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Wnk2 WNK lysine deficient protein kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 75607, updated on 28-Oct-2024

Summary

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Official Symbol
Wnk2provided by MGI
Official Full Name
WNK lysine deficient protein kinase 2provided by MGI
Primary source
MGI:MGI:1922857
See related
Ensembl:ENSMUSG00000037989 AllianceGenome:MGI:1922857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESTM15; mKIAA1760; 1810073P09Rik
Summary
Predicted to enable potassium channel inhibitor activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Is expressed in central nervous system and neural retina. Orthologous to human WNK2 (WNK lysine deficient protein kinase 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in whole brain E14.5 (RPKM 9.8), cerebellum adult (RPKM 9.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Wnk2 in Genome Data Viewer
Location:
13 A5; 13 25.07 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49189778..49302110, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49036302..49148574, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 120, member A Neighboring gene family with sequence similarity 120A, opposite strand Neighboring gene kinesin family member 11 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34469 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49185630-49185783 Neighboring gene STARR-seq mESC enhancer starr_34472 Neighboring gene predicted gene, 40942 Neighboring gene predicted gene, 40943

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Early epigenetic downregulation of WNK2 kinase during pancreatic ductal adenocarcinoma development. Dutruel C, et al. Oncogene, 2014 Jun 26. PMID 23912455
  2. WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. Rinehart J, et al. J Biol Chem, 2011 Aug 26. PMID 21733846, Free PMC Article
  3. Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed. Izadifar A, et al. Neuron, 2021 Sep 15. PMID 34384519
  4. Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering. Tchernev VT, et al. Genomics, 1997 Feb 15. PMID 9070936
  5. Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Bettenhausen B, et al. Genomics, 1995 Aug 10. PMID 7490078

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase WNK2
Names
protein kinase lysine-deficient 2
protein kinase with no lysine 2
NP_001277240.1
NP_001277242.1
NP_083637.2
XP_006517037.1
XP_006517040.1
XP_006517042.1
XP_011242717.1
XP_011242718.1
XP_011242719.1
XP_011242720.1
XP_011242721.1
XP_011242722.1
XP_011242723.1
XP_011242724.1
XP_011242725.1
XP_011242726.1
XP_011242727.1
XP_011242728.1
XP_011242729.1
XP_017171115.1
XP_017171116.1
XP_030103304.1
XP_030103305.1
XP_030103306.1
XP_030103307.1
XP_030103308.1
XP_030103309.1
XP_030103310.1
XP_036014099.1
XP_036014100.1
XP_036014101.1
XP_036014102.1
XP_036014103.1
XP_036014104.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290311.1 → NP_001277240.1  serine/threonine-protein kinase WNK2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). This variant is partially supported by the mRNA AK044381.1; the 5' exon structure is inferred based on other transcript alignments at this gene.
    Source sequence(s)
    AA145730, AC160126, AK044381, AK147550, BM941970
    Consensus CDS
    CCDS70454.1
    UniProtKB/TrEMBL
    E0CYT1, E9QM73
    Related
    ENSMUSP00000089212.4, ENSMUST00000091623.10
    Conserved Domains (3) summary
    smart00220
    Location:200 → 453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  2. NM_001290313.1 → NP_001277242.1  serine/threonine-protein kinase WNK2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 3' exon structure, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. This variant is partially supported by the mRNA BC060187.1; the 5' exon structure is inferred based on other transcript alignments at this gene.
    Source sequence(s)
    AC160126, AI464179, AK147550, BC060187, BM941970
    Consensus CDS
    CCDS70455.1
    UniProtKB/TrEMBL
    E0CYT1, E9QMI8
    Related
    ENSMUSP00000105724.3, ENSMUST00000110097.9
    Conserved Domains (3) summary
    smart00220
    Location:200 → 453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  3. NM_029361.4 → NP_083637.2  serine/threonine-protein kinase WNK2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons and contains alternate 3' exon structure, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a. This variant is mostly supported by the mRNA AK147550.1, but with correction of a non-consensus splice site.
    Source sequence(s)
    AC160126, AI464179, AK147550, BM941970
    UniProtKB/TrEMBL
    E0CZE3
    Related
    ENSMUSP00000125448.2, ENSMUST00000162581.8
    Conserved Domains (3) summary
    smart00220
    Location:200 → 453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    49189778..49302110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158211.1 → XP_036014104.1  serine/threonine-protein kinase WNK2 isoform X31

    UniProtKB/TrEMBL
    E9Q6Q2
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 988
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  2. XM_036158210.1 → XP_036014103.1  serine/threonine-protein kinase WNK2 isoform X29

    UniProtKB/TrEMBL
    E9Q6Q2
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 988
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  3. XM_006516979.3 → XP_006517042.1  serine/threonine-protein kinase WNK2 isoform X28

    UniProtKB/TrEMBL
    E9Q6Q2
    Related
    ENSMUSP00000125539.2, ENSMUST00000162403.8
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 988
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  4. XM_036158208.1 → XP_036014101.1  serine/threonine-protein kinase WNK2 isoform X25

    UniProtKB/TrEMBL
    E0CZE3
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1036
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  5. XM_036158207.1 → XP_036014100.1  serine/threonine-protein kinase WNK2 isoform X24

    UniProtKB/TrEMBL
    E0CZE3
    Conserved Domains (4) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    NF033761
    Location:1323 → 1479
    gliding_GltJ; adventurous gliding motility protein GltJ

  6. XM_030247449.1 → XP_030103309.1  serine/threonine-protein kinase WNK2 isoform X21

    UniProtKB/TrEMBL
    E0CZE3
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  7. XM_030247447.2 → XP_030103307.1  serine/threonine-protein kinase WNK2 isoform X17

    UniProtKB/TrEMBL
    E9QJQ9
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  8. XM_030247446.1 → XP_030103306.1  serine/threonine-protein kinase WNK2 isoform X14

    UniProtKB/TrEMBL
    E9QJQ9
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  9. XM_036158206.1 → XP_036014099.1  serine/threonine-protein kinase WNK2 isoform X10

    UniProtKB/TrEMBL
    E0CYT1
    Conserved Domains (4) summary
    PHA03247
    Location:700 → 1136
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    NF033761
    Location:1323 → 1479
    gliding_GltJ; adventurous gliding motility protein GltJ

  10. XM_011244426.2 → XP_011242728.1  serine/threonine-protein kinase WNK2 isoform X23

    UniProtKB/TrEMBL
    E0CZE3
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  11. XM_017315627.2 → XP_017171116.1  serine/threonine-protein kinase WNK2 isoform X20

    UniProtKB/TrEMBL
    E0CZE3
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  12. XM_030247448.1 → XP_030103308.1  serine/threonine-protein kinase WNK2 isoform X18

    UniProtKB/TrEMBL
    E0CZE3
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  13. XM_011244425.2 → XP_011242727.1  serine/threonine-protein kinase WNK2 isoform X16

    UniProtKB/TrEMBL
    E9QJQ9
    Related
    ENSMUSP00000049327.9, ENSMUST00000049265.15
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  14. XM_017315626.2 → XP_017171115.1  serine/threonine-protein kinase WNK2 isoform X13

    UniProtKB/TrEMBL
    E9QJQ9
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  15. XM_030247445.1 → XP_030103305.1  serine/threonine-protein kinase WNK2 isoform X11

    UniProtKB/TrEMBL
    E0CYT1
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  16. XM_011244422.2 → XP_011242724.1  serine/threonine-protein kinase WNK2 isoform X9

    UniProtKB/TrEMBL
    E0CYT1
    Conserved Domains (3) summary
    PHA03247
    Location:700 → 1136
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  17. XM_011244415.4 → XP_011242717.1  serine/threonine-protein kinase WNK2 isoform X1

    UniProtKB/TrEMBL
    E0CYT1
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  18. XM_036158209.1 → XP_036014102.1  serine/threonine-protein kinase WNK2 isoform X26

    UniProtKB/TrEMBL
    E9Q6Q2
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 988
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  19. XM_006516974.4 → XP_006517037.1  serine/threonine-protein kinase WNK2 isoform X19

    UniProtKB/TrEMBL
    E9Q6Q2
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 988
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  20. XM_011244416.3 → XP_011242718.1  serine/threonine-protein kinase WNK2 isoform X2

    UniProtKB/TrEMBL
    E0CYT1
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  21. XM_011244424.3 → XP_011242726.1  serine/threonine-protein kinase WNK2 isoform X15

    UniProtKB/TrEMBL
    E0CZE3
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  22. XM_011244423.3 → XP_011242725.1  serine/threonine-protein kinase WNK2 isoform X12

    UniProtKB/TrEMBL
    E0CZE3
    Conserved Domains (3) summary
    PHA03247
    Location:700 → 1136
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  23. XM_011244421.3 → XP_011242723.1  serine/threonine-protein kinase WNK2 isoform X8

    UniProtKB/TrEMBL
    E0CZE3
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  24. XM_011244420.3 → XP_011242722.1  serine/threonine-protein kinase WNK2 isoform X6

    UniProtKB/TrEMBL
    E9QJQ9
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  25. XM_030247444.1 → XP_030103304.1  serine/threonine-protein kinase WNK2 isoform X7

    UniProtKB/TrEMBL
    E9QJQ9
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  26. XM_011244419.3 → XP_011242721.1  serine/threonine-protein kinase WNK2 isoform X5

    UniProtKB/TrEMBL
    E9QJQ9
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  27. XM_011244417.3 → XP_011242719.1  serine/threonine-protein kinase WNK2 isoform X3

    UniProtKB/TrEMBL
    E0CYT1
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  28. XM_011244418.2 → XP_011242720.1  serine/threonine-protein kinase WNK2 isoform X4

    UniProtKB/TrEMBL
    E0CYT1
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 1068
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  29. XM_011244427.4 → XP_011242729.1  serine/threonine-protein kinase WNK2 isoform X27

    UniProtKB/Swiss-Prot
    Q3UH66, Q3V387, Q6PAN9, Q6ZPI6, Q7TNS1, Q811F2
    Conserved Domains (4) summary
    PHA03247
    Location:464 → 824
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:1025 → 1513
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam12202
    Location:230 → 293
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    cl21453
    Location:1 → 214
    PKc_like; Protein Kinases, catalytic domain

  30. XM_030247450.2 → XP_030103310.1  serine/threonine-protein kinase WNK2 isoform X30

    UniProtKB/Swiss-Prot
    Q3UH66, Q3V387, Q6PAN9, Q6ZPI6, Q7TNS1, Q811F2
    Conserved Domains (4) summary
    PHA03247
    Location:464 → 792
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:989 → 1477
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam12202
    Location:230 → 293
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    cl21453
    Location:1 → 214
    PKc_like; Protein Kinases, catalytic domain

  31. XM_006516977.4 → XP_006517040.1  serine/threonine-protein kinase WNK2 isoform X22

    UniProtKB/TrEMBL
    E9Q6Q2, E9QMI9
    Related
    ENSMUSP00000105723.2, ENSMUST00000110096.8
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 988
    PHA03247; large tegument protein UL36; Provisional
    cd14032
    Location:193 → 458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474 → 537
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UH66.2 GenPept UniProtKB/Swiss-Prot:Q3UH66

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