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ZNF32 zinc finger protein 32 [ Homo sapiens (human) ]

Gene ID: 7580, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF32provided by HGNC
Official Full Name
zinc finger protein 32provided by HGNC
Primary source
HGNC:HGNC:13095
See related
Ensembl:ENSG00000169740 MIM:194539; AllianceGenome:HGNC:13095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX30; ZNF637; Zfp637
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 6.7), thyroid (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
10q11.21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (43643862..43648881, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (44524781..44529800, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (44139310..44144329, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2335 Neighboring gene zinc finger protein 485 Neighboring gene uncharacterized LOC124902416 Neighboring gene ZNF32 antisense RNA 3 Neighboring gene ribosomal protein L21 pseudogene 88 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:44141084-44142283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2336 Neighboring gene ZNF32 antisense RNA 1 Neighboring gene ZNF32 antisense RNA 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:44162766-44162945 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_12364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2337 Neighboring gene uncharacterized LOC124902417 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_12372 Neighboring gene SPRING1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF32 inhibits autophagy through the mTOR pathway and protects MCF-7 cells from stimulus-induced cell death. Li Y, et al. Sci Rep, 2015 Mar 19. PMID 25786368, Free PMC Article
  2. C2H2-546: a zinc finger protein differentially expressed in HTLV-1 infected T cells. Drew PD, et al. J Neurovirol, 1997 Dec. PMID 9475118
  3. ZNF32 prevents the activation of cancer-associated fibroblasts through negative regulation of TGFB1 transcription in breast cancer. Li Q, et al. FASEB J, 2023 Apr. PMID 36934389
  4. Zinc finger protein 32 promotes breast cancer stem cell-like properties through directly promoting GPER transcription. Li Y, et al. Cell Death Dis, 2018 Nov 26. PMID 30478301, Free PMC Article
  5. ZNF32 induces anoikis resistance through maintaining redox homeostasis and activating Src/FAK signaling in hepatocellular carcinoma. Li K, et al. Cancer Lett, 2019 Feb 1. PMID 30439540

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF32 prevents the activation of cancer-associated fibroblasts through negative regulation of TGFB1 transcription in breast cancer.
    Title: ZNF32 prevents the activation of cancer-associated fibroblasts through negative regulation of TGFB1 transcription in breast cancer.
  2. ZNF32 promotes the self-renewal of colorectal cancer cells by regulating the LEPR-STAT3 signaling pathway.
    Title: ZNF32 promotes the self-renewal of colorectal cancer cells by regulating the LEPR-STAT3 signaling pathway.
  3. We conclude that ZNF32 can engage GPER/ERK signalling and confer breast cancer stem cell-like properties, which may indicate poor prognosis of breast cancer patients. ZNF32 and GPER targeted therapies might provide new solutions for breast cancer treatment.
    Title: Zinc finger protein 32 promotes breast cancer stem cell-like properties through directly promoting GPER transcription.
  4. ZNF32 contributes to anoikis resistance by maintaining redox homeostasis and activating Src/FAK signaling in HepG2 cells.
    Title: ZNF32 induces anoikis resistance through maintaining redox homeostasis and activating Src/FAK signaling in hepatocellular carcinoma.
  5. ZNF32 was found to directly bind to the TGF-betaR2 (transforming growth factor-beta receptor 2) promoter to promote its expression.
    Title: ZNF32 contributes to the induction of multidrug resistance by regulating TGF-β receptor 2 signaling in lung adenocarcinoma.
  6. Sp1-ZNF32-C1QBP axis protects against oxidative stress/apoptosis in hepatocellular carcinoma cells.
    Title: ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription.
  7. ZNF32 acts as an effective autophagy inhibitor to protect breast cancer cells from excessive stimulus-autophagy-induced cell death.
    Title: ZNF32 inhibits autophagy through the mTOR pathway and protects MCF-7 cells from stimulus-induced cell death.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger protein 32
Names
C2H2-546
zinc finger protein 32 (KOX 30)
zinc finger protein KOX30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005368.3 → NP_001005368.1  zinc finger protein 32 isoform a

    See identical proteins and their annotated locations for NP_001005368.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    BC022842, HY045180
    Consensus CDS
    CCDS7206.1
    UniProtKB/Swiss-Prot
    P17041, Q92951
    Related
    ENSP00000379143.1, ENST00000395797.1
    Conserved Domains (2) summary
    COG5048
    Location:47 → 237
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:79 → 99
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001324164.2 → NP_001311093.1  zinc finger protein 32 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) and variant 4 both encode the same isoform (b).
    Source sequence(s)
    AL645634
    Conserved Domains (2) summary
    COG5048
    Location:51 → 241
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:83 → 103
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001324165.2 → NP_001311094.1  zinc finger protein 32 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) and variant 3 both encode the same isoform (b).
    Source sequence(s)
    BC022842, HY045180, HY148951
    UniProtKB/Swiss-Prot
    P17041
    Conserved Domains (2) summary
    COG5048
    Location:51 → 241
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:83 → 103
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001324166.2 → NP_001311095.1  zinc finger protein 32 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 6 and 7, encodes isoform c.
    Source sequence(s)
    AL645634
    Conserved Domains (2) summary
    COG5048
    Location:22 → 212
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:54 → 74
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001324167.2 → NP_001311096.1  zinc finger protein 32 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 5 and 7, encodes isoform c.
    Source sequence(s)
    AL645634
    Conserved Domains (2) summary
    COG5048
    Location:22 → 212
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:54 → 74
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001324168.2 → NP_001311097.1  zinc finger protein 32 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 5 and 6, encodes isoform c.
    Source sequence(s)
    BC022842, HY045180
    UniProtKB/Swiss-Prot
    P17041
    Conserved Domains (2) summary
    COG5048
    Location:22 → 212
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:54 → 74
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_006973.3 → NP_008904.1  zinc finger protein 32 isoform a

    See identical proteins and their annotated locations for NP_008904.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the more frequently occurring variant. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL645634, BC022842, BG477527
    Consensus CDS
    CCDS7206.1
    UniProtKB/Swiss-Prot
    P17041, Q92951
    Related
    ENSP00000363556.2, ENST00000374433.7
    Conserved Domains (2) summary
    COG5048
    Location:47 → 237
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:79 → 99
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    43643862..43648881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    44524781..44529800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17041.2 GenPept UniProtKB/Swiss-Prot:P17041

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