Eppin epididymal peptidase inhibitor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eppinprovided by MGI
Official Full Name: epididymal peptidase inhibitorprovided by MGI
Primary source: MGI:MGI:1922776
See related: Ensembl:ENSMUSG00000017733 AllianceGenome:MGI:1922776
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Spinlw1; 1700024E17Rik
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in defense response to bacterium; negative regulation of flagellated sperm motility; and negative regulation of peptidase activity. Located in acrosomal vesicle. Is expressed in male reproductive gland or organ. Orthologous to human EPPIN-WFDC6 (EPPIN-WFDC6 readthrough) and EPPIN (epididymal peptidase inhibitor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward genital fat pad adult (RPKM 71.8) See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 85.21 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (164430263..164435491, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (164588343..164593571, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

siRNA-mediated Eppin testicular silencing causes changes in sperm motility and calcium currents in mice.
Title: siRNA-mediated Eppin testicular silencing causes changes in sperm motility and calcium currents in mice.
Epididymal protease inhibitor (EPPIN) is a protein hub for seminal vesicle-secreted protein SVS2 binding in mouse spermatozoa.
Title: Epididymal protease inhibitor (EPPIN) is a protein hub for seminal vesicle-secreted protein SVS2 binding in mouse spermatozoa.
Microarray expression profiling of whole adrenal mRNA from ovariectomized vs. intact mice demonstrated selective upregulation of gonadal-like genes including Spinlw1 and Insl3 in GDX-induced adrenocortical tumors of the mouse.
Title: Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret.
ata indicate that androgen receptor (AR) regulation on Klk27, Rhox5, Eppin, and Cyp17 genes in adult mouse testis using chromatin immunoprecipitation (ChIP) assays.
Title: Androgen receptor binding sites identified in mouse testis.
The expression of mouse Eppin protein was detected in A1-A4 spermatogonia and the expression of human Eppin was detected in type A spermatogonia as well as in the earliest preleptotene spermatocytes.
Title: Distribution of Eppin in mouse and human testis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of calcium ion import	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of flagellated sperm motility	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eppin

Names: epididymal protease inhibitor; serine protease inhibitor-like with Kunitz and WAP domains 1; serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029325.2 → NP_083601.1 eppin precursor

See identical proteins and their annotated locations for NP_083601.1

Status: PROVISIONAL

Source sequence(s)

AK006296

Consensus CDS

CCDS17043.1

UniProtKB/Swiss-Prot

A2A5G9, Q9DA01

Related

ENSMUSP00000099389.2, ENSMUST00000103100.2

Conserved Domains (2) summary

pfam00014
Location:76 → 127

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam00095
Location:32 → 72

WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'