

    Source sequence(s)
    AK044502, AK049691, BQ175711
    Consensus CDS
    CCDS57468.1
    UniProtKB/Swiss-Prot
    F6Y9V2, Q8BXQ0, Q9D4V0
    UniProtKB/TrEMBL
    Q8BWV4
    Related
    ENSMUSP00000032413.5, ENSMUST00000032413.7
    Conserved Domains (2) summary
    PLN02236
    Location:26 → 356
    PLN02236; choline kinase
    cd05157
    Location:49 → 351
    ETNK_euk; Euykaryotic Ethanolamine kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    143112592..143154272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507011.5 → XP_006507074.1  ethanolamine kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A0N4SV10
    Conserved Domains (1) summary
    cd05157
    Location:49 → 261
    ETNK_euk; Euykaryotic Ethanolamine kinase

RNA

  1. XR_004933629.1 RNA Sequence

  2. XR_004933630.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D4V0.2 GenPept UniProtKB/Swiss-Prot:Q9D4V0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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