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Oga O-GlcNAcase [ Mus musculus (house mouse) ]

Gene ID: 76055, updated on 2-Nov-2024

Summary

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Official Symbol
Ogaprovided by MGI
Official Full Name
O-GlcNAcaseprovided by MGI
Primary source
MGI:MGI:1932139
See related
Ensembl:ENSMUSG00000025220 AllianceGenome:MGI:1932139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hy5; Mgea5; Ncoat
Summary
Predicted to enable histone acetyltransferase activity; hydrolase activity, hydrolyzing O-glycosyl compounds; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of mitochondrial depolarization; positive regulation of transport; and regulation of protein metabolic process. Predicted to be located in cytosol. Is expressed in brain; liver; and retina nuclear layer. Orthologous to human OGA (O-GlcNAcase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 28.1), CNS E11.5 (RPKM 27.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Oga in Genome Data Viewer
Location:
19 C3; 19 38.75 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45738698..45772274, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45750255..45783644, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene Fgf8 enhancer CR1 Neighboring gene STARR-positive B cell enhancer ABC_E11033 Neighboring gene fibroblast growth factor 8 Neighboring gene nucleoplasmin 3 Neighboring gene STARR-positive B cell enhancer ABC_E4286 Neighboring gene STARR-seq mESC enhancer starr_46285 Neighboring gene Kv channel-interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_46286 Neighboring gene armadillo-like helical domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E7665 Neighboring gene ribosomal protein L21 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pancreatic β-cell hyper-O-GlcNAcylation leads to impaired glucose homeostasis in vivo. Jo S, et al. Front Endocrinol (Lausanne), 2022. PMID 36387851, Free PMC Article
  2. Streptozotocin inhibits O-GlcNAcase via the production of a transition state analog. Toleman C, et al. Biochem Biophys Res Commun, 2006 Feb 10. PMID 16376298
  3. Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice. Cabrera JT, et al. Diab Vasc Dis Res, 2023 May-Jun. PMID 37186669, Free PMC Article
  4. Terminal differentiation program of skeletal myogenesis is negatively regulated by O-GlcNAc glycosylation. Ogawa M, et al. Biochim Biophys Acta, 2012 Jan. PMID 22056510
  5. Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis. Keembiyehetty C, et al. J Biol Chem, 2015 Mar 13. PMID 25596529, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice.
    Title: Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice.
  2. Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice.
    Title: Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice.
  3. Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis.
    Title: Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis.
  4. Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
    Title: Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
  5. Furthermore, both Ogt and Oga were required for the reversion from primed ESD-EpiSCs to naive rESCs. These findings indicate that O-GlcNAcylation plays an important role in the survival of primed ESD-EpiSCs and in their reversion to naive rESCs.
    Title: O-GlcNAc is required for the survival of primed pluripotent stem cells and their reversion to the naïve state.
  6. the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT) and O-GlcNAcase (OGA), interact with the (A)gamma-globin promoter at the -566 GATA repressor site
    Title: O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the Aγ-Globin Promoter.
  7. Oga(+/-) mice resist high-fat diet-induced obesity with ameliorated hepatic steatosis and improved glucose metabolism
    Title: Obesity resistance and increased energy expenditure by white adipose tissue browning in Oga(+/-) mice.
  8. plays a critical role in placental vasculogenesis by modulating HIF-1alpha stabilization
    Title: O-GlcNAc cycling enzymes control vascular development of the placenta by modulating the levels of HIF-1α.
  9. E2F1 negatively regulates both Ogt and Mgea5 expression in an Rb1 protein-dependent manner.
    Title: E2F1 Transcription Factor Regulates O-linked N-acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Expression.
  10. Conditional disruption of the O-GlcNAcase in mice leads to metabolic deregulation and semi-penetrant perinatal lethality.
    Title: Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • mKIAA0679, 2810009A20Rik, 4833427O07Rik, 5830447M11Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-N-acetylglucosaminidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-N-acetylglucosaminidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hexosaminidase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-acetylglucosamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in N-acetylglucosamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dATP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cardiac muscle adaptation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of D-glucose import ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell killing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of growth hormone secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein-containing complex disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deglycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deglycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein O-GlcNAcase
Names
N-acetyl-beta-D-glucosaminidase
N-acetyl-beta-glucosaminidase
beta-N-acetylhexosaminidase
beta-hexosaminidase
bifunctional protein NCOAT
meningioma expressed antigen 5 (hyaluronidase)
meningioma-expressed antigen 5
nuclear cytoplasmic O-GlcNAcase and acetyltransferase
NP_001390278.1
NP_001390280.1
NP_001390281.1
NP_001390282.1
NP_076288.1
XP_017173794.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403349.1 → NP_001390278.1  protein O-GlcNAcase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC149086

  2. NM_001403351.1 → NP_001390280.1  protein O-GlcNAcase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC149086

  3. NM_001403352.1 → NP_001390281.1  protein O-GlcNAcase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC149086

  4. NM_001403353.1 → NP_001390282.1  protein O-GlcNAcase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC149086

  5. NM_023799.5 → NP_076288.1  protein O-GlcNAcase isoform 1

    See identical proteins and their annotated locations for NP_076288.1

    Status: VALIDATED

    Source sequence(s)
    AC149086
    Consensus CDS
    CCDS29866.1
    UniProtKB/Swiss-Prot
    Q3ULY7, Q6ZQ71, Q8BK05, Q8BTT2, Q8CFX2, Q9CSJ4, Q9CUR7, Q9EQQ9
    Related
    ENSMUSP00000026243.4, ENSMUST00000026243.5
    Conserved Domains (1) summary
    pfam07555
    Location:62 → 338
    NAGidase; beta-N-acetylglucosaminidase

RNA

  1. NR_151594.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149086

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    45738698..45772274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318305.3 → XP_017173794.2  protein O-GlcNAcase isoform X2

    UniProtKB/TrEMBL
    Q05CX1
    Conserved Domains (1) summary
    pfam07555
    Location:100 → 376
    NAGidase; beta-N-acetylglucosaminidase

RNA

  1. XR_004940181.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQQ9.2 GenPept UniProtKB/Swiss-Prot:Q9EQQ9

Gene LinkOut

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