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ZNF143 zinc finger protein 143 [ Homo sapiens (human) ]

Gene ID: 7702, updated on 3-Apr-2024

Summary

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Official Symbol
ZNF143provided by HGNC
Official Full Name
zinc finger protein 143provided by HGNC
Primary source
HGNC:HGNC:12928
See related
Ensembl:ENSG00000166478 MIM:603433; AllianceGenome:HGNC:12928
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SBF; STAF; pHZ-1
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of snRNA transcription by RNA polymerase II. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 5.8), lymph node (RPKM 4.3) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11p15.4
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (9461012..9528524)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (9546141..9612748)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9482559..9550071)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene importin 7 Neighboring gene Sharpr-MPRA regulatory region 11606 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9480928-9481563 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3126 Neighboring gene uncharacterized LOC644656 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3127 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9537259-9537799 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9551203-9551929 Neighboring gene CRISPRi-validated cis-regulatory element chr11.1006 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:9584901-9585400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3128 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9594443-9595295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3131 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4411 Neighboring gene WEE1 G2 checkpoint kinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9622289-9622842 Neighboring gene ribosomal protein L23a pseudogene 65

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF143 regulates autophagic flux to alleviate myocardial ischemia/reperfusion injury through Raptor. Rao P, et al. Cell Signal, 2022 Nov. PMID 35988805
  2. ZNF143 Expression is Associated with COPD and Tumor Microenvironment in Non-Small Cell Lung Cancer. Feng Z, et al. Int J Chron Obstruct Pulmon Dis, 2022. PMID 35400998, Free PMC Article
  3. ZNF143 is dynamically bound to a subset of its interphase sites during mitosis. Ye B, et al. Biochem Biophys Res Commun, 2020 Mar 5. PMID 31864705
  4. The Role of ZNF143 in Breast Cancer Cell Survival Through the NAD(P)H Quinone Dehydrogenase 1⁻p53⁻Beclin1 Axis Under Metabolic Stress. Paek AR, et al. Cells, 2019 Mar 30. PMID 30935019, Free PMC Article
  5. YPC-21661 and YPC-22026, novel small molecules, inhibit ZNF143 activity in vitro and in vivo. Haibara H, et al. Cancer Sci, 2017 May. PMID 28192620, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LOC644656 promotes cisplatin resistance in cervical cancer by recruiting ZNF143 and activating the transcription of E6-AP.
    Title: LOC644656 promotes cisplatin resistance in cervical cancer by recruiting ZNF143 and activating the transcription of E6-AP.
  2. ZNF143 facilitates the growth and migration of glioma cells by regulating KPNA2-mediated Hippo signalling.
    Title: ZNF143 facilitates the growth and migration of glioma cells by regulating KPNA2-mediated Hippo signalling.
  3. ATF1 promotes the malignancy of lung adenocarcinoma cells by transcriptionally regulating ZNF143 expression.
    Title: ATF1 promotes the malignancy of lung adenocarcinoma cells by transcriptionally regulating ZNF143 expression.
  4. ZNF143 regulates autophagic flux to alleviate myocardial ischemia/reperfusion injury through Raptor.
    Title: ZNF143 regulates autophagic flux to alleviate myocardial ischemia/reperfusion injury through Raptor.
  5. ZNF143 Expression is Associated with COPD and Tumor Microenvironment in Non-Small Cell Lung Cancer.
    Title: ZNF143 Expression is Associated with COPD and Tumor Microenvironment in Non-Small Cell Lung Cancer.
  6. BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) promotes lung adenocarcinoma by interacting with Zinc Finger Protein ZNF143 and regulating glycolysis.
    Title: BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) promotes lung adenocarcinoma by interacting with Zinc Finger Protein ZNF143 and regulating glycolysis.
  7. DNA methylome analysis identifies BMI-related epigenetic changes associated with non-small cell lung cancer susceptibility.
    Title: DNA methylome analysis identifies BMI-related epigenetic changes associated with non-small cell lung cancer susceptibility.
  8. ZNF143-Mediated H3K9 Trimethylation Upregulates CDC6 by Activating MDIG in Hepatocellular Carcinoma.
    Title: ZNF143-Mediated H3K9 Trimethylation Upregulates CDC6 by Activating MDIG in Hepatocellular Carcinoma.
  9. ZNF143 Suppresses Cell Apoptosis and Promotes Proliferation in Gastric Cancer via ROS/p53 Axis.
    Title: ZNF143 Suppresses Cell Apoptosis and Promotes Proliferation in Gastric Cancer via ROS/p53 Axis.
  10. LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.
    Title: LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of snRNA transcription by RNA polymerase II EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase III TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase III TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
zinc finger protein 143
Names
SPH-binding factor
hStaf
selenocysteine tRNA gene transcription-activating factor
transcriptional activator Staf
NP_001269585.1
NP_001269586.1
NP_003433.3
XP_005253178.1
XP_005253179.1
XP_011518651.1
XP_016873741.1
XP_016873742.1
XP_016873743.1
XP_016873744.1
XP_047283508.1
XP_047283509.1
XP_047283510.1
XP_047283511.1
XP_047283512.1
XP_047283513.1
XP_047283514.1
XP_047283515.1
XP_047283516.1
XP_047283517.1
XP_047283518.1
XP_054225845.1
XP_054225846.1
XP_054225847.1
XP_054225848.1
XP_054225849.1
XP_054225850.1
XP_054225851.1
XP_054225852.1
XP_054225853.1
XP_054225854.1
XP_054225855.1
XP_054225856.1
XP_054225857.1
XP_054225858.1
XP_054225859.1
XP_054225860.1
XP_054225861.1
XP_054225862.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282656.2 → NP_001269585.1  zinc finger protein 143 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AK297214, AK313330, BF515092, BG825506, CN295530
    Consensus CDS
    CCDS60720.1
    UniProtKB/TrEMBL
    E7EN86
    Related
    ENSP00000432154.1, ENST00000530463.5
    Conserved Domains (4) summary
    COG5048
    Location:263 → 321
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:312 → 339
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:298 → 413
    zf-C2H2_8; C2H2-type zinc ribbon

  2. NM_001282657.2 → NP_001269586.1  zinc finger protein 143 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AK297214, BC014458, BF515092, BG825506, CN295530
    Consensus CDS
    CCDS60721.1
    UniProtKB/TrEMBL
    E7EN86
    Related
    ENSP00000379843.3, ENST00000396597.7
    Conserved Domains (5) summary
    COG5048
    Location:233 → 291
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:208 → 230
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:282 → 309
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:268 → 383
    zf-C2H2_8; C2H2-type zinc ribbon
    cl00342
    Location:51 → 161
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

  3. NM_003442.6 → NP_003433.3  zinc finger protein 143 isoform 1

    See identical proteins and their annotated locations for NP_003433.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK297214, AW162015, BC020219, BG825506
    Consensus CDS
    CCDS7799.2
    UniProtKB/Swiss-Prot
    A8K518, B4DLY5, E7ER34, O75559, P52747, Q8WUK9
    UniProtKB/TrEMBL
    E7EN86
    Related
    ENSP00000379847.2, ENST00000396602.7
    Conserved Domains (5) summary
    COG5048
    Location:264 → 322
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:313 → 340
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:299 → 414
    zf-C2H2_8; C2H2-type zinc ribbon
    cl00342
    Location:82 → 192
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    9461012..9528524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427553.1 → XP_047283509.1  zinc finger protein 143 isoform X5

    UniProtKB/Swiss-Prot
    A8K518, B4DLY5, E7ER34, O75559, P52747, Q8WUK9

  2. XM_047427557.1 → XP_047283513.1  zinc finger protein 143 isoform X6

  3. XM_047427552.1 → XP_047283508.1  zinc finger protein 143 isoform X5

    UniProtKB/Swiss-Prot
    A8K518, B4DLY5, E7ER34, O75559, P52747, Q8WUK9

  4. XM_011520349.3 → XP_011518651.1  zinc finger protein 143 isoform X5

    See identical proteins and their annotated locations for XP_011518651.1

    UniProtKB/Swiss-Prot
    A8K518, B4DLY5, E7ER34, O75559, P52747, Q8WUK9
    UniProtKB/TrEMBL
    E7EN86
    Conserved Domains (5) summary
    COG5048
    Location:264 → 322
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:313 → 340
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:299 → 414
    zf-C2H2_8; C2H2-type zinc ribbon
    cl00342
    Location:82 → 192
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

  5. XM_047427556.1 → XP_047283512.1  zinc finger protein 143 isoform X6

  6. XM_047427559.1 → XP_047283515.1  zinc finger protein 143 isoform X7

  7. XM_005253121.2 → XP_005253178.1  zinc finger protein 143 isoform X1

    UniProtKB/TrEMBL
    E7EN86
    Conserved Domains (5) summary
    COG5048
    Location:279 → 337
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:254 → 276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:328 → 355
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:314 → 429
    zf-C2H2_8; C2H2-type zinc ribbon
    cl00342
    Location:97 → 207
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

  8. XM_005253122.2 → XP_005253179.1  zinc finger protein 143 isoform X2

    UniProtKB/TrEMBL
    E7EN86
    Conserved Domains (4) summary
    COG5048
    Location:278 → 336
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:327 → 354
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:313 → 428
    zf-C2H2_8; C2H2-type zinc ribbon

  9. XM_017018252.2 → XP_016873741.1  zinc finger protein 143 isoform X3

    UniProtKB/TrEMBL
    E7EN86

  10. XM_017018253.2 → XP_016873742.1  zinc finger protein 143 isoform X4

    UniProtKB/TrEMBL
    E7EN86

  11. XM_047427554.1 → XP_047283510.1  zinc finger protein 143 isoform X5

    UniProtKB/Swiss-Prot
    A8K518, B4DLY5, E7ER34, O75559, P52747, Q8WUK9

  12. XM_017018254.3 → XP_016873743.1  zinc finger protein 143 isoform X6

    UniProtKB/TrEMBL
    E7EN86
    Conserved Domains (4) summary
    COG5048
    Location:263 → 321
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:312 → 339
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:298 → 413
    zf-C2H2_8; C2H2-type zinc ribbon

  13. XM_047427560.1 → XP_047283516.1  zinc finger protein 143 isoform X7

  14. XM_047427555.1 → XP_047283511.1  zinc finger protein 143 isoform X5

    UniProtKB/Swiss-Prot
    A8K518, B4DLY5, E7ER34, O75559, P52747, Q8WUK9

  15. XM_017018255.2 → XP_016873744.1  zinc finger protein 143 isoform X6

    UniProtKB/TrEMBL
    E7EN86
    Conserved Domains (4) summary
    COG5048
    Location:263 → 321
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:312 → 339
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:298 → 413
    zf-C2H2_8; C2H2-type zinc ribbon

  16. XM_047427558.1 → XP_047283514.1  zinc finger protein 143 isoform X7

  17. XM_047427561.1 → XP_047283517.1  zinc finger protein 143 isoform X8

  18. XM_047427562.1 → XP_047283518.1  zinc finger protein 143 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    9546141..9612748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369870.1 → XP_054225845.1  zinc finger protein 143 isoform X1

  2. XM_054369871.1 → XP_054225846.1  zinc finger protein 143 isoform X2

  3. XM_054369872.1 → XP_054225847.1  zinc finger protein 143 isoform X3

  4. XM_054369873.1 → XP_054225848.1  zinc finger protein 143 isoform X4

  5. XM_054369881.1 → XP_054225856.1  zinc finger protein 143 isoform X6

  6. XM_054369876.1 → XP_054225851.1  zinc finger protein 143 isoform X5

  7. XM_054369877.1 → XP_054225852.1  zinc finger protein 143 isoform X5

  8. XM_054369880.1 → XP_054225855.1  zinc finger protein 143 isoform X6

  9. XM_054369884.1 → XP_054225859.1  zinc finger protein 143 isoform X7

  10. XM_054369878.1 → XP_054225853.1  zinc finger protein 143 isoform X5

  11. XM_054369875.1 → XP_054225850.1  zinc finger protein 143 isoform X6

  12. XM_054369885.1 → XP_054225860.1  zinc finger protein 143 isoform X7

  13. XM_054369879.1 → XP_054225854.1  zinc finger protein 143 isoform X5

  14. XM_054369882.1 → XP_054225857.1  zinc finger protein 143 isoform X6

  15. XM_054369883.1 → XP_054225858.1  zinc finger protein 143 isoform X7

  16. XM_054369874.1 → XP_054225849.1  zinc finger protein 143 isoform X5

  17. XM_054369886.1 → XP_054225861.1  zinc finger protein 143 isoform X8

  18. XM_054369887.1 → XP_054225862.1  zinc finger protein 143 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52747.2 GenPept UniProtKB/Swiss-Prot:P52747

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