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Arsk arylsulfatase K [ Mus musculus (house mouse) ]

Gene ID: 77041, updated on 2-Nov-2024

Summary

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Official Symbol
Arskprovided by MGI
Official Full Name
arylsulfatase Kprovided by MGI
Primary source
MGI:MGI:1924291
See related
Ensembl:ENSMUSG00000021592 AllianceGenome:MGI:1924291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ASK; 2810429K17Rik; 4833414G15Rik
Summary
Enables glucuronate-2-sulfatase activity. Predicted to be located in extracellular region and lysosome. Is expressed in aorta; genitourinary system; heart; and spinal cord. Used to study mucopolysaccharidosis. Human ortholog(s) of this gene implicated in mucopolysaccharidosis. Orthologous to human ARSK (arylsulfatase family member K). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 3.6), kidney adult (RPKM 3.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Arsk in Genome Data Viewer
Location:
13 C1; 13 40.95 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (76208829..76246744, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (76060422..76098660, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52035 Neighboring gene G protein-coupled receptor 150 Neighboring gene predicted gene, 41006 Neighboring gene predicted gene, 31161 Neighboring gene STARR-positive B cell enhancer ABC_E8536 Neighboring gene STARR-positive B cell enhancer ABC_E2413 Neighboring gene SKI3 subunit of superkiller complex Neighboring gene STARR-seq mESC enhancer starr_35057 Neighboring gene STARR-seq mESC enhancer starr_35058 Neighboring gene family with sequence similarity 81, member B Neighboring gene predicted gene, 31219

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate. Trabszo C, et al. Biochem J, 2020 Sep 18. PMID 32856704, Free PMC Article
  2. Expression patterns of sulfatase genes in the developing mouse embryo. Ratzka A, et al. Dev Dyn, 2010 Jun. PMID 20503373
  3. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Sardiello M, et al. Hum Mol Genet, 2005 Nov 1. PMID 16174644
  4. Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development. Uijtdewilligen PJE, et al. Biomed Res Int, 2018. PMID 30228991, Free PMC Article
  5. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate.
    Title: Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arylsulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arylsulfatase activity IEA
Inferred from Electronic Annotation
more info
  
enables arylsulfatase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronate-2-sulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucuronate-2-sulfatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glucuronate-2-sulfatase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronate-2-sulfatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arylsulfatase K
Names
glucuronate-2-sulfatase
NP_001347772.1
NP_001391828.1
NP_001391840.1
NP_084123.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360843.2 → NP_001347772.1  arylsulfatase K isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122242
    Conserved Domains (1) summary
    cl23718
    Location:36 → 342
    ALP_like; alkaline phosphatases and sulfatases

  2. NM_001404899.1 → NP_001391828.1  arylsulfatase K isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122242

  3. NM_001404911.1 → NP_001391840.1  arylsulfatase K isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122242

  4. NM_029847.5 → NP_084123.3  arylsulfatase K isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122242
    Consensus CDS
    CCDS49315.1
    UniProtKB/Swiss-Prot
    Q6PE11, Q8BL50, Q8BUA1, Q9CYZ0, Q9D2L1
    Related
    ENSMUSP00000158928.2, ENSMUST00000239063.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    76208829..76246744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2L1.2 GenPept UniProtKB/Swiss-Prot:Q9D2L1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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