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Cimip2c ciliary microtubule inner protein 2C [ Mus musculus (house mouse) ]

Gene ID: 75434, updated on 2-Nov-2024

Summary

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Official Symbol
Cimip2cprovided by MGI
Official Full Name
ciliary microtubule inner protein 2Cprovided by MGI
Primary source
MGI:MGI:1922684
See related
Ensembl:ENSMUSG00000029182 AllianceGenome:MGI:1922684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam166c; 1700001C02Rik; 1700047H18Rik
Summary
Involved in flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in central nervous system; femur; lung; and retina. Orthologous to human CIMIP2C (ciliary microtubule inner protein 2C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 128.9) See more
Orthologs
human all
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Genomic context

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See Cimip2c in Genome Data Viewer
Location:
5 B1; 5 16.57 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30623395..30641433)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30466029..30484089)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:30645501-30645684 Neighboring gene dynein regulatory complex subunit 1 Neighboring gene otoferlin Neighboring gene STARR-seq mESC enhancer starr_12752 Neighboring gene calcium and integrin binding family member 4 Neighboring gene predicted gene, 40272 Neighboring gene predicted gene 9899 Neighboring gene potassium channel, subfamily K, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In-cell structural insight into the stability of sperm microtubule doublet. Tai L, et al. Cell Discov, 2023 Nov 21. PMID 37989994, Free PMC Article
  2. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, et al. Cell, 2023 Jun 22. PMID 37295417
  3. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
  4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in flagellated sperm motility IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axonemal A tubule inner sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonemal microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in axonemal microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ciliary microtubule inner protein 2C
Names
UPF0573 protein C2orf70 homolog
family with sequence similarity 166, member C
protein FAM166C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417888.1 → NP_001404817.1  ciliary microtubule inner protein 2C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157761

  2. NM_001417889.1 → NP_001404818.1  ciliary microtubule inner protein 2C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157761
    UniProtKB/TrEMBL
    D3Z6F6
    Related
    ENSMUSP00000110391.2, ENSMUST00000114743.2

  3. NM_029285.2 → NP_083561.1  ciliary microtubule inner protein 2C isoform 1

    See identical proteins and their annotated locations for NP_083561.1

    Status: VALIDATED

    Source sequence(s)
    AC157761
    Consensus CDS
    CCDS19158.1
    UniProtKB/Swiss-Prot
    Q9D9M8, Q9DAS2
    Related
    ENSMUSP00000031078.4, ENSMUST00000031078.10
    Conserved Domains (1) summary
    pfam10629
    Location:19 → 83
    DUF2475; Protein of unknown function (DUF2475)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    30623395..30641433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240783.2 → XP_011239085.1  ciliary microtubule inner protein 2C isoform X1

    Conserved Domains (1) summary
    pfam10629
    Location:23 → 80
    DUF2475; Protein of unknown function (DUF2475)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAS2.1 GenPept UniProtKB/Swiss-Prot:Q9DAS2

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