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Mtif3 mitochondrial translational initiation factor 3 [ Mus musculus (house mouse) ]

Gene ID: 76366, updated on 28-Oct-2024

Summary

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Official Symbol
Mtif3provided by MGI
Official Full Name
mitochondrial translational initiation factor 3provided by MGI
Primary source
MGI:MGI:1923616
See related
Ensembl:ENSMUSG00000016510 AllianceGenome:MGI:1923616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810012L14Rik
Summary
Predicted to enable ribosomal small subunit binding activity and translation initiation factor activity. Predicted to be involved in mitochondrial translational initiation and ribosome disassembly. Predicted to be active in mitochondrion. Used to study dilated cardiomyopathy. Orthologous to human MTIF3 (mitochondrial translational initiation factor 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 7.4), CNS E18 (RPKM 6.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mtif3 in Genome Data Viewer
Location:
5 G3; 5 86.57 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (146888383..146900665, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (146951573..146963855, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38748 Neighboring gene STARR-seq mESC enhancer starr_14856 Neighboring gene STARR-seq mESC enhancer starr_14857 Neighboring gene STARR-positive B cell enhancer mm9_chr5:147716001-147716302 Neighboring gene predicted gene 10858 Neighboring gene STARR-seq mESC enhancer starr_14858 Neighboring gene STARR-seq mESC enhancer starr_14860 Neighboring gene STARR-positive B cell enhancer ABC_E9268 Neighboring gene STARR-positive B cell enhancer ABC_E10366 Neighboring gene STARR-seq mESC enhancer starr_14863 Neighboring gene general transcription factor III A Neighboring gene STARR-seq mESC enhancer starr_14864 Neighboring gene predicted gene, 46936 Neighboring gene ligand of numb-protein X 2 Neighboring gene STARR-positive B cell enhancer ABC_E6405 Neighboring gene STARR-positive B cell enhancer ABC_E6406 Neighboring gene STARR-seq mESC enhancer starr_14866 Neighboring gene STARR-positive B cell enhancer ABC_E2184

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fidelity of translation initiation is required for coordinated respiratory complex assembly. Rudler DL, et al. Sci Adv, 2019 Dec. PMID 31903419, Free PMC Article
  2. Mitochondrial gene expression is required for platelet function and blood clotting. Richman TR, et al. Cell Rep, 2023 Nov 28. PMID 37889747
  3. Identification of mammalian mitochondrial translational initiation factor 3 and examination of its role in initiation complex formation with natural mRNAs. Koc EC, et al. J Biol Chem, 2002 Sep 20. PMID 12095986
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ribosomal small subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal small subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation factor activity, RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables translation factor activity, RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in ribosome disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
translation initiation factor IF-3, mitochondrial
Names
IF-3(Mt)
IF-3Mt
IF3(mt)
IF3mt

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256100.1 → NP_001243029.1  translation initiation factor IF-3, mitochondrial

    See identical proteins and their annotated locations for NP_001243029.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AK012733, BC052439, BC115685, BM944410, BY284518
    Consensus CDS
    CCDS19874.1
    UniProtKB/Swiss-Prot
    Q14BP1, Q14BP2, Q9CZD5
    UniProtKB/TrEMBL
    A4QMQ0
    Related
    ENSMUSP00000106193.2, ENSMUST00000110564.8
    Conserved Domains (2) summary
    pfam05198
    Location:76 → 143
    IF3_N; Translation initiation factor IF-3, N-terminal domain
    cl27649
    Location:62 → 225
    IF3_C; Translation initiation factor IF-3, C-terminal domain

  2. NM_001256101.1 → NP_001243030.1  translation initiation factor IF-3, mitochondrial

    See identical proteins and their annotated locations for NP_001243030.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AK012733, BC052439, BM944410, BY284518
    Consensus CDS
    CCDS19874.1
    UniProtKB/Swiss-Prot
    Q14BP1, Q14BP2, Q9CZD5
    UniProtKB/TrEMBL
    A4QMQ0
    Related
    ENSMUSP00000016654.3, ENSMUST00000016654.9
    Conserved Domains (2) summary
    pfam05198
    Location:76 → 143
    IF3_N; Translation initiation factor IF-3, N-terminal domain
    cl27649
    Location:62 → 225
    IF3_C; Translation initiation factor IF-3, C-terminal domain

  3. NM_001256102.1 → NP_001243031.1  translation initiation factor IF-3, mitochondrial

    See identical proteins and their annotated locations for NP_001243031.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    BC052439, BC115684, BC115685, BM944410, BY284518
    Consensus CDS
    CCDS19874.1
    UniProtKB/Swiss-Prot
    Q14BP1, Q14BP2, Q9CZD5
    UniProtKB/TrEMBL
    A4QMQ0
    Related
    ENSMUSP00000106195.2, ENSMUST00000110566.2
    Conserved Domains (2) summary
    pfam05198
    Location:76 → 143
    IF3_N; Translation initiation factor IF-3, N-terminal domain
    cl27649
    Location:62 → 225
    IF3_C; Translation initiation factor IF-3, C-terminal domain

  4. NM_001359467.1 → NP_001346396.1  translation initiation factor IF-3, mitochondrial

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC124828, AL513345
    Consensus CDS
    CCDS19874.1
    UniProtKB/Swiss-Prot
    Q14BP1, Q14BP2, Q9CZD5
    UniProtKB/TrEMBL
    A4QMQ0
    Conserved Domains (2) summary
    pfam05198
    Location:76 → 143
    IF3_N; Translation initiation factor IF-3, N-terminal domain
    cl27649
    Location:62 → 225
    IF3_C; Translation initiation factor IF-3, C-terminal domain

  5. NM_029581.4 → NP_083857.1  translation initiation factor IF-3, mitochondrial

    See identical proteins and their annotated locations for NP_083857.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AK147090, BC052439, BM944410, BY284518
    Consensus CDS
    CCDS19874.1
    UniProtKB/Swiss-Prot
    Q14BP1, Q14BP2, Q9CZD5
    UniProtKB/TrEMBL
    A4QMQ0
    Related
    ENSMUSP00000063398.4, ENSMUST00000066675.10
    Conserved Domains (2) summary
    pfam05198
    Location:76 → 143
    IF3_N; Translation initiation factor IF-3, N-terminal domain
    cl27649
    Location:62 → 225
    IF3_C; Translation initiation factor IF-3, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    146888383..146900665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZD5.1 GenPept UniProtKB/Swiss-Prot:Q9CZD5

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