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ZNF33A zinc finger protein 33A [ Homo sapiens (human) ]

Gene ID: 7581, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF33Aprovided by HGNC
Official Full Name
zinc finger protein 33Aprovided by HGNC
Primary source
HGNC:HGNC:13096
See related
Ensembl:ENSG00000189180 MIM:194521; AllianceGenome:HGNC:13096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX2; KOX5; KOX31; NF11A; ZNF11; ZNF33; ZZAPK; ZNF11A
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 6.2), prostate (RPKM 5.2) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF33A in Genome Data Viewer
Location:
10p11.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (38010489..38067834)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (38054130..38111817)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (38299578..38356762)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 25 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3272 Neighboring gene ZNF25 divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr10:38274009-38274157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3273 Neighboring gene RNA, U6 small nuclear 795, pseudogene Neighboring gene eukaryotic translation initiation factor 3 subunit L pseudogene 3 Neighboring gene FXYD domain containing ion transport regulator 6 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF711 puts a spell on DNA. Kooy RF. Eur J Hum Genet, 2022 Apr. PMID 35132177, Free PMC Article
  2. Genome-wide copy number variation-, validation- and screening study implicates a new copy number polymorphism associated with suicide attempts in major depressive disorder. Rao S, et al. Gene, 2020 Sep 10. PMID 32554045
  3. A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle. Yang JJ. Biochem Biophys Res Commun, 2003 Jan 31. PMID 12535642
  4. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. Tunnacliffe A, et al. Nucleic Acids Res, 1993 Mar 25. PMID 8464732, Free PMC Article
  5. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. Huebner K, et al. Am J Hum Genet, 1991 Apr. PMID 2014798, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF711 puts a spell on DNA.
    Title: ZNF711 puts a spell on DNA.
  2. Genome-wide copy number variation-, validation- and screening study implicates a new copy number polymorphism associated with suicide attempts in major depressive disorder.
    Title: Genome-wide copy number variation-, validation- and screening study implicates a new copy number polymorphism associated with suicide attempts in major depressive disorder.
  3. Results suggest that ZAK might play a role as an upstream signal to suppress the ZZaPK function and decrease E2F expression.
    Title: A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23404, KIAA0065

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 33A
Names
brain my041 protein
zinc finger and ZAK-associated protein with KRAB domain
zinc finger protein 11A
zinc finger protein 33a (KOX 31)
zinc finger protein KOX31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278170.2 → NP_001265099.1  zinc finger protein 33A isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks the exon containing the translation start site and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (c) has a longer and distinct N-terminus and lacks an aa near the C-terminus compared to isoform a.
    Source sequence(s)
    AK303445, CD679489, D31763
    Consensus CDS
    CCDS60514.1
    UniProtKB/Swiss-Prot
    Q06730
    Related
    ENSP00000485869.1, ENST00000628825.2
    Conserved Domains (5) summary
    smart00349
    Location:19 → 78
    KRAB; krueppel associated box
    COG5048
    Location:429 → 805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365 → 385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:19 → 58
    KRAB; KRAB box
    pfam13465
    Location:377 → 402
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001278171.2 → NP_001265100.1  zinc finger protein 33A isoform d

    See identical proteins and their annotated locations for NP_001265100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon before the last exon compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (d) with a shorter N-terminus compared to isoform a. Variants 4, 6, and 10-14 all encode the same isoform (d).
    Source sequence(s)
    AK292844, AL161931, AL712670, CD679489, D31763, DB235703
    Consensus CDS
    CCDS73089.1
    UniProtKB/TrEMBL
    A0A0A0MRS1
    Conserved Domains (3) summary
    COG5048
    Location:217 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259 → 284
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001278173.1 → NP_001265102.1  zinc finger protein 33A isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (e) initiates translation in the alternate exon, so isoform e has a longer and distinct N-terminus compared to isoform a.
    Source sequence(s)
    CD679489, D31763, DB234051, DB235703
    Consensus CDS
    CCDS73088.1
    UniProtKB/TrEMBL
    A0A0A0MR11
    Related
    ENSP00000304268.10, ENST00000307441.13
    Conserved Domains (5) summary
    smart00349
    Location:30 → 89
    KRAB; krueppel associated box
    COG5048
    Location:347 → 692
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:30 → 69
    KRAB; KRAB box
    pfam13465
    Location:389 → 414
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001278174.2 → NP_001265103.1  zinc finger protein 33A isoform d

    See identical proteins and their annotated locations for NP_001265103.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate exon before the last exon compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (d) with a shorter N-terminus compared to isoform a. Variants 4, 6, and 10-14 all encode the same isoform (d).
    Source sequence(s)
    AL161931, CD679489, D31763, DA276183, DB235703
    Consensus CDS
    CCDS73089.1
    UniProtKB/TrEMBL
    A0A0A0MRS1
    Conserved Domains (3) summary
    COG5048
    Location:217 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259 → 284
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001278175.2 → NP_001265104.1  zinc finger protein 33A isoform f

    See identical proteins and their annotated locations for NP_001265104.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains an alternate exon before the last exon compared to variant 1. Translation of this variant begins in the alternate exon, so the resulting isoform (f) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL161931, CD679489, D31763, DB134021, DB235703
    UniProtKB/Swiss-Prot
    Q06730
    Conserved Domains (3) summary
    COG5048
    Location:251 → 596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:281 → 301
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:293 → 318
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001278176.2 → NP_001265105.1  zinc finger protein 33A isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains an alternate exon before the last exon compared to variant 1. Translation of this variant begins at a downstream AUG compared to variant 1, so the resulting isoform (g) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AI300433, AL161931, CD679489, D31763, DB235703
    UniProtKB/Swiss-Prot
    Q06730
    Conserved Domains (3) summary
    COG5048
    Location:286 → 631
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:328 → 353
    zf-H2C2_2; Zinc-finger double domain

  7. NM_001278177.2 → NP_001265106.1  zinc finger protein 33A isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (h) has a longer and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL161931, BF435065, CD679489, D31763, DB235703
    UniProtKB/Swiss-Prot
    Q06730
    Conserved Domains (5) summary
    smart00349
    Location:33 → 92
    KRAB; krueppel associated box
    COG5048
    Location:444 → 820
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380 → 400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:33 → 72
    KRAB; KRAB box
    pfam13465
    Location:392 → 417
    zf-H2C2_2; Zinc-finger double domain

  8. NM_001278178.1 → NP_001265107.1  zinc finger protein 33A isoform d

    See identical proteins and their annotated locations for NP_001265107.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) uses an alternate splice junction at the 3' end of a coding exon compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (d) with a shorter N-terminus compared to isoform a. Variants 4, 6, and 10-14 all encode the same isoform (d).
    Source sequence(s)
    CD679489, D31763, DA757208, DB235703
    Consensus CDS
    CCDS73089.1
    UniProtKB/TrEMBL
    A0A0A0MRS1
    Related
    ENSP00000363747.4, ENST00000374618.7
    Conserved Domains (3) summary
    COG5048
    Location:217 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259 → 284
    zf-H2C2_2; Zinc-finger double domain

  9. NM_001278179.2 → NP_001265108.1  zinc finger protein 33A isoform d

    See identical proteins and their annotated locations for NP_001265108.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) contains an alternate exon before the last exon and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. These differences cause translation initiation at a downstream AUG and results in an isoform (d) with a shorter N-terminus compared to isoform a. Variants 4, 6, and 10-14 all encode the same isoform (d).
    Source sequence(s)
    AL712670, CD679489, D31763, DB235703
    Consensus CDS
    CCDS73089.1
    UniProtKB/TrEMBL
    A0A0A0MRS1
    Conserved Domains (3) summary
    COG5048
    Location:217 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259 → 284
    zf-H2C2_2; Zinc-finger double domain

  10. NM_001324175.2 → NP_001311104.1  zinc finger protein 33A isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 4, 6, 10-11, and 13-14, encodes isoform d.
    Source sequence(s)
    AL117337, AL161931
    Consensus CDS
    CCDS73089.1
    UniProtKB/TrEMBL
    A0A0A0MRS1
    Conserved Domains (3) summary
    COG5048
    Location:217 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259 → 284
    zf-H2C2_2; Zinc-finger double domain

  11. NM_001324176.2 → NP_001311105.1  zinc finger protein 33A isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 4, 6, 10-12, and 14, encodes isoform d.
    Source sequence(s)
    AL117337, AL161931
    Consensus CDS
    CCDS73089.1
    UniProtKB/TrEMBL
    A0A0A0MRS1
    Conserved Domains (3) summary
    COG5048
    Location:217 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259 → 284
    zf-H2C2_2; Zinc-finger double domain

  12. NM_001324177.2 → NP_001311106.1  zinc finger protein 33A isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 4, 6, and 10-13, encodes isoform d.
    Source sequence(s)
    AL117337, AL161931
    Consensus CDS
    CCDS73089.1
    UniProtKB/TrEMBL
    A0A0A0MRS1
    Conserved Domains (3) summary
    COG5048
    Location:217 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259 → 284
    zf-H2C2_2; Zinc-finger double domain

  13. NM_001324178.2 → NP_001311107.1  zinc finger protein 33A isoform i

    Status: VALIDATED

    Source sequence(s)
    AL117337, AL161931

  14. NM_006954.2 → NP_008885.1  zinc finger protein 33A isoform a

    See identical proteins and their annotated locations for NP_008885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform a.
    Source sequence(s)
    AL161931, CD679489, D31763, DB235703
    Consensus CDS
    CCDS44372.1
    UniProtKB/Swiss-Prot
    Q06730
    Related
    ENSP00000402467.3, ENST00000432900.7
    Conserved Domains (5) summary
    smart00349
    Location:12 → 71
    KRAB; krueppel associated box
    COG5048
    Location:423 → 799
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:359 → 379
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 51
    KRAB; KRAB box
    pfam13465
    Location:371 → 396
    zf-H2C2_2; Zinc-finger double domain

  15. NM_006974.3 → NP_008905.1  zinc finger protein 33A isoform b

    See identical proteins and their annotated locations for NP_008905.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    CD679489, D31763, DB235703
    Consensus CDS
    CCDS31182.1
    UniProtKB/Swiss-Prot
    A8K9X9, B4E0M8, F6TH33, F8WAJ5, P17013, Q06730, Q5VZ86
    Related
    ENSP00000387713.2, ENST00000458705.6
    Conserved Domains (5) summary
    smart00349
    Location:12 → 71
    KRAB; krueppel associated box
    COG5048
    Location:328 → 673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:358 → 378
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 51
    KRAB; KRAB box
    pfam13465
    Location:370 → 395
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_136709.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337, AL161931

  2. NR_136710.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337, AL161931

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    38010489..38067834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519650.3 → XP_011517952.1  zinc finger protein 33A isoform X3

    See identical proteins and their annotated locations for XP_011517952.1

    UniProtKB/Swiss-Prot
    Q06730
    Conserved Domains (5) summary
    smart00349
    Location:12 → 71
    KRAB; krueppel associated box
    COG5048
    Location:423 → 799
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:359 → 379
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 51
    KRAB; KRAB box
    pfam13465
    Location:371 → 396
    zf-H2C2_2; Zinc-finger double domain

  2. XM_017016617.2 → XP_016872106.1  zinc finger protein 33A isoform X1

  3. XM_011519651.3 → XP_011517953.1  zinc finger protein 33A isoform X4

    See identical proteins and their annotated locations for XP_011517953.1

    UniProtKB/Swiss-Prot
    A8K9X9, B4E0M8, F6TH33, F8WAJ5, P17013, Q06730, Q5VZ86
    Conserved Domains (5) summary
    smart00349
    Location:12 → 71
    KRAB; krueppel associated box
    COG5048
    Location:328 → 673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:358 → 378
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 51
    KRAB; KRAB box
    pfam13465
    Location:370 → 395
    zf-H2C2_2; Zinc-finger double domain

  4. XM_011519654.3 → XP_011517956.1  zinc finger protein 33A isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:250 → 595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:280 → 300
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:292 → 317
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    38054130..38111817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366690.1 → XP_054222665.1  zinc finger protein 33A isoform X6

  2. XM_054366689.1 → XP_054222664.1  zinc finger protein 33A isoform X5

  3. XM_054366691.1 → XP_054222666.1  zinc finger protein 33A isoform X1

  4. XM_054366692.1 → XP_054222667.1  zinc finger protein 33A isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06730.3 GenPept UniProtKB/Swiss-Prot:Q06730

Gene LinkOut

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