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Daam2 dishevelled associated activator of morphogenesis 2 [ Mus musculus (house mouse) ]

Gene ID: 76441, updated on 28-Oct-2024

Summary

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Official Symbol
Daam2provided by MGI
Official Full Name
dishevelled associated activator of morphogenesis 2provided by MGI
Primary source
MGI:MGI:1923691
See related
Ensembl:ENSMUSG00000040260 AllianceGenome:MGI:1923691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310016D11Rik
Summary
Predicted to enable actin binding activity and small GTPase binding activity. Involved in dorsal spinal cord development; negative regulation of oligodendrocyte differentiation; and regulation of Wnt signaling pathway. Acts upstream of or within determination of left/right symmetry. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and limb. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to human DAAM2 (dishevelled associated activator of morphogenesis 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in cerebellum adult (RPKM 13.0), testis adult (RPKM 12.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Daam2 in Genome Data Viewer
Location:
17 C; 17 25.5 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (49763050..49871517, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (49456022..49564459, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41594 Neighboring gene STARR-positive B cell enhancer ABC_E1944 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:49568292-49568475 Neighboring gene molybdenum cofactor synthesis 1 Neighboring gene predicted gene, 52301 Neighboring gene kinesin family member 6 Neighboring gene VISTA enhancer mm276 Neighboring gene STARR-seq mESC enhancer starr_42779 Neighboring gene STARR-seq mESC enhancer starr_42780 Neighboring gene STARR-seq mESC enhancer starr_42781 Neighboring gene STARR-seq mESC enhancer starr_42782 Neighboring gene predicted gene 16555 Neighboring gene STARR-seq mESC enhancer starr_42783 Neighboring gene STARR-seq mESC enhancer starr_42784 Neighboring gene STARR-seq mESC enhancer starr_42785 Neighboring gene predicted gene, 19465

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Daam2 phosphorylation by CK2α negatively regulates Wnt activity during white matter development and injury. Wang CY, et al. Proc Natl Acad Sci U S A, 2023 Aug 29. PMID 37607236, Free PMC Article
  2. Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2. Colozza G, et al. Sci Adv, 2023 Nov 24. PMID 38000028, Free PMC Article
  3. Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin Cytoskeleton through Rac1 and Gelsolin. Cristobal CD, et al. J Neurosci, 2022 Mar 2. PMID 35101966, Free PMC Article
  4. Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function. Jo J, et al. EMBO Rep, 2021 Dec 6. PMID 34633730, Free PMC Article
  5. The Daam2-VHL-Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation. Ding X, et al. Genes Dev, 2020 Sep 1. PMID 32792353, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin Cytoskeleton through Rac1 and Gelsolin.
    Title: Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin Cytoskeleton through Rac1 and Gelsolin.
  2. we generated Daam-deficient mice by gene targeting and found that Daam1, but not Daam2, is necessary for fetal survival. Embryonic development of Daam1 mutants was delayed most likely due to functional defects in the labyrinthine layer of the placenta. Examination of Daam2 and Daam1/2 double mutants revealed that Daam1 and Daam2 are functionally redundant during placental development.
    Title: Placental defects lead to embryonic lethality in mice lacking the Formin and PCP proteins Daam1 and Daam2.
  3. Daam1 knockout mice that were also homozygous for Daam2 had stronger noncompaction cardiomyopathy, severely reduced cardiac function, disrupted sarcomere structure, and increased myocardial proliferation.
    Title: DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly.
  4. a pharmacological strategy to inhibit Daam2-PIP5K function, application of which stimulates remyelination after white matter injury
    Title: Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS.
  5. involved in pivotal steps in neuronal cell differentiation and movement
    Title: Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system.
  6. Daams are expressed in tissues known to require Wnts, so effectors of Wnt signaling during vertebrate development.
    Title: Identification and comparative expression analyses of Daam genes in mouse and Xenopus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal spinal cord development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of oligodendrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of oligodendrocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in podocyte cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in podocyte cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of filopodium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of non-canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
disheveled-associated activator of morphogenesis 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008231.2 → NP_001008232.2  disheveled-associated activator of morphogenesis 2 isoform 1

    See identical proteins and their annotated locations for NP_001008232.2

    Status: VALIDATED

    Source sequence(s)
    AC165258, AK009382, AY426536, BC050043
    Consensus CDS
    CCDS37648.1
    UniProtKB/Swiss-Prot
    E9QNU9, Q6TAB7, Q80U19, Q810J5
    Related
    ENSMUSP00000052085.7, ENSMUST00000057610.8
    Conserved Domains (3) summary
    pfam02181
    Location:595 → 1016
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  2. NM_001379371.1 → NP_001366300.1  disheveled-associated activator of morphogenesis 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124748, AC165258
    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:595 → 996
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  3. NM_001379372.1 → NP_001366301.1  disheveled-associated activator of morphogenesis 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124748, AC165258
    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:595 → 968
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    49763050..49871517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525090.5 → XP_006525153.1  disheveled-associated activator of morphogenesis 2 isoform X2

    Conserved Domains (3) summary
    pfam02181
    Location:587 → 988
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  2. XM_006525083.5 → XP_006525146.1  disheveled-associated activator of morphogenesis 2 isoform X1

    See identical proteins and their annotated locations for XP_006525146.1

    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:595 → 996
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  3. XM_036160827.1 → XP_036016720.1  disheveled-associated activator of morphogenesis 2 isoform X4

    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:587 → 960
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  4. XM_006525089.5 → XP_006525152.1  disheveled-associated activator of morphogenesis 2 isoform X1

    See identical proteins and their annotated locations for XP_006525152.1

    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:595 → 996
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  5. XM_036160826.1 → XP_036016719.1  disheveled-associated activator of morphogenesis 2 isoform X3

    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:595 → 968
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  6. XM_006525084.5 → XP_006525147.1  disheveled-associated activator of morphogenesis 2 isoform X1

    See identical proteins and their annotated locations for XP_006525147.1

    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:595 → 996
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  7. XM_006525085.5 → XP_006525148.1  disheveled-associated activator of morphogenesis 2 isoform X1

    See identical proteins and their annotated locations for XP_006525148.1

    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:595 → 996
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  8. XM_006525086.4 → XP_006525149.1  disheveled-associated activator of morphogenesis 2 isoform X1

    See identical proteins and their annotated locations for XP_006525149.1

    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:595 → 996
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  9. XM_036160828.1 → XP_036016721.1  disheveled-associated activator of morphogenesis 2 isoform X5

    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain
    cl19758
    Location:595 → 651
    FH2; Formin Homology 2 Domain

RNA

  1. XR_004939600.1 RNA Sequence

  2. XR_004939598.1 RNA Sequence

  3. XR_004939599.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80U19.4 GenPept UniProtKB/Swiss-Prot:Q80U19

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