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Catsperg2 cation channel sperm associated auxiliary subunit gamma 2 [ Mus musculus (house mouse) ]

Gene ID: 76718, updated on 2-Nov-2024

Summary

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Official Symbol
Catsperg2provided by MGI
Official Full Name
cation channel sperm associated auxiliary subunit gamma 2provided by MGI
Primary source
MGI:MGI:1923968
See related
Ensembl:ENSMUSG00000049123 AllianceGenome:MGI:1923968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CATSPERG; 1700067C01Rik
Summary
Predicted to be involved in cell differentiation and spermatogenesis. Located in motile cilium. Part of CatSper complex. Is expressed in germ cell of testis; seminiferous tubule; spermatid; spermatocyte; and testis. Orthologous to human CATSPERG (cation channel sperm associated auxiliary subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 75.6) See more
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Genomic context

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See Catsperg2 in Genome Data Viewer
Location:
7 B1; 7 17.2 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29396642..29426474, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29697217..29727049, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930432E11 gene Neighboring gene STARR-seq mESC enhancer starr_18479 Neighboring gene STARR-seq mESC enhancer starr_18480 Neighboring gene predicted gene, 45978 Neighboring gene STARR-seq mESC enhancer starr_18481 Neighboring gene STARR-seq mESC enhancer starr_18484 Neighboring gene STARR-seq mESC enhancer starr_18485 Neighboring gene predicted gene, 23103 Neighboring gene predicted gene, 38983

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein. Wang H, et al. Biol Reprod, 2009 Sep. PMID 19516020, Free PMC Article
  2. Structure of a mammalian sperm cation channel complex. Lin S, et al. Nature, 2021 Jul. PMID 34225353
  3. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Chung JJ, et al. Nat Commun, 2011 Jan 11. PMID 21224844, Free PMC Article
  4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CatSper complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CatSper complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm principal piece IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cation channel sperm-associated auxiliary subunit gamma 2
Names
CATSPER gamma subunit protein
cation channel sperm-associated protein subunit gamma 2
cation channel, sperm-associated, gamma 2
catsper channel auxiliary subunit gamma 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029714.4 → NP_083990.2  cation channel sperm-associated auxiliary subunit gamma 2 precursor

    See identical proteins and their annotated locations for NP_083990.2

    Status: VALIDATED

    Source sequence(s)
    AC112789, AK006911, AV277342, BB614579, BU938829, BY724013
    Consensus CDS
    CCDS52173.1
    UniProtKB/Swiss-Prot
    C6KI89
    Related
    ENSMUSP00000052285.4, ENSMUST00000061193.4
    Conserved Domains (1) summary
    pfam15064
    Location:7 → 973
    CATSPERG; Cation channel sperm-associated protein subunit gamma

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29396642..29426474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540413.3 → XP_006540476.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X2

    Conserved Domains (1) summary
    pfam15064
    Location:7 → 953
    CATSPERG; Cation channel sperm-associated protein subunit gamma

  2. XM_011250737.2 → XP_011249039.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X4

    Conserved Domains (1) summary
    pfam15064
    Location:7 → 937
    CATSPERG; Cation channel sperm-associated protein subunit gamma

  3. XM_006540414.3 → XP_006540477.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X6

    Conserved Domains (1) summary
    pfam15064
    Location:7 → 943
    CATSPERG; Cation channel sperm-associated protein subunit gamma

  4. XM_011250736.3 → XP_011249038.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X3

    Conserved Domains (1) summary
    pfam15064
    Location:7 → 973
    CATSPERG; Cation channel sperm-associated protein subunit gamma

  5. XM_011250738.3 → XP_011249040.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X5

    Conserved Domains (1) summary
    pfam15064
    Location:7 → 920
    CATSPERG; Cation channel sperm-associated protein subunit gamma

  6. XM_036153550.1 → XP_036009443.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X10

    Conserved Domains (1) summary
    pfam15064
    Location:56 → 753
    CATSPERG; Cation channel sperm-associated protein subunit gamma

  7. XM_006540417.4 → XP_006540480.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X9

    Conserved Domains (1) summary
    pfam15064
    Location:7 → 788
    CATSPERG; Cation channel sperm-associated protein subunit gamma

  8. XM_006540416.4 → XP_006540479.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X7

    Conserved Domains (1) summary
    pfam15064
    Location:7 → 806
    CATSPERG; Cation channel sperm-associated protein subunit gamma

  9. XM_006540412.2 → XP_006540475.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X1

    See identical proteins and their annotated locations for XP_006540475.1

    UniProtKB/Swiss-Prot
    C6KI89
    Conserved Domains (1) summary
    pfam15064
    Location:7 → 973
    CATSPERG; Cation channel sperm-associated protein subunit gamma

  10. XM_017312381.3 → XP_017167870.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X1

    UniProtKB/Swiss-Prot
    C6KI89
    Related
    ENSMUSP00000147099.2, ENSMUST00000209126.2
    Conserved Domains (1) summary
    pfam15064
    Location:7 → 973
    CATSPERG; Cation channel sperm-associated protein subunit gamma

  11. XM_011250739.3 → XP_011249041.1  cation channel sperm-associated auxiliary subunit gamma 2 isoform X8

    UniProtKB/TrEMBL
    A0A140LJ05
    Related
    ENSMUSP00000147029.2, ENSMUST00000207115.2
    Conserved Domains (1) summary
    pfam15064
    Location:7 → 973
    CATSPERG; Cation channel sperm-associated protein subunit gamma
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C6KI89.1 GenPept UniProtKB/Swiss-Prot:C6KI89

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