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Garin5a golgi associated RAB2 interactor 5A [ Mus musculus (house mouse) ]

Gene ID: 75538, updated on 2-Nov-2024

Summary

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Official Symbol
Garin5aprovided by MGI
Official Full Name
golgi associated RAB2 interactor 5Aprovided by MGI
Primary source
MGI:MGI:1922788
See related
Ensembl:ENSMUSG00000051113 AllianceGenome:MGI:1922788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GARIL5; Fam71e1; GARI-L5; 0610007G24Rik; 1700021N13Rik; 1700021P22Rik
Summary
Involved in defense response to virus; innate immune response; and positive regulation of type I interferon production. Located in Golgi apparatus. Orthologous to human GARIN5A (golgi associated RAB2 interactor 5A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 95.9) and mammary gland adult (RPKM 4.1) See more
Orthologs
human all
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Genomic context

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See Garin5a in Genome Data Viewer
Location:
7 B3; 7 28.83 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44145923..44153690)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44496499..44504266)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Josephin domain containing 2 Neighboring gene microRNA 7052 Neighboring gene RIKEN cDNA 5430431A17 gene Neighboring gene STARR-seq mESC enhancer starr_18800 Neighboring gene ER membrane protein complex subunit 10 Neighboring gene myosin binding protein C, fast-type Neighboring gene STARR-positive B cell enhancer ABC_E10437 Neighboring gene Spi-B transcription factor (Spi-1/PU.1 related) Neighboring gene polymerase (DNA directed), delta 1, catalytic subunit Neighboring gene microRNA 7053

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses. Takahama M, et al. Cell Rep, 2017 Sep 19. PMID 28930687, Free PMC Article
  2. Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads. Wang H, et al. PLoS Genet, 2024 Jun. PMID 38935810, Free PMC Article
  3. Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity. Fukuda M, et al. Mol Cell Proteomics, 2008 Jun. PMID 18256213
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the RAB2B-GARIL5 complex promotes IFN responses against DNA viruses by regulating the cGAS-STING signaling axis.
    Title: The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC161173

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Golgi-associated RAB2 interactor protein 5A
Names
Golgi associated RAB2 interactor protein 5A
Golgi-associated Rab2B interactor-like 5
Protein FAM71E1
family with sequence similarity 71, member E1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357650.2 → NP_001344579.1  Golgi-associated RAB2 interactor protein 5A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC149607
    Conserved Domains (1) summary
    pfam12480
    Location:28 → 92
    DUF3699; Protein of unknown function (DUF3699)

  2. NM_001357651.2 → NP_001344580.1  Golgi-associated RAB2 interactor protein 5A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC149607
    UniProtKB/TrEMBL
    B7XG50
    Conserved Domains (1) summary
    pfam12480
    Location:113 → 177
    DUF3699; Protein of unknown function (DUF3699)

  3. NM_001368290.1 → NP_001355219.1  Golgi-associated RAB2 interactor protein 5A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC149607
    UniProtKB/TrEMBL
    B7XG50

  4. NM_001368291.1 → NP_001355220.1  Golgi-associated RAB2 interactor protein 5A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC149607
    UniProtKB/TrEMBL
    B7XG50

  5. NM_001368292.1 → NP_001355221.1  Golgi-associated RAB2 interactor protein 5A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC149607
    Conserved Domains (1) summary
    pfam12480
    Location:2 → 61
    DUF3699; Protein of unknown function (DUF3699)

  6. NM_028169.2 → NP_082445.1  Golgi-associated RAB2 interactor protein 5A isoform 1

    See identical proteins and their annotated locations for NP_082445.1

    Status: VALIDATED

    Source sequence(s)
    AC149607
    Consensus CDS
    CCDS52232.1
    UniProtKB/Swiss-Prot
    A1L3C1, E9QKI6, Q0P5X9
    UniProtKB/TrEMBL
    B7XG50
    Related
    ENSMUSP00000103560.4, ENSMUST00000107927.5
    Conserved Domains (1) summary
    pfam12480
    Location:93 → 158
    DUF3699; Protein of unknown function (DUF3699)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44145923..44153690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243055.2 → XP_030098915.1  Golgi-associated RAB2 interactor protein 5A isoform X10

    Conserved Domains (1) summary
    pfam12480
    Location:2 → 61
    DUF3699; Protein of unknown function (DUF3699)

  2. XM_006541242.3 → XP_006541305.1  Golgi-associated RAB2 interactor protein 5A isoform X1

    Conserved Domains (1) summary
    pfam12480
    Location:118 → 177
    DUF3699; Protein of unknown function (DUF3699)

  3. XM_006541243.4 → XP_006541306.1  Golgi-associated RAB2 interactor protein 5A isoform X3

    UniProtKB/TrEMBL
    A0A0U1RNU0
    Related
    ENSMUSP00000145700.2, ENSMUST00000205359.2
    Conserved Domains (1) summary
    pfam12480
    Location:99 → 158
    DUF3699; Protein of unknown function (DUF3699)

  4. XM_036153517.1 → XP_036009410.1  Golgi-associated RAB2 interactor protein 5A isoform X7

    UniProtKB/TrEMBL
    B7XG50
    Conserved Domains (1) summary
    pfam12480
    Location:99 → 158
    DUF3699; Protein of unknown function (DUF3699)

  5. XM_036153516.1 → XP_036009409.1  Golgi-associated RAB2 interactor protein 5A isoform X5

    Conserved Domains (1) summary
    pfam12480
    Location:99 → 158
    DUF3699; Protein of unknown function (DUF3699)

  6. XM_030243057.2 → XP_030098917.1  Golgi-associated RAB2 interactor protein 5A isoform X12

    Conserved Domains (1) summary
    pfam12480
    Location:33 → 92
    DUF3699; Protein of unknown function (DUF3699)

  7. XM_030243059.2 → XP_030098919.1  Golgi-associated RAB2 interactor protein 5A isoform X14

    Conserved Domains (1) summary
    pfam12480
    Location:2 → 61
    DUF3699; Protein of unknown function (DUF3699)

  8. XM_036153519.1 → XP_036009412.1  Golgi-associated RAB2 interactor protein 5A isoform X15

    Conserved Domains (1) summary
    pfam12480
    Location:2 → 61
    DUF3699; Protein of unknown function (DUF3699)

  9. XM_030243058.2 → XP_030098918.1  Golgi-associated RAB2 interactor protein 5A isoform X13

    Conserved Domains (1) summary
    pfam12480
    Location:2 → 61
    DUF3699; Protein of unknown function (DUF3699)

  10. XM_006541248.3 → XP_006541311.1  Golgi-associated RAB2 interactor protein 5A isoform X9

    Conserved Domains (1) summary
    pfam12480
    Location:33 → 92
    DUF3699; Protein of unknown function (DUF3699)

  11. XM_036153518.1 → XP_036009411.1  Golgi-associated RAB2 interactor protein 5A isoform X11

    Conserved Domains (1) summary
    pfam12480
    Location:33 → 92
    DUF3699; Protein of unknown function (DUF3699)

  12. XM_011250907.4 → XP_011249209.1  Golgi-associated RAB2 interactor protein 5A isoform X8

    UniProtKB/TrEMBL
    B7XG50
    Conserved Domains (1) summary
    pfam12480
    Location:118 → 177
    DUF3699; Protein of unknown function (DUF3699)

  13. XM_036153515.1 → XP_036009408.1  Golgi-associated RAB2 interactor protein 5A isoform X2

    Conserved Domains (1) summary
    pfam12480
    Location:118 → 177
    DUF3699; Protein of unknown function (DUF3699)

  14. XM_006541244.5 → XP_006541307.1  Golgi-associated RAB2 interactor protein 5A isoform X4

    Conserved Domains (1) summary
    pfam12480
    Location:118 → 177
    DUF3699; Protein of unknown function (DUF3699)

  15. XM_006541245.5 → XP_006541308.1  Golgi-associated RAB2 interactor protein 5A isoform X6

    Conserved Domains (1) summary
    pfam12480
    Location:118 → 177
    DUF3699; Protein of unknown function (DUF3699)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1L3C1.2 GenPept UniProtKB/Swiss-Prot:A1L3C1

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