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Rmc1 regulator of MON1-CCZ1 [ Mus musculus (house mouse) ]

Gene ID: 76482, updated on 2-Nov-2024

Summary

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Official Symbol
Rmc1provided by MGI
Official Full Name
regulator of MON1-CCZ1provided by MGI
Primary source
MGI:MGI:1916528
See related
Ensembl:ENSMUSG00000024410 AllianceGenome:MGI:1916528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mic1; Mic-1; Wdr98; 2400010D15Rik; 3110002H16Rik
Summary
Predicted to be involved in regulation of autophagy. Predicted to be located in lysosomal membrane. Predicted to be part of Mon1-Ccz1 complex. Predicted to be active in late endosome membrane. Is expressed in several structures, including adrenal gland; genitourinary system; liver; lung; and spleen. Orthologous to human RMC1 (regulator of MON1-CCZ1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14.5 (RPKM 20.0), liver E14 (RPKM 18.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rmc1 in Genome Data Viewer
Location:
18 A1; 18 6.15 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (12301746..12331732)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (12168689..12198675)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4239 Neighboring gene STARR-positive B cell enhancer ABC_E3223 Neighboring gene RIO kinase 3 Neighboring gene predicted gene, 25289 Neighboring gene predicted gene, 19293 Neighboring gene STARR-positive B cell enhancer ABC_E2504 Neighboring gene STARR-seq mESC enhancer starr_43833 Neighboring gene NPC intracellular cholesterol transporter 1 Neighboring gene ankyrin repeat domain 29 Neighboring gene ecotropic viral integration site 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43835 Neighboring gene laminin, alpha 3 Neighboring gene predicted gene, 36232

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene. Loftus SK, et al. Science, 1997 Jul 11. PMID 9211850
  2. Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay. Darakhshan F, et al. Carcinogenesis, 2006 Feb. PMID 16093251
  3. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • AC102096.3

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Mon1-Ccz1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Mon1-Ccz1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of Mon1-Ccz1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
regulator of MON1-CCZ1 complex
Names
colon cancer-associated protein Mic1 homolog
uncharacterized protein C18orf8 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029623.2 → NP_083899.1  regulator of MON1-CCZ1 complex

    See identical proteins and their annotated locations for NP_083899.1

    Status: VALIDATED

    Source sequence(s)
    AF003352, AK144623, AK159691
    Consensus CDS
    CCDS29063.1
    UniProtKB/Swiss-Prot
    O35606, Q8VC42
    UniProtKB/TrEMBL
    Q3U4H5, Q3UMX3
    Related
    ENSMUSP00000025276.9, ENSMUST00000025276.15
    Conserved Domains (1) summary
    pfam07035
    Location:475 → 631
    Mic1; Colon cancer-associated protein Mic1-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    12301746..12331732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526341.3 → XP_006526404.1  regulator of MON1-CCZ1 complex isoform X1

    UniProtKB/TrEMBL
    Q3UMX3
    Conserved Domains (1) summary
    pfam07035
    Location:475 → 632
    Mic1; Colon cancer-associated protein Mic1-like

  2. XM_006526342.5 → XP_006526405.1  regulator of MON1-CCZ1 complex isoform X2

    UniProtKB/TrEMBL
    Q3UMX3
    Conserved Domains (1) summary
    pfam07035
    Location:421 → 578
    Mic1; Colon cancer-associated protein Mic1-like

RNA

  1. XR_386019.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC42.1 GenPept UniProtKB/Swiss-Prot:Q8VC42

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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