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Zbtb4 zinc finger and BTB domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 75580, updated on 2-Nov-2024

Summary

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Official Symbol
Zbtb4provided by MGI
Official Full Name
zinc finger and BTB domain containing 4provided by MGI
Primary source
MGI:MGI:1922830
See related
Ensembl:ENSMUSG00000018750 AllianceGenome:MGI:1922830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1538; 2310026P19Rik; 9230111I22Rik
Summary
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleotide binding activity; and protein homodimerization activity. Predicted to be involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear body. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system. Orthologous to human ZBTB4 (zinc finger and BTB domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 27.8), mammary gland adult (RPKM 15.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb4 in Genome Data Viewer
Location:
11 B3; 11 42.87 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69656738..69674852)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69765912..69784026)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide A Neighboring gene STARR-positive B cell enhancer ABC_E3966 Neighboring gene STARR-positive B cell enhancer ABC_E1830 Neighboring gene solute carrier family 35, member G3 Neighboring gene STARR-seq mESC enhancer starr_29866 Neighboring gene STARR-seq mESC enhancer starr_29867 Neighboring gene cholinergic receptor nicotinic beta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E7006 Neighboring gene fibroblast growth factor 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MSC-derived exosomes deliver ZBTB4 to mediate transcriptional repression of ITIH3 in astrocytes in spinal cord injury. Wu H, et al. Brain Res Bull, 2024 Jun 15. PMID 38641154
  2. Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis. Roussel-Gervais A, et al. Cancer Res, 2017 Jan 1. PMID 27815388
  3. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. Barrett CW, et al. PLoS One, 2012. PMID 23251453, Free PMC Article
  4. Discovery and validation of genes driving drug-intake and related behavioral traits in mice. Roy TA, et al. Genes Brain Behav, 2024 Jan 2. PMID 38164795, Free PMC Article
  5. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MSC-derived exosomes deliver ZBTB4 to mediate transcriptional repression of ITIH3 in astrocytes in spinal cord injury.
    Title: MSC-derived exosomes deliver ZBTB4 to mediate transcriptional repression of ITIH3 in astrocytes in spinal cord injury.
  2. we provide genetic evidence that the wild-type H-Ras and K-Ras proteins are bioequivalent in spite of their different structural and biological properties
    Title: Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyl-CpG binding IEA
Inferred from Electronic Annotation
more info
  
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables methyl-CpNpG binding IEA
Inferred from Electronic Annotation
more info
  
enables methyl-CpNpG binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363178.1 → NP_001350107.1  zinc finger and BTB domain-containing protein 4

    Status: VALIDATED

    Source sequence(s)
    AL603707
    Consensus CDS
    CCDS36197.2
    UniProtKB/Swiss-Prot
    Q3UHT8, Q5F293, Q69ZH0
    Related
    ENSMUSP00000104280.2, ENSMUST00000108640.8
    Conserved Domains (5) summary
    sd00017
    Location:287 → 307
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:212 → 228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:739 → 761
    zf-C2H2; Zinc finger, C2H2 type
    cd18195
    Location:12 → 160
    BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
    pfam13913
    Location:211 → 233
    zf-C2HC_2; zinc-finger of a C2HC-type

  2. NM_029348.2 → NP_083624.2  zinc finger and BTB domain-containing protein 4

    See identical proteins and their annotated locations for NP_083624.2

    Status: VALIDATED

    Source sequence(s)
    AK147212, BE943927, CA325272, CJ106077
    Consensus CDS
    CCDS36197.2
    UniProtKB/Swiss-Prot
    Q3UHT8, Q5F293, Q69ZH0
    Related
    ENSMUSP00000104279.2, ENSMUST00000108639.8
    Conserved Domains (5) summary
    sd00017
    Location:287 → 307
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:212 → 228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:739 → 761
    zf-C2H2; Zinc finger, C2H2 type
    cd18195
    Location:12 → 160
    BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
    pfam13913
    Location:211 → 233
    zf-C2HC_2; zinc-finger of a C2HC-type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69656738..69674852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249293.3 → XP_011247595.1  zinc finger and BTB domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011247595.1

    UniProtKB/Swiss-Prot
    Q3UHT8, Q5F293, Q69ZH0
    Conserved Domains (5) summary
    sd00017
    Location:287 → 307
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:212 → 228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:739 → 761
    zf-C2H2; Zinc finger, C2H2 type
    cd18195
    Location:12 → 160
    BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
    pfam13913
    Location:211 → 233
    zf-C2HC_2; zinc-finger of a C2HC-type

  2. XM_006534390.4 → XP_006534453.1  zinc finger and BTB domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006534453.1

    UniProtKB/Swiss-Prot
    Q3UHT8, Q5F293, Q69ZH0
    Conserved Domains (5) summary
    sd00017
    Location:287 → 307
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:212 → 228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:739 → 761
    zf-C2H2; Zinc finger, C2H2 type
    cd18195
    Location:12 → 160
    BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
    pfam13913
    Location:211 → 233
    zf-C2HC_2; zinc-finger of a C2HC-type

  3. XM_006534394.5 → XP_006534457.1  zinc finger and BTB domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006534457.1

    UniProtKB/Swiss-Prot
    Q3UHT8, Q5F293, Q69ZH0
    Conserved Domains (5) summary
    sd00017
    Location:287 → 307
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:212 → 228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:739 → 761
    zf-C2H2; Zinc finger, C2H2 type
    cd18195
    Location:12 → 160
    BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
    pfam13913
    Location:211 → 233
    zf-C2HC_2; zinc-finger of a C2HC-type

  4. XM_006534391.5 → XP_006534454.1  zinc finger and BTB domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006534454.1

    UniProtKB/Swiss-Prot
    Q3UHT8, Q5F293, Q69ZH0
    Conserved Domains (5) summary
    sd00017
    Location:287 → 307
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:212 → 228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:739 → 761
    zf-C2H2; Zinc finger, C2H2 type
    cd18195
    Location:12 → 160
    BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
    pfam13913
    Location:211 → 233
    zf-C2HC_2; zinc-finger of a C2HC-type

  5. XM_006534389.4 → XP_006534452.1  zinc finger and BTB domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006534452.1

    UniProtKB/Swiss-Prot
    Q3UHT8, Q5F293, Q69ZH0
    Conserved Domains (5) summary
    sd00017
    Location:287 → 307
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:212 → 228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:739 → 761
    zf-C2H2; Zinc finger, C2H2 type
    cd18195
    Location:12 → 160
    BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
    pfam13913
    Location:211 → 233
    zf-C2HC_2; zinc-finger of a C2HC-type

  6. XM_006534393.5 → XP_006534456.1  zinc finger and BTB domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006534456.1

    UniProtKB/Swiss-Prot
    Q3UHT8, Q5F293, Q69ZH0
    Conserved Domains (5) summary
    sd00017
    Location:287 → 307
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:212 → 228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:739 → 761
    zf-C2H2; Zinc finger, C2H2 type
    cd18195
    Location:12 → 160
    BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
    pfam13913
    Location:211 → 233
    zf-C2HC_2; zinc-finger of a C2HC-type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5F293.1 GenPept UniProtKB/Swiss-Prot:Q5F293

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