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Rilpl1 Rab interacting lysosomal protein-like 1 [ Mus musculus (house mouse) ]

Gene ID: 75695, updated on 28-Oct-2024

Summary

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Official Symbol
Rilpl1provided by MGI
Official Full Name
Rab interacting lysosomal protein-like 1provided by MGI
Primary source
MGI:MGI:1922945
See related
Ensembl:ENSMUSG00000029392 AllianceGenome:MGI:1922945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GOSPEL; 2900002H16Rik; 6330559I19Rik
Summary
Predicted to enable dynein light intermediate chain binding activity and small GTPase binding activity. Involved in epithelial cell morphogenesis and protein transport from ciliary membrane to plasma membrane. Located in centrosome and cilium. Is expressed in several structures, including brain; genitourinary system; gut; lens; and vertebral axis musculature. Human ortholog(s) of this gene implicated in oculopharyngodistal myopathy 4. Orthologous to human RILPL1 (Rab interacting lysosomal protein like 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in heart adult (RPKM 23.7), cortex adult (RPKM 9.6) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Rilpl1 in Genome Data Viewer
Location:
5 63.62 cM; 5 F
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124631143..124669684, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124493080..124531441, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Rab interacting lysosomal protein-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E8082 Neighboring gene STARR-positive B cell enhancer ABC_E11302 Neighboring gene STARR-positive B cell enhancer ABC_E2178 Neighboring gene peptidylprolyl isomerase A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6382 Neighboring gene STARR-positive B cell enhancer ABC_E10352 Neighboring gene small nuclear ribonucleoprotein 35 (U11/U12) Neighboring gene predicted gene, 52789 Neighboring gene ribosomal protein L32 5C pseudogene Neighboring gene transmembrane p24 trafficking protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E3619 Neighboring gene STARR-positive B cell enhancer ABC_E3620 Neighboring gene DEAD box helicase 55

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content. Schaub JR, et al. Mol Biol Cell, 2013 Feb. PMID 23264467, Free PMC Article
  2. GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Sen N, et al. Neuron, 2009 Jul 16. PMID 19607794, Free PMC Article
  3. Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes. Ohbayashi N, et al. J Cell Sci, 2012 Mar 15. PMID 22275436
  4. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
  5. A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Kalsotra A, et al. Proc Natl Acad Sci U S A, 2008 Dec 23. PMID 19075228, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ39378

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport from ciliary membrane to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RILP-like protein 1
Names
rab-interacting lysosomal-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417895.1 → NP_001404824.1  RILP-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC127313

  2. NM_001417896.1 → NP_001404825.1  RILP-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127313

  3. NM_021430.3 → NP_067405.1  RILP-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_067405.1

    Status: VALIDATED

    Source sequence(s)
    AC127313
    Consensus CDS
    CCDS19678.1
    UniProtKB/Swiss-Prot
    Q80WV8, Q9JJC6
    Related
    ENSMUSP00000050014.8, ENSMUST00000062153.12
    Conserved Domains (3) summary
    TIGR02169
    Location:76 → 322
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam09744
    Location:28 → 174
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam11461
    Location:299 → 351
    RILP; Rab interacting lysosomal protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124631143..124669684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248246.4 → XP_011246548.1  RILP-like protein 1 isoform X3

    Conserved Domains (3) summary
    TIGR02169
    Location:76 → 322
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam09744
    Location:28 → 174
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam11461
    Location:299 → 351
    RILP; Rab interacting lysosomal protein

  2. XM_006530491.5 → XP_006530554.1  RILP-like protein 1 isoform X4

    Conserved Domains (3) summary
    TIGR02169
    Location:76 → 322
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam09744
    Location:28 → 174
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam11461
    Location:299 → 351
    RILP; Rab interacting lysosomal protein

  3. XM_011248245.4 → XP_011246547.1  RILP-like protein 1 isoform X2

    Conserved Domains (3) summary
    TIGR02169
    Location:76 → 322
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam09744
    Location:28 → 174
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam11461
    Location:299 → 351
    RILP; Rab interacting lysosomal protein

  4. XM_036165584.1 → XP_036021477.1  RILP-like protein 1 isoform X6

    Conserved Domains (3) summary
    TIGR02169
    Location:76 → 322
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam09744
    Location:27 → 174
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam11461
    Location:299 → 351
    RILP; Rab interacting lysosomal protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJC6.1 GenPept UniProtKB/Swiss-Prot:Q9JJC6

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