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Rpl18a ribosomal protein L18A [ Mus musculus (house mouse) ]

Gene ID: 76808, updated on 28-Oct-2024

Summary

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Official Symbol
Rpl18aprovided by MGI
Official Full Name
ribosomal protein L18Aprovided by MGI
Primary source
MGI:MGI:1924058
See related
Ensembl:ENSMUSG00000045128 AllianceGenome:MGI:1924058
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2510019J09Rik
Summary
A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in postsynaptic density. Orthologous to human RPL18A (ribosomal protein L18a). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 831.5), spleen adult (RPKM 769.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rpl18a in Genome Data Viewer
Location:
8 B3.3; 8 34.38 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71347366..71350087, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70894722..70897443, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 124 Neighboring gene STARR-positive B cell enhancer ABC_E8242 Neighboring gene STARR-seq mESC enhancer starr_21801 Neighboring gene solute carrier family 5 (sodium iodide symporter), member 5 Neighboring gene STARR-positive B cell enhancer ABC_E1104 Neighboring gene microRNA 7067 Neighboring gene small nucleolar RNA, H/ACA box 68 Neighboring gene microtubule-associated protein 1S Neighboring gene microRNA 1969

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies. Tiu GC, et al. Dev Cell, 2021 Jul 26. PMID 34242585, Free PMC Article
  2. A male germ-cell-specific ribosome controls male fertility. Li H, et al. Nature, 2022 Dec. PMID 36517592
  3. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
  4. Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning. Kondrashov N, et al. Cell, 2011 Apr 29. PMID 21529712, Free PMC Article
  5. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in ribosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein eL20
Names
60S ribosomal protein L18a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029751.4 → NP_084027.1  large ribosomal subunit protein eL20

    See identical proteins and their annotated locations for NP_084027.1

    Status: VALIDATED

    Source sequence(s)
    AK161942, CJ042325
    Consensus CDS
    CCDS22386.1
    UniProtKB/Swiss-Prot
    P62717, Q3TSN0
    UniProtKB/TrEMBL
    Q3THJ0
    Related
    ENSMUSP00000058368.9, ENSMUST00000054220.10
    Conserved Domains (1) summary
    COG2157
    Location:69 → 153
    RPL20A; Ribosomal protein L20A (L18A) [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71347366..71350087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62717.1 GenPept UniProtKB/Swiss-Prot:P62717

Gene LinkOut

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