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Lpo lactoperoxidase [ Mus musculus (house mouse) ]

Gene ID: 76113, updated on 28-Oct-2024

Summary

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Official Symbol
Lpoprovided by MGI
Official Full Name
lactoperoxidaseprovided by MGI
Primary source
MGI:MGI:1923363
See related
Ensembl:ENSMUSG00000009356 AllianceGenome:MGI:1923363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5830499B15Rik
Summary
Enables peroxidase activity. Predicted to be involved in defense response to bacterium and detection of chemical stimulus involved in sensory perception of bitter taste. Located in cytoplasm. Is expressed in parotid gland and submandibular gland. Orthologous to human LPO (lactoperoxidase). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Restricted expression toward colon adult (RPKM 60.4) See more
Orthologs
human all
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Genomic context

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See Lpo in Genome Data Viewer
Location:
11 C; 11 52.22 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87697254..87716750, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87806428..87826114, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene TSPO associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7040 Neighboring gene Mpo distal enhancer region Neighboring gene Mpo proximal enhancer and promoter region Neighboring gene myeloperoxidase Neighboring gene STARR-seq mESC enhancer starr_30300 Neighboring gene MKS transition zone complex subunit 1 Neighboring gene eosinophil peroxidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice. Yamakaze J, et al. Sci Rep, 2021 Jun 14. PMID 34127712, Free PMC Article
  2. The mechanism and significance of the conversion of xanthine dehydrogenase to xanthine oxidase in mammalian secretory gland cells. Kusano T, et al. Redox Biol, 2023 Feb. PMID 36525890, Free PMC Article
  3. The potential for repositioning antithyroid agents as antiasthma drugs. Suzuki S, et al. J Allergy Clin Immunol, 2016 Nov. PMID 27444178
  4. Expression of lactoperoxidase in differentiated mouse colon epithelial cells. Kim BW, et al. Free Radic Biol Med, 2012 May 1. PMID 22343415, Free PMC Article
  5. The evolutionary conservation of the mammalian peroxidase genes. Sakamaki K, et al. Cytogenet Genome Res, 2002. PMID 12584448

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice.
    Title: Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice.
  2. we postulate that Lpo upregulation in the intestinal epithelium of miR-10a deficient mice together with the predominant abundance of estrogens in female animals mainly accounts for the sex-related cancer phenotype we observed
    Title: Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice.
  3. methylation of the Lpo intragenic CpG island was not directly induced by inflammation, because dextran sulfate sodium-induced colitis did not increase DNA methylation in B6 DKO colon. Also, Lpo DNA methylation is not correlated with gene expression
    Title: Expression of lactoperoxidase in differentiated mouse colon epithelial cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables lactoperoxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thiocyanate peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiocyanate peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables thiocyanate peroxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in detection of chemical stimulus involved in sensory perception of bitter taste IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of bitter taste ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in thiocyanate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lactoperoxidase
NP_536345.2
XP_011247600.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080420.3 → NP_536345.2  lactoperoxidase precursor

    See identical proteins and their annotated locations for NP_536345.2

    Status: VALIDATED

    Source sequence(s)
    AL604022, AL606805
    Consensus CDS
    CCDS25218.1
    UniProtKB/Swiss-Prot
    Q5SW46
    UniProtKB/TrEMBL
    Q91WA0
    Related
    ENSMUSP00000099466.4, ENSMUST00000103177.10
    Conserved Domains (1) summary
    cd09824
    Location:281 → 692
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    87697254..87716750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249298.4 → XP_011247600.1  lactoperoxidase isoform X1

    See identical proteins and their annotated locations for XP_011247600.1

    UniProtKB/Swiss-Prot
    Q5SW46
    UniProtKB/TrEMBL
    Q91WA0
    Conserved Domains (1) summary
    cd09824
    Location:281 → 692
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SW46.1 GenPept UniProtKB/Swiss-Prot:Q5SW46

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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