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Gsdma2 gasdermin A2 [ Mus musculus (house mouse) ]

Gene ID: 76758, updated on 2-Nov-2024

Summary

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Official Symbol
Gsdma2provided by MGI
Official Full Name
gasdermin A2provided by MGI
Primary source
MGI:MGI:1921490
See related
Ensembl:ENSMUSG00000017211 AllianceGenome:MGI:1921490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gsdm2; Gsdml2; GsdmA-2; 2200001G21Rik; 2210006M16Rik; 2210009F20Rik; 2210411P14Rik
Summary
Predicted to enable phospholipid binding activity and wide pore channel activity. Predicted to be involved in defense response to bacterium and pyroptotic inflammatory response. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in membrane. Is expressed in esophagus epithelium; skin; and stomach. Orthologous to human GSDMA (gasdermin A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward stomach adult (RPKM 247.5) See more
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Genomic context

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See Gsdma2 in Genome Data Viewer
Location:
11 D; 11 62.28 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98537569..98548791)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98646743..98657964)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30672 Neighboring gene serine and arginine rich splicing factor 3, pseudogene Neighboring gene gasdermin A3 Neighboring gene STARR-positive B cell enhancer ABC_E7059 Neighboring gene gasdermin A Neighboring gene STARR-seq mESC enhancer starr_30673 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98543708-98543891 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3. Runkel F, et al. Genomics, 2004 Nov. PMID 15475261
  2. Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice. Fattinger SA, et al. Proc Natl Acad Sci U S A, 2023 Nov 28. PMID 37988464, Free PMC Article
  3. Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon. Katoh M, et al. Int J Oncol, 2004 Apr. PMID 15010812
  4. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Tamura M, et al. Genomics, 2007 May. PMID 17350798
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC130173, MGC130174

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables wide pore channel activity ISO
Inferred from Sequence Orthology
more info
  
enables wide pore channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in programmed cell death IEA
Inferred from Electronic Annotation
more info
  
involved_in pyroptotic inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyroptotic inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in pyroptotic inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gasdermin-A2
Names
gasdermin-2
gasderminA-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363220.1 → NP_001350149.1  gasdermin-A2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591125, BC109335
    Consensus CDS
    CCDS36301.1
    UniProtKB/Swiss-Prot
    Q32M21, Q8CF01, Q9D810
    UniProtKB/TrEMBL
    A0A679B178
    Conserved Domains (1) summary
    pfam04598
    Location:3 → 416
    Gasdermin; Gasdermin family

  2. NM_001363221.1 → NP_001350150.1  gasdermin-A2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK008613, AL591125
    Consensus CDS
    CCDS88246.1
    Related
    ENSMUSP00000017355.6, ENSMUST00000017355.12
    Conserved Domains (1) summary
    pfam04598
    Location:19 → 249
    Gasdermin; Gasdermin family

  3. NM_029727.3 → NP_084003.2  gasdermin-A2 isoform 1

    See identical proteins and their annotated locations for NP_084003.2

    Status: VALIDATED

    Source sequence(s)
    AK008663, BC109336, BY090779
    Consensus CDS
    CCDS36301.1
    UniProtKB/Swiss-Prot
    Q32M21, Q8CF01, Q9D810
    UniProtKB/TrEMBL
    A0A679B178
    Related
    ENSMUSP00000091470.4, ENSMUST00000093938.10
    Conserved Domains (1) summary
    pfam04598
    Location:3 → 416
    Gasdermin; Gasdermin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98537569..98548791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157079.1 → XP_036012972.1  gasdermin-A2 isoform X1

    UniProtKB/TrEMBL
    A0A679B178
    Conserved Domains (2) summary
    pfam04598
    Location:24 → 254
    Gasdermin; Gasdermin family
    pfam17708
    Location:273 → 437
    Gasdermin_C; Gasdermin PUB domain

  2. XM_006534455.3 → XP_006534518.1  gasdermin-A2 isoform X1

    UniProtKB/TrEMBL
    A0A679B178
    Conserved Domains (2) summary
    pfam04598
    Location:24 → 254
    Gasdermin; Gasdermin family
    pfam17708
    Location:273 → 437
    Gasdermin_C; Gasdermin PUB domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32M21.1 GenPept UniProtKB/Swiss-Prot:Q32M21

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