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ZNF76 zinc finger protein 76 [ Homo sapiens (human) ]

Gene ID: 7629, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF76provided by HGNC
Official Full Name
zinc finger protein 76provided by HGNC
Primary source
HGNC:HGNC:13149
See related
Ensembl:ENSG00000065029 MIM:194549; AllianceGenome:HGNC:13149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF523; Zfp523; D6S229E
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 13.0), testis (RPKM 11.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6p21.31
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (35259533..35295985)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (35082556..35119066)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35227512..35263762)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17084 Neighboring gene SCUBE3 antisense RNA 1 Neighboring gene signal peptide, CUB domain and EGF like domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 1078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17085 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:35211069-35212268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24396 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17087 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:35253595-35254794 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:35263932-35264096 Neighboring gene Sharpr-MPRA regulatory region 9100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35280323-35280822 Neighboring gene DEF6 guanine nucleotide exchange factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24399 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35328305-35329201 Neighboring gene peroxisome proliferator activated receptor delta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24402 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35351066-35351668 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35359676-35360244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35378432-35378965 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35378966-35379498

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF76 predicts prognosis and response to platinum chemotherapy in human ovarian cancer. Hua T, et al. Biosci Rep, 2021 Dec 22. PMID 34793589, Free PMC Article
  2. The ZNF76 rs10947540 polymorphism associated with systemic lupus erythematosus risk in Chinese populations. Qi YY, et al. Sci Rep, 2021 Mar 4. PMID 33664275, Free PMC Article
  3. ZNF76 and ZNF143 are two human homologs of the transcriptional activator Staf. Myslinski E, et al. J Biol Chem, 1998 Aug 21. PMID 9705341
  4. A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11. Ragoussis J, et al. Genomics, 1992 Nov. PMID 1427894
  5. Acetylation and alternative splicing regulate ZNF76-mediated transcription. Zheng G, et al. Biochem Biophys Res Commun, 2006 Jan 27. PMID 16337145

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF76 predicts prognosis and response to platinum chemotherapy in human ovarian cancer.
    Title: ZNF76 predicts prognosis and response to platinum chemotherapy in human ovarian cancer.
  2. The ZNF76 rs10947540 polymorphism associated with systemic lupus erythematosus risk in Chinese populations.
    Title: The ZNF76 rs10947540 polymorphism associated with systemic lupus erythematosus risk in Chinese populations.
  3. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
  5. ZNF76 functions as a transcriptional repressor through its interaction with TBP and sumoylation modulates its transcriptional repression activity
    Title: ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation.
  6. Our study shows that ZNF76, a TBP-interacting transcriptional modulator, is regulated by both lysine modifications and alternative splicing.
    Title: Acetylation and alternative splicing regulate ZNF76-mediated transcription.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase III TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 76
Names
zinc finger protein 523
zinc finger protein 76 (expressed in testis)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001292032.2 → NP_001278961.1  zinc finger protein 76 isoform 2

    See identical proteins and their annotated locations for NP_001278961.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BE962441, DC299240, M91592, Z97832
    Consensus CDS
    CCDS75435.1
    Related
    ENSP00000344097.5, ENST00000339411.5
    Conserved Domains (4) summary
    COG5048
    Location:192 → 250
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:167 → 189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:212 → 238
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:225 → 346
    zf-C2H2_aberr; Aberrant zinc-finger

  2. NM_003427.5 → NP_003418.2  zinc finger protein 76 isoform 1

    See identical proteins and their annotated locations for NP_003418.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC002549, BE962441, DC299240, Z97832
    Consensus CDS
    CCDS4801.1
    UniProtKB/Swiss-Prot
    P36508, Q9BQB2
    Related
    ENSP00000363064.3, ENST00000373953.8
    Conserved Domains (4) summary
    COG5048
    Location:179 → 366
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:106 → 220
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:167 → 189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl28087
    Location:279 → 483
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    35259533..35295985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011249.3 → XP_016866738.1  zinc finger protein 76 isoform X2

    UniProtKB/Swiss-Prot
    P36508, Q9BQB2
    Conserved Domains (4) summary
    COG5048
    Location:179 → 366
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:106 → 220
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:167 → 189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl28087
    Location:279 → 483
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  2. XM_017011256.2 → XP_016866745.1  zinc finger protein 76 isoform X9

    Conserved Domains (4) summary
    COG5048
    Location:192 → 250
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:167 → 189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:212 → 238
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:225 → 346
    zf-C2H2_aberr; Aberrant zinc-finger

  3. XM_047419300.1 → XP_047275256.1  zinc finger protein 76 isoform X1

  4. XM_047419305.1 → XP_047275261.1  zinc finger protein 76 isoform X6

  5. XM_047419307.1 → XP_047275263.1  zinc finger protein 76 isoform X11

    Related
    ENSP00000419106.1, ENST00000469195.5

  6. XM_047419302.1 → XP_047275258.1  zinc finger protein 76 isoform X4

  7. XM_047419299.1 → XP_047275255.1  zinc finger protein 76 isoform X1

  8. XM_047419304.1 → XP_047275260.1  zinc finger protein 76 isoform X6

  9. XM_047419301.1 → XP_047275257.1  zinc finger protein 76 isoform X3

  10. XM_047419306.1 → XP_047275262.1  zinc finger protein 76 isoform X10

  11. XM_017011255.2 → XP_016866744.1  zinc finger protein 76 isoform X8

  12. XM_047419303.1 → XP_047275259.1  zinc finger protein 76 isoform X5

  13. XM_011514856.4 → XP_011513158.1  zinc finger protein 76 isoform X7

    Conserved Domains (4) summary
    COG5048
    Location:132 → 190
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:107 → 129
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:152 → 178
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:165 → 286
    zf-C2H2_aberr; Aberrant zinc-finger

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    35082556..35119066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356318.1 → XP_054212293.1  zinc finger protein 76 isoform X2

    UniProtKB/Swiss-Prot
    P36508, Q9BQB2

  2. XM_054356326.1 → XP_054212301.1  zinc finger protein 76 isoform X9

  3. XM_054356317.1 → XP_054212292.1  zinc finger protein 76 isoform X1

  4. XM_054356323.1 → XP_054212298.1  zinc finger protein 76 isoform X6

  5. XM_054356328.1 → XP_054212303.1  zinc finger protein 76 isoform X11

  6. XM_054356320.1 → XP_054212295.1  zinc finger protein 76 isoform X4

  7. XM_054356316.1 → XP_054212291.1  zinc finger protein 76 isoform X1

  8. XM_054356322.1 → XP_054212297.1  zinc finger protein 76 isoform X6

  9. XM_054356319.1 → XP_054212294.1  zinc finger protein 76 isoform X3

  10. XM_054356327.1 → XP_054212302.1  zinc finger protein 76 isoform X10

  11. XM_054356325.1 → XP_054212300.1  zinc finger protein 76 isoform X8

  12. XM_054356321.1 → XP_054212296.1  zinc finger protein 76 isoform X5

  13. XM_054356324.1 → XP_054212299.1  zinc finger protein 76 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36508.2 GenPept UniProtKB/Swiss-Prot:P36508

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