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Mtfr1l mitochondrial fission regulator 1-like [ Mus musculus (house mouse) ]

Gene ID: 76824, updated on 28-Oct-2024

Summary

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Official Symbol
Mtfr1lprovided by MGI
Official Full Name
mitochondrial fission regulator 1-likeprovided by MGI
Primary source
MGI:MGI:1924074
See related
Ensembl:ENSMUSG00000046671 AllianceGenome:MGI:1924074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam54b; 2410166I05Rik
Summary
Predicted to be involved in aerobic respiration and mitochondrial fission. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Orthologous to human MTFR1L (mitochondrial fission regulator 1 like). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in testis adult (RPKM 60.2), heart adult (RPKM 44.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mtfr1l in Genome Data Viewer
Location:
4 D3; 4 66.83 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134252866..134262698, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134525555..134535387, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4680 Neighboring gene progestin and adipoQ receptor family member VII Neighboring gene aurora kinase A and ninein interacting protein Neighboring gene STARR-positive B cell enhancer mm9_chr4:134091101-134091402 Neighboring gene selenoprotein N Neighboring gene mannosidase, alpha, class 1C, member 1 Neighboring gene microRNA 6403

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors. Maurice P, et al. Mol Cell Proteomics, 2008 Aug. PMID 18448421, Free PMC Article
  2. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. McLelland GL, et al. Elife, 2018 Apr 20. PMID 29676259, Free PMC Article
  3. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. Benleulmi-Chaachoua A, et al. J Pineal Res, 2016 Jan. PMID 26514267
  4. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
  5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitochondrial fission regulator 1-like
Names
family with sequence similarity 54, member B
protein FAM54B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256112.1 → NP_001243041.1  mitochondrial fission regulator 1-like

    See identical proteins and their annotated locations for NP_001243041.1

    Status: VALIDATED

    Source sequence(s)
    AI836704, AK145362, BY094859
    Consensus CDS
    CCDS18775.1
    UniProtKB/Swiss-Prot
    Q3UJK3, Q8BTP7, Q9CWE0
    UniProtKB/TrEMBL
    D3YW54
    Related
    ENSMUSP00000099609.4, ENSMUST00000102550.10
    Conserved Domains (1) summary
    pfam05308
    Location:9 → 250
    Mito_fiss_reg; Mitochondrial fission regulator

  2. NM_001355187.1 → NP_001342116.1  mitochondrial fission regulator 1-like

    Status: VALIDATED

    Source sequence(s)
    AI836704, AK169047, BY295153
    Consensus CDS
    CCDS18775.1
    UniProtKB/Swiss-Prot
    Q3UJK3, Q8BTP7, Q9CWE0
    UniProtKB/TrEMBL
    D3YW54
    Conserved Domains (1) summary
    pfam05308
    Location:9 → 250
    Mito_fiss_reg; Mitochondrial fission regulator

  3. NM_001355188.1 → NP_001342117.1  mitochondrial fission regulator 1-like

    Status: VALIDATED

    Source sequence(s)
    AI836704, AK169047, AL669982, BY261234, CX200239
    Consensus CDS
    CCDS18775.1
    UniProtKB/Swiss-Prot
    Q3UJK3, Q8BTP7, Q9CWE0
    UniProtKB/TrEMBL
    D3YW54
    Conserved Domains (1) summary
    pfam05308
    Location:9 → 250
    Mito_fiss_reg; Mitochondrial fission regulator

  4. NM_029759.4 → NP_084035.1  mitochondrial fission regulator 1-like

    See identical proteins and their annotated locations for NP_084035.1

    Status: VALIDATED

    Source sequence(s)
    AI836704, AK169047, BY123213
    Consensus CDS
    CCDS18775.1
    UniProtKB/Swiss-Prot
    Q3UJK3, Q8BTP7, Q9CWE0
    UniProtKB/TrEMBL
    D3YW54
    Related
    ENSMUSP00000111983.4, ENSMUST00000116279.10
    Conserved Domains (1) summary
    pfam05308
    Location:9 → 250
    Mito_fiss_reg; Mitochondrial fission regulator

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    134252866..134262698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539256.2 → XP_006539319.1  mitochondrial fission regulator 1-like isoform X1

    See identical proteins and their annotated locations for XP_006539319.1

    UniProtKB/Swiss-Prot
    Q3UJK3, Q8BTP7, Q9CWE0
    UniProtKB/TrEMBL
    D3YW54
    Related
    ENSMUSP00000117943.2, ENSMUST00000154769.8
    Conserved Domains (1) summary
    pfam05308
    Location:9 → 250
    Mito_fiss_reg; Mitochondrial fission regulator

  2. XM_006539258.3 → XP_006539321.1  mitochondrial fission regulator 1-like isoform X1

    See identical proteins and their annotated locations for XP_006539321.1

    UniProtKB/Swiss-Prot
    Q3UJK3, Q8BTP7, Q9CWE0
    UniProtKB/TrEMBL
    D3YW54
    Conserved Domains (1) summary
    pfam05308
    Location:9 → 250
    Mito_fiss_reg; Mitochondrial fission regulator
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWE0.1 GenPept UniProtKB/Swiss-Prot:Q9CWE0

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