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Lrrc27 leucine rich repeat containing 27 [ Mus musculus (house mouse) ]

Gene ID: 76612, updated on 2-Nov-2024

Summary

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Official Symbol
Lrrc27provided by MGI
Official Full Name
leucine rich repeat containing 27provided by MGI
Primary source
MGI:MGI:1923862
See related
Ensembl:ENSMUSG00000015980 AllianceGenome:MGI:1923862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700071K18Rik; 2310044E02Rik
Summary
Predicted to enable actin binding activity. Predicted to be involved in cardiac muscle cell development. Predicted to be active in cytoskeleton and sarcomere. Orthologous to human LRRC27 (leucine rich repeat containing 27). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 100.4) and subcutaneous fat pad adult (RPKM 2.5) See more
Orthologs
human all
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Genomic context

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See Lrrc27 in Genome Data Viewer
Location:
7 F4; 7 84.3 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (138791548..138822895)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139211632..139242979)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20414 Neighboring gene janus kinase and microtubule interacting protein 3 Neighboring gene dihydropyrimidinase-like 4 Neighboring gene serine/threonine kinase 32C Neighboring gene STARR-positive B cell enhancer ABC_E11373 Neighboring gene STARR-positive B cell enhancer ABC_E296 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:146410713-146410866 Neighboring gene predicted gene, 32315 Neighboring gene PWWP domain containing 2B Neighboring gene predicted gene, 32486 Neighboring gene predicted gene, 51504

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cardiac muscle cell development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sarcomere IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143755.1 → NP_001137227.1  leucine-rich repeat-containing protein 27 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has a distinct 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC093363, AI614174, AK006931, CO040070
    Consensus CDS
    CCDS52426.1
    UniProtKB/TrEMBL
    D3Z4R3
    Related
    ENSMUSP00000101710.2, ENSMUST00000106104.8
    Conserved Domains (3) summary
    sd00031
    Location:58 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:76 → 117
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:76 → 135
    LRR_8; Leucine rich repeat

  2. NM_027164.1 → NP_081440.1  leucine-rich repeat-containing protein 27 isoform a

    See identical proteins and their annotated locations for NP_081440.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC050816
    Consensus CDS
    CCDS21953.1
    UniProtKB/Swiss-Prot
    Q80YS5, Q9D6Z2
    Related
    ENSMUSP00000016124.9, ENSMUST00000016124.15
    Conserved Domains (2) summary
    sd00031
    Location:58 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:77 → 135
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    138791548..138822895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006536267.4 → XP_006536330.1  leucine-rich repeat-containing protein 27 isoform X3

    Conserved Domains (2) summary
    sd00031
    Location:3 → 23
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:3 → 57
    LRR_8; Leucine rich repeat

  2. XM_011249862.3 → XP_011248164.1  leucine-rich repeat-containing protein 27 isoform X1

    See identical proteins and their annotated locations for XP_011248164.1

    UniProtKB/Swiss-Prot
    Q80YS5, Q9D6Z2
    Conserved Domains (2) summary
    sd00031
    Location:58 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:77 → 135
    LRR_8; Leucine rich repeat

  3. XM_006536266.4 → XP_006536329.1  leucine-rich repeat-containing protein 27 isoform X2

    Conserved Domains (2) summary
    sd00031
    Location:58 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:77 → 135
    LRR_8; Leucine rich repeat

  4. XM_006536262.4 → XP_006536325.1  leucine-rich repeat-containing protein 27 isoform X1

    See identical proteins and their annotated locations for XP_006536325.1

    UniProtKB/Swiss-Prot
    Q80YS5, Q9D6Z2
    Conserved Domains (2) summary
    sd00031
    Location:58 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:77 → 135
    LRR_8; Leucine rich repeat

  5. XM_006536268.4 → XP_006536331.1  leucine-rich repeat-containing protein 27 isoform X4

    Conserved Domains (3) summary
    COG4886
    Location:54 → 252
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:58 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:76 → 135
    LRR_8; Leucine rich repeat

  6. XM_011249863.3 → XP_011248165.1  leucine-rich repeat-containing protein 27 isoform X1

    See identical proteins and their annotated locations for XP_011248165.1

    UniProtKB/Swiss-Prot
    Q80YS5, Q9D6Z2
    Conserved Domains (2) summary
    sd00031
    Location:58 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:77 → 135
    LRR_8; Leucine rich repeat

  7. XM_006536265.4 → XP_006536328.1  leucine-rich repeat-containing protein 27 isoform X1

    See identical proteins and their annotated locations for XP_006536328.1

    UniProtKB/Swiss-Prot
    Q80YS5, Q9D6Z2
    Conserved Domains (2) summary
    sd00031
    Location:58 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:77 → 135
    LRR_8; Leucine rich repeat

  8. XM_036153547.1 → XP_036009440.1  leucine-rich repeat-containing protein 27 isoform X4

    Conserved Domains (3) summary
    COG4886
    Location:54 → 252
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:58 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:76 → 135
    LRR_8; Leucine rich repeat

  9. XM_036153546.1 → XP_036009439.1  leucine-rich repeat-containing protein 27 isoform X3

    Conserved Domains (2) summary
    sd00031
    Location:3 → 23
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:3 → 57
    LRR_8; Leucine rich repeat

  10. XM_030243079.2 → XP_030098939.1  leucine-rich repeat-containing protein 27 isoform X2

    Conserved Domains (2) summary
    sd00031
    Location:58 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:77 → 135
    LRR_8; Leucine rich repeat

  11. XM_006536264.3 → XP_006536327.1  leucine-rich repeat-containing protein 27 isoform X1

    See identical proteins and their annotated locations for XP_006536327.1

    UniProtKB/Swiss-Prot
    Q80YS5, Q9D6Z2
    Conserved Domains (2) summary
    sd00031
    Location:58 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:77 → 135
    LRR_8; Leucine rich repeat

  12. XM_011249864.2 → XP_011248166.1  leucine-rich repeat-containing protein 27 isoform X1

    See identical proteins and their annotated locations for XP_011248166.1

    UniProtKB/Swiss-Prot
    Q80YS5, Q9D6Z2
    Conserved Domains (2) summary
    sd00031
    Location:58 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:77 → 135
    LRR_8; Leucine rich repeat

  13. XM_036153548.1 → XP_036009441.1  leucine-rich repeat-containing protein 27 isoform X4

    Conserved Domains (3) summary
    COG4886
    Location:54 → 252
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:58 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:76 → 135
    LRR_8; Leucine rich repeat

  14. XM_011249865.2 → XP_011248167.1  leucine-rich repeat-containing protein 27 isoform X1

    See identical proteins and their annotated locations for XP_011248167.1

    UniProtKB/Swiss-Prot
    Q80YS5, Q9D6Z2
    Conserved Domains (2) summary
    sd00031
    Location:58 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:77 → 135
    LRR_8; Leucine rich repeat

  15. XM_006536269.5 → XP_006536332.1  leucine-rich repeat-containing protein 27 isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YS5.1 GenPept UniProtKB/Swiss-Prot:Q80YS5

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