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Atg2b autophagy related 2B [ Mus musculus (house mouse) ]

Gene ID: 76559, updated on 2-Nov-2024

Summary

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Official Symbol
Atg2bprovided by MGI
Official Full Name
autophagy related 2Bprovided by MGI
Primary source
MGI:MGI:1923809
See related
Ensembl:ENSMUSG00000041341 AllianceGenome:MGI:1923809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4067; 2410024A21Rik; C030004M05Rik; C630028L02Rik
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity and protein-membrane adaptor activity. Predicted to be involved in autophagy of mitochondrion and macroautophagy. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and phagophore assembly site membrane. Predicted to be active in phagophore and phagophore assembly site. Orthologous to human ATG2B (autophagy related 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 6.2), testis adult (RPKM 5.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Atg2b in Genome Data Viewer
Location:
12 E; 12 55.82 cM
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (105579798..105651554, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (105613539..105685297, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33182 Neighboring gene bradykinin receptor, beta 2 Neighboring gene STARR-positive B cell enhancer ABC_E4041 Neighboring gene bradykinin receptor, beta 1 Neighboring gene STARR-seq mESC enhancer starr_33186 Neighboring gene STARR-seq mESC enhancer starr_33187 Neighboring gene STARR-positive B cell enhancer ABC_E5352 Neighboring gene GSK3B interacting protein Neighboring gene adenylate kinase 7 Neighboring gene STARR-seq mESC enhancer starr_33192 Neighboring gene STARR-seq mESC enhancer starr_33193

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse satellite DNA is transcribed in senescent cardiac muscle. Gaubatz JW, et al. J Biol Chem, 1990 Oct 15. PMID 1698780
  2. Development and application of a recombination-based library versus library high- throughput yeast two-hybrid (RLL-Y2H) screening system. Yang F, et al. Nucleic Acids Res, 2018 Feb 16. PMID 29165646, Free PMC Article
  3. Loss of Atg2b and Gskip Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size. Sakai SS, et al. Mol Cell Biol, 2022 Jan 20. PMID 34748402, Free PMC Article
  4. Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans. Nicola AM, et al. Infect Immun, 2012 Sep. PMID 22710871, Free PMC Article
  5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4067

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in pexophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
is_active_in phagophore IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
autophagy-related protein 2 homolog B
Names
ATG2 autophagy related 2 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403515.1 → NP_001390444.1  autophagy-related protein 2 homolog B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068459, AC158526

  2. NM_029654.5 → NP_083930.5  autophagy-related protein 2 homolog B isoform 1

    See identical proteins and their annotated locations for NP_083930.5

    Status: VALIDATED

    Source sequence(s)
    AC068459, AC158526
    Consensus CDS
    CCDS36550.1
    UniProtKB/Swiss-Prot
    A0PJL7, Q80XK6, Q8BIQ4, Q8BIV0, Q8R1H5, Q9CWK6
    Related
    ENSMUSP00000037441.8, ENSMUST00000041055.9
    Conserved Domains (3) summary
    pfam09333
    Location:1977 → 2071
    ATG_C; Autophagy-related protein C terminal domain
    pfam12624
    Location:11 → 105
    Chorein_N; N-terminal region of Chorein or VPS13
    pfam13329
    Location:1239 → 1359
    ATG2_CAD; Autophagy-related protein 2 CAD motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    105579798..105651554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157656.1 → XP_036013549.1  autophagy-related protein 2 homolog B isoform X3

    UniProtKB/TrEMBL
    A0A1Y7VNP1
    Conserved Domains (1) summary
    pfam09333
    Location:916 → 1010
    ATG_C; Autophagy-related protein C terminal domain

  2. XM_006516361.3 → XP_006516424.1  autophagy-related protein 2 homolog B isoform X2

    UniProtKB/TrEMBL
    A0A1Y7VNP1
    Related
    ENSMUSP00000152527.2, ENSMUST00000221015.2
    Conserved Domains (1) summary
    pfam09333
    Location:917 → 1011
    ATG_C; Autophagy-related protein C terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XK6.3 GenPept UniProtKB/Swiss-Prot:Q80XK6

Gene LinkOut

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