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Phpt1 phosphohistidine phosphatase 1 [ Mus musculus (house mouse) ]

Gene ID: 75454, updated on 14-Nov-2024

Summary

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Official Symbol
Phpt1provided by MGI
Official Full Name
phosphohistidine phosphatase 1provided by MGI
Primary source
MGI:MGI:1922704
See related
Ensembl:ENSMUSG00000036504 AllianceGenome:MGI:1922704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PHP; Php14; 1700008C22Rik
Summary
Predicted to enable several functions, including calcium channel inhibitor activity; protein histidine phosphatase activity; and transmembrane transporter binding activity. Involved in positive regulation of cell motility. Located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Orthologous to human PHPT1 (phosphohistidine phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 79.5), CNS E14 (RPKM 73.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Phpt1 in Genome Data Viewer
Location:
2 A3; 2 17.44 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25463442..25465528, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25573430..25575514, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene endothelial differentiation-related factor 1 Neighboring gene MAM domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E1582 Neighboring gene apical junction component 1 Neighboring gene RAB, member RAS oncogene family-like 6 Neighboring gene coiled-coil domain containing 183 Neighboring gene ficolin A, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of K(ATP) Channel Trafficking in Pancreatic β-Cells by Protein Histidine Phosphorylation. Srivastava S, et al. Diabetes, 2018 May. PMID 29440278, Free PMC Article
  2. Immunohistochemical localization of phosphohistidine phosphatase PHPT1 in mouse and human tissues. Zhang XQ, et al. Ups J Med Sci, 2009. PMID 19396692, Free PMC Article
  3. 14-kDa phosphohistidine phosphatase and its role in human lung cancer cell migration and invasion. Xu A, et al. Lung Cancer, 2010 Jan. PMID 19344975
  4. Reduced viability of neuronal cells after overexpression of protein histidine phosphatase. Krieglstein J, et al. Neurochem Int, 2008 Nov. PMID 18656514
  5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein histidine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein histidine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein histidine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in lamellipodium organization IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ATP citrate synthase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of lyase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-histidine dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in leading edge of lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in leading edge of lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
14 kDa phosphohistidine phosphatase
Names
protein histidine phosphatase
NP_001405736.1
NP_083569.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418807.1 → NP_001405736.1  14 kDa phosphohistidine phosphatase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL732590

  2. NM_029293.2 → NP_083569.1  14 kDa phosphohistidine phosphatase isoform 2

    See identical proteins and their annotated locations for NP_083569.1

    Status: VALIDATED

    Source sequence(s)
    AL732590
    Consensus CDS
    CCDS15781.1
    UniProtKB/Swiss-Prot
    Q9DAK9
    Related
    ENSMUSP00000037417.7, ENSMUST00000039156.7
    Conserved Domains (1) summary
    pfam05005
    Location:8 → 113
    Ocnus; Janus/Ocnus family (Ocnus)

RNA

  1. NR_184822.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL732590

  2. NR_184823.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL732590

  3. NR_184824.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL732590

  4. NR_184825.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL732590

  5. NR_184826.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL732590

  6. NR_184827.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL732590
    Related
    ENSMUST00000147096.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25463442..25465528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAK9.1 GenPept UniProtKB/Swiss-Prot:Q9DAK9

Gene LinkOut

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