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Mettl4 methyltransferase 4, N6-adenosine [ Mus musculus (house mouse) ]

Gene ID: 76781, updated on 2-Nov-2024

Summary

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Official Symbol
Mettl4provided by MGI
Official Full Name
methyltransferase 4, N6-adenosineprovided by MGI
Primary source
MGI:MGI:1924031
See related
Ensembl:ENSMUSG00000055660 AllianceGenome:MGI:1924031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HsT661; 2410198H06Rik; A730091E08Rik
Summary
Enables site-specific DNA-methyltransferase (adenine-specific) activity. Involved in negative regulation of gene expression, epigenetic. Predicted to be located in mitochondrial matrix. Predicted to be active in cytosol and nucleus. Orthologous to human METTL4 (methyltransferase 4, N6-adenosine). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 3.7), CNS E11.5 (RPKM 3.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Mettl4 in Genome Data Viewer
Location:
17 E5; 17 61.17 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (95030018..95057579, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (94722590..94750214, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9416 Neighboring gene STARR-seq mESC enhancer starr_43640 Neighboring gene predicted gene, 41655 Neighboring gene STARR-seq mESC enhancer starr_43642 Neighboring gene STARR-seq mESC enhancer starr_43643 Neighboring gene STARR-seq mESC enhancer starr_43644 Neighboring gene NDC80 homolog, kinetochore complex component pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr17:95148921-95149221 Neighboring gene STARR-positive B cell enhancer mm9_chr17:95149244-95149545 Neighboring gene STARR-positive B cell enhancer ABC_E8926 Neighboring gene predicted gene 1976 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 7 Neighboring gene STARR-positive B cell enhancer mm9_chr17:95233967-95234268 Neighboring gene STARR-positive B cell enhancer mm9_chr17:95235804-95236104 Neighboring gene signal recognition particle 19 kDa protein pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of Adipocyte Differentiation by METTL4, a 6 mA Methylase. Zhang Z, et al. Sci Rep, 2020 May 19. PMID 32427889, Free PMC Article
  2. METTL4 mediated-N6-methyladenosine promotes acute lung injury by activating ferroptosis in alveolar epithelial cells. Sang A, et al. Free Radic Biol Med, 2024 Mar. PMID 38224757
  3. An Adversarial DNA N(6)-Methyladenine-Sensor Network Preserves Polycomb Silencing. Kweon SM, et al. Mol Cell, 2019 Jun 20. PMID 30982744, Free PMC Article
  4. m(6)A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells. Wang Y, et al. Diabetes, 2020 Aug. PMID 32404350
  5. The Maternal Microbiome Programs the m(6)A Epitranscriptome of the Mouse Fetal Brain and Intestine. Xiao Z, et al. Front Cell Dev Biol, 2022. PMID 35874829, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL4 mediated-N6-methyladenosine promotes acute lung injury by activating ferroptosis in alveolar epithelial cells.
    Title: METTL4 mediated-N6-methyladenosine promotes acute lung injury by activating ferroptosis in alveolar epithelial cells.
  2. Regulation of Adipocyte Differentiation by METTL4, a 6 mA Methylase.
    Title: Regulation of Adipocyte Differentiation by METTL4, a 6 mA Methylase.
  3. It has been shown that 6methyladenine (6 mA) deposition and removal are catalyzed by the Mettl4 methyltransferase and Alkbh4 dioxygenase, respectively, and that 6mA accumulation in genic elements corresponds with transcriptional silencing.
    Title: An Adversarial DNA N(6)-Methyladenine-Sensor Network Preserves Polycomb Silencing.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables site-specific DNA-methyltransferase (adenine-specific) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables site-specific DNA-methyltransferase (adenine-specific) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables site-specific DNA-methyltransferase (adenine-specific) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression, epigenetic IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in snRNA (adenine-N6)-methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in snRNA (adenine-N6)-methylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
N(6)-adenine-specific methyltransferase METTL4
Names
N(6)-adenine-specific DNA methyltransferase METTL4
methyltransferase like 4
methyltransferase-like protein 4
snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4
NP_001344064.1
NP_001344065.1
NP_001344066.1
NP_001344067.1
NP_795891.2
XP_011245012.1
XP_036016723.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357135.2 → NP_001344064.1  N(6)-adenine-specific methyltransferase METTL4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC165075
    Consensus CDS
    CCDS29030.1
    UniProtKB/Swiss-Prot
    Q3U034
    Conserved Domains (1) summary
    cl01947
    Location:280 → 454
    MT-A70

  2. NM_001357136.2 → NP_001344065.1  N(6)-adenine-specific methyltransferase METTL4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC165075
    Consensus CDS
    CCDS29030.1
    UniProtKB/Swiss-Prot
    Q3U034
    Conserved Domains (1) summary
    cl01947
    Location:280 → 454
    MT-A70

  3. NM_001357137.2 → NP_001344066.1  N(6)-adenine-specific methyltransferase METTL4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165075
    Consensus CDS
    CCDS89172.1
    UniProtKB/TrEMBL
    A4FTY8
    Related
    ENSMUSP00000127142.3, ENSMUST00000171284.3
    Conserved Domains (1) summary
    cl01947
    Location:259 → 433
    MT-A70

  4. NM_001357138.2 → NP_001344067.1  N(6)-adenine-specific methyltransferase METTL4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165075
    Consensus CDS
    CCDS89172.1
    UniProtKB/TrEMBL
    A4FTY8
    Conserved Domains (1) summary
    cl01947
    Location:259 → 433
    MT-A70

  5. NM_176917.6 → NP_795891.2  N(6)-adenine-specific methyltransferase METTL4 isoform 1

    See identical proteins and their annotated locations for NP_795891.2

    Status: VALIDATED

    Source sequence(s)
    AC165075
    Consensus CDS
    CCDS29030.1
    UniProtKB/Swiss-Prot
    Q3U034
    Related
    ENSMUSP00000157180.2, ENSMUST00000234990.2
    Conserved Domains (1) summary
    cl01947
    Location:280 → 454
    MT-A70

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    95030018..95057579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160830.1 → XP_036016723.1  N(6)-adenine-specific methyltransferase METTL4 isoform X2

    Conserved Domains (1) summary
    cl01947
    Location:259 → 401
    MT-A70

  2. XM_011246710.3 → XP_011245012.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

    Conserved Domains (1) summary
    cl01947
    Location:280 → 422
    MT-A70

RNA

  1. XR_001782127.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U034.1 GenPept UniProtKB/Swiss-Prot:Q3U034

Gene LinkOut

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