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Lamp5 lysosomal-associated membrane protein family, member 5 [ Mus musculus (house mouse) ]

Gene ID: 76161, updated on 28-Oct-2024

Summary

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Official Symbol
Lamp5provided by MGI
Official Full Name
lysosomal-associated membrane protein family, member 5provided by MGI
Primary source
MGI:MGI:1923411
See related
Ensembl:ENSMUSG00000027270 AllianceGenome:MGI:1923411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LAMP-5; BAD-LAMP; 3110035N03Rik; 6330527O06Rik
Summary
Involved in presynaptic modulation of chemical synaptic transmission. Located in several cellular components, including dendrite membrane; endosome; and growth cone membrane. Is active in GABA-ergic synapse and synaptic vesicle. Is expressed in several structures, including alimentary system; central nervous system; sensory organ; vertebral axis musculature; and vibrissa. Orthologous to human LAMP5 (lysosomal associated membrane protein family member 5). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in cortex adult (RPKM 56.6), frontal lobe adult (RPKM 36.0) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Lamp5 in Genome Data Viewer
Location:
2 F3; 2 67.26 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (135893945..135911837)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (136052025..136069917)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phospholipase C, beta 4 Neighboring gene STARR-seq mESC enhancer starr_05795 Neighboring gene predicted gene, 54133 Neighboring gene predicted gene, 26227 Neighboring gene STARR-seq mESC enhancer starr_05797 Neighboring gene p21 (RAC1) activated kinase 5 Neighboring gene predicted gene 14218 Neighboring gene predicted gene, 39942

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LAMP5 in presynaptic inhibitory terminals in the hindbrain and spinal cord: a role in startle response and auditory processing. Koebis M, et al. Mol Brain, 2019 Mar 12. PMID 30867010, Free PMC Article
  2. LAMP5 Fine-Tunes GABAergic Synaptic Transmission in Defined Circuits of the Mouse Brain. Tiveron MC, et al. PLoS One, 2016. PMID 27272053, Free PMC Article
  3. Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease. Deng Y, et al. Acta Neuropathol, 2022 Oct. PMID 35780436, Free PMC Article
  4. BAD-LAMP defines a subset of early endocytic organelles in subpopulations of cortical projection neurons. David A, et al. J Cell Sci, 2007 Jan 15. PMID 17215451
  5. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. Kizuka Y, et al. EMBO Mol Med, 2015 Feb. PMID 25592972, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease.
    Title: Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease.
  2. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord.
    Title: LAMP5 in presynaptic inhibitory terminals in the hindbrain and spinal cord: a role in startle response and auditory processing.
  3. Results show that in mice LAMP5 protein is specifically expressed in subpopulations of GABAergic neurons where it localizes at synaptic terminals, overlapping with VGAT and provide evidence for a fine-tuning function of LAMP5 in evoked GABAergic synaptic transmission.
    Title: LAMP5 Fine-Tunes GABAergic Synaptic Transmission in Defined Circuits of the Mouse Brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in establishment of protein localization to organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in growth cone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysosome-associated membrane glycoprotein 5
Names
LAMP family protein C20orf103 homolog
Protein C20orf103
brain and dendritic cell-associated LAMP
brain-associated LAMP-like protein
lysosome-associated membrane protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356548.1 → NP_001343477.1  lysosome-associated membrane glycoprotein 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL845354, AL928798
    Consensus CDS
    CCDS16789.1
    UniProtKB/Swiss-Prot
    Q9CXQ4, Q9D387
    Conserved Domains (1) summary
    pfam01299
    Location:43 → 213
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)

  2. NM_029530.3 → NP_083806.2  lysosome-associated membrane glycoprotein 5 precursor

    See identical proteins and their annotated locations for NP_083806.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL845354, AL928798
    Consensus CDS
    CCDS16789.1
    UniProtKB/Swiss-Prot
    Q9CXQ4, Q9D387
    Related
    ENSMUSP00000061180.7, ENSMUST00000057503.7
    Conserved Domains (1) summary
    pfam01299
    Location:43 → 213
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    135893945..135911837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319318.2 → XP_017174807.1  lysosome-associated membrane glycoprotein 5 isoform X2

    UniProtKB/Swiss-Prot
    Q9D387
    Conserved Domains (1) summary
    pfam01299
    Location:24 → 95
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)

  2. XM_036162664.1 → XP_036018557.1  lysosome-associated membrane glycoprotein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9CXQ4, Q9D387
    Conserved Domains (1) summary
    pfam01299
    Location:43 → 213
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)

RNA

  1. XR_004940765.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D387.2 GenPept UniProtKB/Swiss-Prot:Q9D387

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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