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Arhgap12 Rho GTPase activating protein 12 [ Mus musculus (house mouse) ]

Gene ID: 75415, updated on 28-Oct-2024

Summary

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Official Symbol
Arhgap12provided by MGI
Official Full Name
Rho GTPase activating protein 12provided by MGI
Primary source
MGI:MGI:1922665
See related
Ensembl:ENSMUSG00000041225 AllianceGenome:MGI:1922665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810011M08Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including negative regulation of small GTPase mediated signal transduction; phagocytosis, engulfment; and small GTPase-mediated signal transduction. Predicted to be located in phagocytic cup. Predicted to be active in cytoplasm and plasma membrane. Is expressed in bladder; gut; nervous system; sensory organ; and skeleton. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in bladder adult (RPKM 10.7), CNS E14 (RPKM 8.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Arhgap12 in Genome Data Viewer
Location:
18 A1; 18 4.46 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (6024448..6136102, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (6024448..6136098, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34804 Neighboring gene STARR-positive B cell enhancer mm9_chr18:5989955-5990255 Neighboring gene predicted gene, 41663 Neighboring gene predicted gene, 41662 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_43701 Neighboring gene predicted gene, 18278 Neighboring gene STARR-positive B cell enhancer ABC_E1514 Neighboring gene STARR-seq mESC enhancer starr_43702 Neighboring gene STARR-seq mESC enhancer starr_43703 Neighboring gene kinesin family member 5B Neighboring gene predicted gene, 41664 Neighboring gene STARR-seq mESC enhancer starr_43704 Neighboring gene STARR-seq mESC enhancer starr_43705 Neighboring gene STARR-seq mESC enhancer starr_43706 Neighboring gene STARR-seq mESC enhancer starr_43709 Neighboring gene STARR-seq mESC enhancer starr_43711 Neighboring gene STARR-seq mESC enhancer starr_43712 Neighboring gene ribosomal protein L27, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Circular RNA Arhgap12 modulates doxorubicin-induced cardiotoxicity by sponging miR-135a-5p. Wang X, et al. Life Sci, 2021 Jan 15. PMID 33245966
  2. Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning. Matsuda M, et al. Exp Cell Res, 2008 Mar 10. PMID 18241859
  3. Next-generation sequencing of small RNAs from inner ear sensory epithelium identifies microRNAs and defines regulatory pathways. Rudnicki A, et al. BMC Genomics, 2014 Jun 18. PMID 24942165, Free PMC Article
  4. Met-driven invasive growth involves transcriptional regulation of Arhgap12. Gentile A, et al. Oncogene, 2008 Sep 18. PMID 18504429
  5. Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development. Cesari E, et al. Nucleic Acids Res, 2024 May 8. PMID 38324473, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA Arhgap12 modulates doxorubicin-induced cardiotoxicity by sponging miR-135a-5p.
    Title: Circular RNA Arhgap12 modulates doxorubicin-induced cardiotoxicity by sponging miR-135a-5p.
  2. ARHGAP12 inactivates RAC1, thereby impairing cell motility, invasion and adhesion to the extracellular matrix. The gene is transcriptionally suppressed by Hepatocyte Growth Factor in human and murine cell lines.
    Title: Met-driven invasive growth involves transcriptional regulation of Arhgap12.
  3. Immunofluorescence staining and confocal laser-scanning microscopy demonstrated that Arhgap12 localizes at epithelial cell-cell adherent junctions in various mouse tissues.
    Title: Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in morphogenesis of an epithelial sheet ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of small GTPase mediated signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
  
involved_in phagocytosis, engulfment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic cup ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic cup ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 12
Names
rho-type GTPase-activating protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039692.1 → NP_001034781.1  rho GTPase-activating protein 12 isoform 1

    See identical proteins and their annotated locations for NP_001034781.1

    Status: VALIDATED

    Source sequence(s)
    AC168050, AK031648, AK077063, BC037608
    Consensus CDS
    CCDS37723.1
    UniProtKB/Swiss-Prot
    Q8BVP8, Q8C0D4
    Related
    ENSMUSP00000138585.2, ENSMUST00000182559.8
    Conserved Domains (6) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:266 → 296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:646 → 831
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:457 → 568
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:467 → 566
    PH; PH domain
    pfam16618
    Location:69 → 264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  2. NM_029277.2 → NP_083553.2  rho GTPase-activating protein 12 isoform 2

    See identical proteins and their annotated locations for NP_083553.2

    Status: VALIDATED

    Source sequence(s)
    AC168050, AK077063, BC037608
    Consensus CDS
    CCDS37722.1
    UniProtKB/TrEMBL
    B2RUJ8
    Related
    ENSMUSP00000076376.6, ENSMUST00000077128.13
    Conserved Domains (6) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:266 → 296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:621 → 806
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:432 → 543
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:442 → 541
    PH; PH domain
    pfam16618
    Location:69 → 264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    6024448..6136102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250623.2 → XP_030106483.1  rho GTPase-activating protein 12 isoform X8

    Conserved Domains (4) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd04403
    Location:487 → 672
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:298 → 409
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69 → 226
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  2. XM_036161302.1 → XP_036017195.1  rho GTPase-activating protein 12 isoform X7

    Conserved Domains (4) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd04403
    Location:512 → 697
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:323 → 434
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69 → 226
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  3. XM_017318001.2 → XP_017173490.1  rho GTPase-activating protein 12 isoform X6

    Conserved Domains (4) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd04403
    Location:517 → 702
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:328 → 439
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69 → 226
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  4. XM_006526316.2 → XP_006526379.1  rho GTPase-activating protein 12 isoform X5

    UniProtKB/TrEMBL
    S4R203
    Related
    ENSMUSP00000138444.2, ENSMUST00000182383.8
    Conserved Domains (6) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    COG5104
    Location:257 → 362
    PRP40; Splicing factor [RNA processing and modification]
    cd00201
    Location:266 → 296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:574 → 759
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:385 → 496
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69 → 264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  5. XM_036161301.1 → XP_036017194.1  rho GTPase-activating protein 12 isoform X4

    UniProtKB/TrEMBL
    S4R248
    Related
    ENSMUSP00000138496.2, ENSMUST00000182066.8
    Conserved Domains (6) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    COG5104
    Location:257 → 362
    PRP40; Splicing factor [RNA processing and modification]
    cd00201
    Location:266 → 296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:599 → 784
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:410 → 521
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69 → 264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  6. XM_006526315.2 → XP_006526378.1  rho GTPase-activating protein 12 isoform X3

    UniProtKB/TrEMBL
    A0A0A0MQ95
    Related
    ENSMUSP00000054209.8, ENSMUST00000062584.14
    Conserved Domains (6) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    COG5104
    Location:257 → 362
    PRP40; Splicing factor [RNA processing and modification]
    cd00201
    Location:266 → 296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:604 → 789
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:415 → 526
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69 → 264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  7. XM_011247018.2 → XP_011245320.1  rho GTPase-activating protein 12 isoform X2

    Conserved Domains (6) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    COG5104
    Location:257 → 409
    PRP40; Splicing factor [RNA processing and modification]
    cd00201
    Location:266 → 296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:626 → 811
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:437 → 548
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69 → 264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  8. XM_006526314.2 → XP_006526377.1  rho GTPase-activating protein 12 isoform X1

    UniProtKB/TrEMBL
    S4R221
    Related
    ENSMUSP00000138464.2, ENSMUST00000182213.8
    Conserved Domains (6) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    COG5104
    Location:257 → 409
    PRP40; Splicing factor [RNA processing and modification]
    cd00201
    Location:266 → 296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:651 → 836
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:462 → 573
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69 → 264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0D4.2 GenPept UniProtKB/Swiss-Prot:Q8C0D4

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