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Ces1h carboxylesterase 1H [ Mus musculus (house mouse) ]

Gene ID: 75704, updated on 2-Nov-2024

Summary

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Official Symbol
Ces1hprovided by MGI
Official Full Name
carboxylesterase 1Hprovided by MGI
Primary source
MGI:MGI:1922954
See related
Ensembl:ENSMUSG00000074156 AllianceGenome:MGI:1922954
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310039D24Rik
Summary
Predicted to enable carboxylesterase activity and sterol ester esterase activity. Predicted to be involved in several processes, including cellular response to cholesterol; cholesterol homeostasis; and regulation of steroid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in endoplasmic reticulum and lipid droplet. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in lung adult (RPKM 1.8), testis adult (RPKM 0.4) and 1 other tissue See more
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Genomic context

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See Ces1h in Genome Data Viewer
Location:
8 C5; 8 45.38 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94078468..94106405, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93351840..93379777, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxylesterase 1F Neighboring gene carboxylesterase 1G Neighboring gene STARR-seq mESC enhancer starr_22334 Neighboring gene STARR-seq mESC enhancer starr_22335 Neighboring gene STARR-seq mESC enhancer starr_22336 Neighboring gene predicted gene, 30132 Neighboring gene STARR-seq mESC enhancer starr_22337 Neighboring gene carboxylesterase 5A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
  2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sterol ester esterase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in medium-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cholesterol storage ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of bile acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in reverse cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
carboxylesterase 1H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370830.1 → NP_001357759.1  carboxylesterase 1H precursor

    Status: VALIDATED

    Source sequence(s)
    AC162945, AC162949
    Consensus CDS
    CCDS90436.1
    UniProtKB/TrEMBL
    D3Z298
    Related
    ENSMUSP00000121729.3, ENSMUST00000145041.4
    Conserved Domains (1) summary
    pfam00135
    Location:24 → 546
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    94078468..94106405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531545.2 → XP_006531608.1  carboxylesterase 1H isoform X1

    See identical proteins and their annotated locations for XP_006531608.1

    Conserved Domains (1) summary
    pfam00135
    Location:2 → 462
    COesterase; Carboxylesterase family

  2. XM_006531546.2 → XP_006531609.1  carboxylesterase 1H isoform X2

    See identical proteins and their annotated locations for XP_006531609.1

    Conserved Domains (1) summary
    pfam00135
    Location:1 → 410
    COesterase; Carboxylesterase family
Nucleotide Protein Strain
Heading Accession and Version

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Research Materials