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Slc35d3 solute carrier family 35, member D3 [ Mus musculus (house mouse) ]

Gene ID: 76157, updated on 2-Nov-2024

Summary

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Official Symbol
Slc35d3provided by MGI
Official Full Name
solute carrier family 35, member D3provided by MGI
Primary source
MGI:MGI:1923407
See related
Ensembl:ENSMUSG00000050473 AllianceGenome:MGI:1923407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Frcl1; 6230421J19Rik
Summary
Enables UDP-glucose transmembrane transporter activity and protein-macromolecule adaptor activity. Involved in UDP-glucose transmembrane transport; platelet dense granule organization; and positive regulation of autophagy. Acts upstream of or within energy homeostasis and positive regulation of protein exit from endoplasmic reticulum. Located in early endosome and endoplasmic reticulum. Is active in early endosome membrane. Is expressed in midbrain mantle layer and thymus primordium. Orthologous to human SLC35D3 (solute carrier family 35 member D3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in adrenal adult (RPKM 13.5), frontal lobe adult (RPKM 1.5) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Slc35d3 in Genome Data Viewer
Location:
10 A3; 10 9.12 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (19723662..19728195, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (19847917..19856634, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33332 Neighboring gene interleukin 20 receptor, alpha Neighboring gene predicted gene, 25256 Neighboring gene STARR-seq mESC enhancer starr_25941 Neighboring gene STARR-seq mESC enhancer starr_25942 Neighboring gene STARR-seq mESC enhancer starr_25943 Neighboring gene peroxisomal biogenesis factor 7 Neighboring gene STARR-positive B cell enhancer ABC_E10597 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19659120-19659310 Neighboring gene mitogen-activated protein kinase kinase kinase 5 Neighboring gene STARR-seq mESC enhancer starr_25945 Neighboring gene STARR-positive B cell enhancer mm9_chr10:19711687-19711987 Neighboring gene STARR-positive B cell enhancer ABC_E8326 Neighboring gene STARR-positive B cell enhancer ABC_E11432 Neighboring gene STARR-seq mESC enhancer starr_25946 Neighboring gene STARR-seq mESC enhancer starr_25947

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SLC35D3 promotes white adipose tissue browning to ameliorate obesity by NOTCH signaling. Wang H, et al. Nat Commun, 2023 Nov 23. PMID 37996411, Free PMC Article
  2. SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation. Wei ZB, et al. Autophagy, 2016 Jul 2. PMID 27171858, Free PMC Article
  3. Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose. Qian C, et al. Elife, 2021 Jul 16. PMID 34269178, Free PMC Article
  4. The Slc35d3 gene, encoding an orphan nucleotide sugar transporter, regulates platelet-dense granules. Chintala S, et al. Blood, 2007 Feb 15. PMID 17062724, Free PMC Article
  5. SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models. Meng R, et al. Blood, 2012 Jul 12. PMID 22611153, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC35D3 promotes white adipose tissue browning to ameliorate obesity by NOTCH signaling.
    Title: SLC35D3 promotes white adipose tissue browning to ameliorate obesity by NOTCH signaling.
  2. that SLC35D3 enhanced the formation of the BECN1-ATG14-PIK3C3 complex to induce autophagy
    Title: SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation.
  3. SLC35D3 is depleted in platelets from 2 of 3 Hermansky-Pudlak syndrome models and, when expressed ectopically in melanocytes, SLC35D3 localizes to melanosomes in a manner requiring a HPS-associated protein complex
    Title: SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models.
  4. Slc35d3 specifically regulates the contents of platelet-dense granules. Unlike HPS or CHS genes, it has no apparent effect on other lysosome-related organelles such as melanosomes or lysosomes
    Title: The Slc35d3 gene, encoding an orphan nucleotide sugar transporter, regulates platelet-dense granules.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-glucose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in UDP-glucose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UDP-glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within energy homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in platelet dense granule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein exit from endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of protein exit from endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in early endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
solute carrier family 35 member D3
Names
frc, fringe-like 1
fringe connection-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029529.3 → NP_083805.1  solute carrier family 35 member D3

    See identical proteins and their annotated locations for NP_083805.1

    Status: VALIDATED

    Source sequence(s)
    AC171277
    Consensus CDS
    CCDS23719.1
    UniProtKB/Swiss-Prot
    Q8BGF8, Q9CXD4
    UniProtKB/TrEMBL
    B9EI54
    Related
    ENSMUSP00000060589.5, ENSMUST00000059805.6
    Conserved Domains (1) summary
    COG5070
    Location:30 → 308
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    19723662..19728195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512916.5 → XP_006512979.1  solute carrier family 35 member D3 isoform X1

    Conserved Domains (1) summary
    pfam08449
    Location:19 → 152
    UAA; UAA transporter family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGF8.1 GenPept UniProtKB/Swiss-Prot:Q8BGF8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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