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ZFX zinc finger protein X-linked [ Homo sapiens (human) ]

Gene ID: 7543, updated on 4-Apr-2024

Summary

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Official Symbol
ZFXprovided by HGNC
Official Full Name
zinc finger protein X-linkedprovided by HGNC
Primary source
HGNC:HGNC:12869
See related
Ensembl:ENSG00000005889 MIM:314980; AllianceGenome:HGNC:12869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRXS37; ZNF926
Summary
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in endometrium (RPKM 5.2), thyroid (RPKM 4.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
Xp22.11
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (24148982..24216255)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (23733193..23800453)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (24167099..24234372)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905261 Neighboring gene uncharacterized LOC124905260 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:24111108-24111608 Neighboring gene small nucleolar RNA SNORA68 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29499 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:24167489-24168302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29500 Neighboring gene ZFX antisense RNA 1 Neighboring gene CRISPRi-validated cis-regulatory element chrX.477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29504 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:24328768-24329520 Neighboring gene SUPT20H like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:24382719-24383459 Neighboring gene SUPT20H like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Homoharringtonine enhances the effect of imatinib on chronic myelogenous leukemia cells by downregulating ZFX. Wu J, et al. Mol Med Rep, 2019 Oct. PMID 31432109, Free PMC Article
  2. ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer. Cai L, et al. Mol Cell, 2018 Oct 18. PMID 30270106, Free PMC Article
  3. ZFX Promotes Proliferation and Metastasis of Pancreatic Cancer Cells via the MAPK Pathway. Song X, et al. Cell Physiol Biochem, 2018. PMID 30007968
  4. Differential Expression Profile of ZFX Variants Discriminates Breast Cancer Subtypes. Pourkeramati F, et al. Iran Biomed J, 2019 Jan. PMID 29753316, Free PMC Article
  5. Zinc finger protein X-linked promotes expansion of EpCAM(+) cancer stem-like cells in hepatocellular carcinoma. Wang C, et al. Mol Oncol, 2017 May. PMID 28156061, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Variants in ZFX are associated with an X-linked neurodevelopmental disorder with recurrent facial gestalt.
    Title: Variants in ZFX are associated with an X-linked neurodevelopmental disorder with recurrent facial gestalt.
  2. Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis.
    Title: Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis.
  3. Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer progression via PI3K/AKT pathway.
    Title: Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer progression via PI3K/AKT pathway.
  4. Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.
    Title: Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.
  5. Our data indicate that CCAT1 promotes triple-negative breast cancer progression by targeting the miR-218/ZFX axis
    Title: CCAT1 promotes triple-negative breast cancer progression by suppressing miR-218/ZFX signaling.
  6. LncRNA SNHG20 contributes to cell proliferation and invasion by upregulating ZFX expression sponging miR-495-3p in gastric cancer
    Title: LncRNA SNHG20 contributes to cell proliferation and invasion by upregulating ZFX expression sponging miR-495-3p in gastric cancer.
  7. Homoharringtonine may enhance the effect of imatinib on chronic myelogenous leukemia cells by downregulating ZFX.
    Title: Homoharringtonine enhances the effect of imatinib on chronic myelogenous leukemia cells by downregulating ZFX.
  8. AR-V7 has both ARE/FOXA1 canonical and ZFX-directed non-canonical regulatory functions in the evolution of anti-androgen therapeutic resistance.
    Title: ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer.
  9. ZFX-spliced transcripts could be considered as novel tumor markers with a probable value in diagnosis, prognosis, and therapy of breast cancer.
    Title: Differential Expression Profile of ZFX Variants Discriminates Breast Cancer Subtypes.
  10. MiR-493 functioned as tumor suppressor in HCC cells by regulating ZFX expression. Thus, miR-493 may provide potential value for HCC treatment.
    Title: MicroRNA-493 suppresses cell proliferation and invasion by targeting ZFX in human hepatocellular carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC 37
MedGen: CN377268 OMIM: 301118 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin insulator sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fertilization IEA
Inferred from Electronic Annotation
more info
  
involved_in homeostasis of number of cells IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
  
involved_in oocyte development IEA
Inferred from Electronic Annotation
more info
  
involved_in ovarian follicle development IEA
Inferred from Electronic Annotation
more info
  
involved_in parental behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
zinc finger X-chromosomal protein
Names
X-linked zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021253.2 RefSeqGene

    Range
    4993..71519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178084.2 → NP_001171555.1  zinc finger X-chromosomal protein isoform 1

    See identical proteins and their annotated locations for NP_001171555.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons in the 5' UTR, as compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AB209892, AC002404, DA995443, X59739
    Consensus CDS
    CCDS14211.1
    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8
    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (5) summary
    COG5048
    Location:543 → 805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548 → 570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70 → 410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562 → 584
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001178085.1 → NP_001171556.1  zinc finger X-chromosomal protein isoform 1

    See identical proteins and their annotated locations for NP_001171556.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional exon in the 5' UTR, as compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AB209892, AC002404, M30608, X59740
    Consensus CDS
    CCDS14211.1
    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8
    UniProtKB/TrEMBL
    B7ZKJ5
    Related
    ENSP00000368475.1, ENST00000379177.5
    Conserved Domains (5) summary
    COG5048
    Location:543 → 805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548 → 570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70 → 410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562 → 584
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001178086.2 → NP_001171557.1  zinc finger X-chromosomal protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks several exons in the 5' region, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AB209892, AC002404, X59738
    Consensus CDS
    CCDS55390.1
    UniProtKB/TrEMBL
    Q8WXB7
    Related
    ENSP00000438233.1, ENST00000539115.5
    Conserved Domains (4) summary
    COG5048
    Location:314 → 438
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:261 → 281
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:1 → 181
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    cl19880
    Location:169 → 216
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  4. NM_001178095.2 → NP_001171566.1  zinc finger X-chromosomal protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two exons in the 5' UTR and has an additional segment in the 3' CDS, as compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AB209892, AC002404
    UniProtKB/TrEMBL
    Q59EB9
    Conserved Domains (1) summary
    pfam04704
    Location:70 → 410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region

  5. NM_001330327.2 → NP_001317256.1  zinc finger X-chromosomal protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and includes an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
    Source sequence(s)
    AA873535, AB209892, AC002404, BC136309, BP311445, BP374479, DA847701
    Consensus CDS
    CCDS83461.1
    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  6. NM_003410.4 → NP_003401.2  zinc finger X-chromosomal protein isoform 1

    See identical proteins and their annotated locations for NP_003401.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variants 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC002404, AF454950, DA848249, M30608
    Consensus CDS
    CCDS14211.1
    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8
    UniProtKB/TrEMBL
    B7ZKJ5
    Related
    ENSP00000304985.5, ENST00000304543.10
    Conserved Domains (5) summary
    COG5048
    Location:543 → 805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548 → 570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70 → 410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562 → 584
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    24148982..24216255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545581.3 → XP_011543883.1  zinc finger X-chromosomal protein isoform X3

    See identical proteins and their annotated locations for XP_011543883.1

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8
    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (5) summary
    COG5048
    Location:543 → 805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548 → 570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70 → 410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562 → 584
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047442439.1 → XP_047298395.1  zinc finger X-chromosomal protein isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  3. XM_047442450.1 → XP_047298406.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  4. XM_047442445.1 → XP_047298401.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  5. XM_047442440.1 → XP_047298396.1  zinc finger X-chromosomal protein isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  6. XM_047442451.1 → XP_047298407.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  7. XM_017029792.2 → XP_016885281.1  zinc finger X-chromosomal protein isoform X1

    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  8. XM_005274592.4 → XP_005274649.1  zinc finger X-chromosomal protein isoform X3

    See identical proteins and their annotated locations for XP_005274649.1

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8
    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (5) summary
    COG5048
    Location:543 → 805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548 → 570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70 → 410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562 → 584
    zf-H2C2_2; Zinc-finger double domain

  9. XM_017029799.2 → XP_016885288.1  zinc finger X-chromosomal protein isoform X6

    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (6) summary
    COG5048
    Location:496 → 633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443 → 463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:672 → 694
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70 → 357
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:515 → 537
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:380 → 396
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  10. XM_047442436.1 → XP_047298392.1  zinc finger X-chromosomal protein isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  11. XM_017029794.2 → XP_016885283.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8
    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (5) summary
    COG5048
    Location:543 → 805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548 → 570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70 → 410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562 → 584
    zf-H2C2_2; Zinc-finger double domain

  12. XM_047442455.1 → XP_047298411.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  13. XM_047442453.1 → XP_047298409.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  14. XM_047442441.1 → XP_047298397.1  zinc finger X-chromosomal protein isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  15. XM_047442448.1 → XP_047298404.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  16. XM_047442438.1 → XP_047298394.1  zinc finger X-chromosomal protein isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  17. XM_006724513.4 → XP_006724576.1  zinc finger X-chromosomal protein isoform X1

    See identical proteins and their annotated locations for XP_006724576.1

    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  18. XM_047442460.1 → XP_047298416.1  zinc finger X-chromosomal protein isoform X6

  19. XM_047442442.1 → XP_047298398.1  zinc finger X-chromosomal protein isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  20. XM_047442454.1 → XP_047298410.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  21. XM_017029790.2 → XP_016885279.1  zinc finger X-chromosomal protein isoform X1

    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  22. XM_005274591.5 → XP_005274648.1  zinc finger X-chromosomal protein isoform X3

    See identical proteins and their annotated locations for XP_005274648.1

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8
    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (5) summary
    COG5048
    Location:543 → 805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548 → 570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70 → 410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562 → 584
    zf-H2C2_2; Zinc-finger double domain

  23. XM_017029791.3 → XP_016885280.1  zinc finger X-chromosomal protein isoform X1

    UniProtKB/TrEMBL
    B7ZKJ5
    Related
    ENSP00000368486.4, ENST00000379188.7
    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  24. XM_047442458.1 → XP_047298414.1  zinc finger X-chromosomal protein isoform X4

  25. XM_047442461.1 → XP_047298417.1  zinc finger X-chromosomal protein isoform X6

  26. XM_017029798.3 → XP_016885287.1  zinc finger X-chromosomal protein isoform X5

    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (5) summary
    COG5048
    Location:518 → 655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:465 → 485
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:694 → 716
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:45 → 385
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:537 → 559
    zf-H2C2_2; Zinc-finger double domain

  27. XM_047442437.1 → XP_047298393.1  zinc finger X-chromosomal protein isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  28. XM_047442452.1 → XP_047298408.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  29. XM_011545579.2 → XP_011543881.1  zinc finger X-chromosomal protein isoform X3

    See identical proteins and their annotated locations for XP_011543881.1

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8
    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (5) summary
    COG5048
    Location:543 → 805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548 → 570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70 → 410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562 → 584
    zf-H2C2_2; Zinc-finger double domain

  30. XM_047442443.1 → XP_047298399.1  zinc finger X-chromosomal protein isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  31. XM_047442435.1 → XP_047298391.1  zinc finger X-chromosomal protein isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  32. XM_047442446.1 → XP_047298402.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  33. XM_017029788.2 → XP_016885277.1  zinc finger X-chromosomal protein isoform X1

    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  34. XM_047442447.1 → XP_047298403.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  35. XM_024452440.2 → XP_024308208.1  zinc finger X-chromosomal protein isoform X4

    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (5) summary
    COG5048
    Location:535 → 672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:482 → 502
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:711 → 733
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 396
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:725 → 749
    zf-H2C2_2; Zinc-finger double domain

  36. XM_047442449.1 → XP_047298405.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  37. XM_047442444.1 → XP_047298400.1  zinc finger X-chromosomal protein isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  38. XM_017029789.2 → XP_016885278.1  zinc finger X-chromosomal protein isoform X1

    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  39. XM_047442456.1 → XP_047298412.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  40. XM_047442457.1 → XP_047298413.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  41. XM_017029793.2 → XP_016885282.1  zinc finger X-chromosomal protein isoform X1

    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (6) summary
    COG5048
    Location:582 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758 → 780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109 → 449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:772 → 796
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:416 → 496
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  42. XM_017029795.2 → XP_016885284.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8
    UniProtKB/TrEMBL
    B7ZKJ5
    Related
    ENSP00000343384.3, ENST00000338565.3
    Conserved Domains (5) summary
    COG5048
    Location:543 → 805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548 → 570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70 → 410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562 → 584
    zf-H2C2_2; Zinc-finger double domain

  43. XM_047442459.1 → XP_047298415.1  zinc finger X-chromosomal protein isoform X5

  44. XM_011545583.4 → XP_011543885.3  zinc finger X-chromosomal protein isoform X2

  45. XM_005274594.6 → XP_005274651.1  zinc finger X-chromosomal protein isoform X5

    See identical proteins and their annotated locations for XP_005274651.1

    UniProtKB/TrEMBL
    B7ZKJ5
    Conserved Domains (5) summary
    COG5048
    Location:518 → 655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:465 → 485
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:694 → 716
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:45 → 385
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:537 → 559
    zf-H2C2_2; Zinc-finger double domain

  46. XM_017029801.2 → XP_016885290.1  zinc finger X-chromosomal protein isoform X7

    UniProtKB/TrEMBL
    Q8WXB7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    23733193..23800453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327741.1 → XP_054183716.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  2. XM_054327721.1 → XP_054183696.1  zinc finger X-chromosomal protein isoform X1

  3. XM_054327740.1 → XP_054183715.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  4. XM_054327732.1 → XP_054183707.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  5. XM_054327722.1 → XP_054183697.1  zinc finger X-chromosomal protein isoform X1

  6. XM_054327742.1 → XP_054183717.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  7. XM_054327726.1 → XP_054183701.1  zinc finger X-chromosomal protein isoform X1

  8. XM_054327746.1 → XP_054183721.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  9. XM_054327759.1 → XP_054183734.1  zinc finger X-chromosomal protein isoform X6

  10. XM_054327748.1 → XP_054183723.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  11. XM_054327744.1 → XP_054183719.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  12. XM_054327723.1 → XP_054183698.1  zinc finger X-chromosomal protein isoform X1

  13. XM_054327738.1 → XP_054183713.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  14. XM_054327720.1 → XP_054183695.1  zinc finger X-chromosomal protein isoform X1

  15. XM_054327717.1 → XP_054183692.1  zinc finger X-chromosomal protein isoform X1

  16. XM_054327757.1 → XP_054183732.1  zinc finger X-chromosomal protein isoform X6

  17. XM_054327724.1 → XP_054183699.1  zinc finger X-chromosomal protein isoform X1

  18. XM_054327745.1 → XP_054183720.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  19. XM_054327728.1 → XP_054183703.1  zinc finger X-chromosomal protein isoform X1

  20. XM_054327737.1 → XP_054183712.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  21. XM_054327725.1 → XP_054183700.1  zinc finger X-chromosomal protein isoform X1

  22. XM_054327753.1 → XP_054183728.1  zinc finger X-chromosomal protein isoform X4

  23. XM_054327758.1 → XP_054183733.1  zinc finger X-chromosomal protein isoform X6

  24. XM_054327754.1 → XP_054183729.1  zinc finger X-chromosomal protein isoform X5

  25. XM_054327760.1 → XP_054183735.1  zinc finger X-chromosomal protein isoform X8

  26. XM_054327718.1 → XP_054183693.1  zinc finger X-chromosomal protein isoform X1

  27. XM_054327735.1 → XP_054183710.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  28. XM_054327733.1 → XP_054183708.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  29. XM_054327719.1 → XP_054183694.1  zinc finger X-chromosomal protein isoform X1

  30. XM_054327727.1 → XP_054183702.1  zinc finger X-chromosomal protein isoform X1

  31. XM_054327752.1 → XP_054183727.1  zinc finger X-chromosomal protein isoform X4

  32. XM_054327747.1 → XP_054183722.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  33. XM_054327739.1 → XP_054183714.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  34. XM_054327734.1 → XP_054183709.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  35. XM_054327729.1 → XP_054183704.1  zinc finger X-chromosomal protein isoform X1

  36. XM_054327749.1 → XP_054183724.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  37. XM_054327743.1 → XP_054183718.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  38. XM_054327736.1 → XP_054183711.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  39. XM_054327750.1 → XP_054183725.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  40. XM_054327730.1 → XP_054183705.1  zinc finger X-chromosomal protein isoform X1

  41. XM_054327751.1 → XP_054183726.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    B9EG97, O43668, P17010, Q8WYJ8

  42. XM_054327756.1 → XP_054183731.1  zinc finger X-chromosomal protein isoform X5

  43. XM_054327731.1 → XP_054183706.1  zinc finger X-chromosomal protein isoform X2

  44. XM_054327755.1 → XP_054183730.1  zinc finger X-chromosomal protein isoform X5

  45. XM_054327761.1 → XP_054183736.1  zinc finger X-chromosomal protein isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17010.2 GenPept UniProtKB/Swiss-Prot:P17010

Gene LinkOut

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