U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Snip1 Smad nuclear interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 76793, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Snip1provided by MGI
Official Full Name
Smad nuclear interacting protein 1provided by MGI
Primary source
MGI:MGI:2156003
See related
Ensembl:ENSMUSG00000050213 AllianceGenome:MGI:2156003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410133M08Rik
Summary
Enables transcription regulator inhibitor activity. Involved in negative regulation of canonical NF-kappaB signal transduction. Is active in nucleus. Is expressed in several structures, including branchial arch; cerebral cortex; gut epithelium; metanephros; and sensory organ. Orthologous to human SNIP1 (Smad nuclear interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 7.6), CNS E11.5 (RPKM 7.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Snip1 in Genome Data Viewer
Location:
4 D2.2; 4 57.99 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124960465..124967836)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (125066672..125074043)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38472 Neighboring gene STARR-positive B cell enhancer ABC_E7987 Neighboring gene guanine nucleotide binding protein nucleolar 2 Neighboring gene dynein, axonemal, light intermediate polypeptide 1 Neighboring gene STARR-positive B cell enhancer ABC_E6215 Neighboring gene splicing factor 3a, subunit 2 pseudogene Neighboring gene MYST/Esa1-associated factor 6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration. Meng D, et al. Protein Cell, 2023 May 8. PMID 37027487, Free PMC Article
  2. Smad nuclear interacting protein 1 (SNIP1) inhibits intestinal inflammation through regulation of epithelial barrier function. Shi Y, et al. Mucosal Immunol, 2018 May. PMID 29426045
  3. LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding to SENP1 to promote intestinal fibrosis in Crohn's disease. Chen W, et al. Int J Biol Macromol, 2024 Mar. PMID 38309408
  4. SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. Kim RH, et al. J Biol Chem, 2001 Dec 7. PMID 11567019
  5. SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development. Matsui Y, et al. Nat Commun, 2023 Aug 8. PMID 37553330, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding to SENP1 to promote intestinal fibrosis in Crohn's disease.
    Title: LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding to SENP1 to promote intestinal fibrosis in Crohn's disease.
  2. these data demonstrated a novel mechanism whereby SNIP1 regulates intestinal inflammation through modulating intestinal epithelial barrier function
    Title: Smad nuclear interacting protein 1 (SNIP1) inhibits intestinal inflammation through regulation of epithelial barrier function.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription regulator inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in miRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type precatalytic spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
smad nuclear-interacting protein 1
Names
Smad nuclear interacting protein 1 Snip1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356560.1 → NP_001343489.1  smad nuclear-interacting protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK078163, AL626775, BB636252, BE336211
    Conserved Domains (2) summary
    cd00060
    Location:150 → 253
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl28310
    Location:3 → 97
    Rho; Transcription termination factor Rho [Transcription]

  2. NM_175246.5 → NP_780455.2  smad nuclear-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_780455.2

    Status: VALIDATED

    Source sequence(s)
    AK040571, AL626775, BE336211
    Consensus CDS
    CCDS18636.1
    UniProtKB/Swiss-Prot
    Q3V106, Q8BIZ4, Q8BIZ6
    Related
    ENSMUSP00000060721.7, ENSMUST00000052183.7
    Conserved Domains (2) summary
    COG1716
    Location:262 → 353
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:245 → 360
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    124960465..124967836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIZ6.1 GenPept UniProtKB/Swiss-Prot:Q8BIZ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous