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Mphosph8 M-phase phosphoprotein 8 [ Mus musculus (house mouse) ]

Gene ID: 75339, updated on 14-Nov-2024

Summary

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Official Symbol
Mphosph8provided by MGI
Official Full Name
M-phase phosphoprotein 8provided by MGI
Primary source
MGI:MGI:1922589
See related
Ensembl:ENSMUSG00000079184 AllianceGenome:MGI:1922589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500035L22Rik; 4930548G07Rik
Summary
Predicted to enable chromatin binding activity and methylated histone binding activity. Predicted to be involved in negative regulation of gene expression via chromosomal CpG island methylation; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and positive regulation of DNA methylation-dependent heterochromatin formation. Predicted to be located in several cellular components, including cytosol; heterochromatin; and nuclear lumen. Predicted to be part of nucleosome. Predicted to be active in cytoplasm and nucleus. Is expressed in inner cell mass and trophectoderm. Orthologous to human MPHOSPH8 (M-phase phosphoprotein 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 15.4), CNS E14 (RPKM 8.2) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Mphosph8 in Genome Data Viewer
Location:
14 C3; 14 28.37 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56905692..56934887)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56668235..56697430)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) polymerase family, member 4 Neighboring gene predicted gene 16573 Neighboring gene STARR-positive B cell enhancer ABC_E755 Neighboring gene basic transcription factor 3, pseudogene 18 Neighboring gene predicted gene, 16973 Neighboring gene paraspeckle protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E9897 Neighboring gene predicted gene 4479

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MPP8 Governs the Activity of the LIF/STAT3 Pathway and Plays a Crucial Role in the Differentiation of Mouse Embryonic Stem Cells. Zhang H, et al. Cells, 2023 Aug 8. PMID 37626833, Free PMC Article
  2. Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia. Gu Z, et al. Nat Genet, 2021 May. PMID 33833453, Free PMC Article
  3. The HUSH complex controls brain architecture and protocadherin fidelity. Hagelkruys A, et al. Sci Adv, 2022 Nov 4. PMID 36332029, Free PMC Article
  4. Dual role of Fam208a during zygotic cleavage and early embryonic development. Gresakova V, et al. Exp Cell Res, 2021 Sep 15. PMID 34216590
  5. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Maier VK, et al. Mol Cell Proteomics, 2015 Jun. PMID 25680957, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MPP8 Governs the Activity of the LIF/STAT3 Pathway and Plays a Crucial Role in the Differentiation of Mouse Embryonic Stem Cells.
    Title: MPP8 Governs the Activity of the LIF/STAT3 Pathway and Plays a Crucial Role in the Differentiation of Mouse Embryonic Stem Cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone reader activity IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in constitutive heterochromatin formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of gene expression via chromosomal CpG island methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression via chromosomal CpG island methylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
Inferred from Sequence Orthology
more info
  
involved_in transposable element silencing by heterochromatin formation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in heterochromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
M-phase phosphoprotein 8
NP_001347001.1
NP_076262.2
XP_036014782.1
XP_036014783.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360072.1 → NP_001347001.1  M-phase phosphoprotein 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154731, AK158773, BU757804, BY111264
    UniProtKB/TrEMBL
    Q9JJB4
    Conserved Domains (4) summary
    smart00298
    Location:58 → 109
    CHROMO; Chromatin organization modifier domain
    cd00204
    Location:605 → 729
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:613 → 641
    ANK; ANK repeat [structural motif]
    cl26511
    Location:97 → 482
    Neuromodulin_N; Gap junction protein N-terminal region

  2. NM_023773.2 → NP_076262.2  M-phase phosphoprotein 8 isoform 1

    See identical proteins and their annotated locations for NP_076262.2

    Status: VALIDATED

    Source sequence(s)
    AK158773, BU757804, BY111264
    Consensus CDS
    CCDS49504.1
    UniProtKB/Swiss-Prot
    A6H600, Q3TWY7, Q3TYA6
    UniProtKB/TrEMBL
    Q9JJB4
    Related
    ENSMUSP00000112170.2, ENSMUST00000116468.2
    Conserved Domains (4) summary
    smart00298
    Location:58 → 109
    CHROMO; Chromatin organization modifier domain
    cd00204
    Location:593 → 717
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:604 → 693
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:601 → 629
    ANK; ANK repeat [structural motif]

RNA

  1. NR_153396.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC145164, BU757804, BY111264

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    56905692..56934887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158889.1 → XP_036014782.1  M-phase phosphoprotein 8 isoform X1

    Conserved Domains (2) summary
    cd18633
    Location:58 → 108
    CD_MMP8; chromodomain of M-phase phosphoprotein 8
    NF037998
    Location:173 → 252
    RND_1; protein translocase

  2. XM_036158890.1 → XP_036014783.1  M-phase phosphoprotein 8 isoform X2

    UniProtKB/TrEMBL
    Q3ULG7
    Conserved Domains (2) summary
    PTZ00121
    Location:97 → 438
    PTZ00121; MAEBL; Provisional
    cd18633
    Location:58 → 108
    CD_MMP8; chromodomain of M-phase phosphoprotein 8

RNA

  1. XR_383217.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TYA6.1 GenPept UniProtKB/Swiss-Prot:Q3TYA6

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