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ZNF157 zinc finger protein 157 [ Homo sapiens (human) ]

Gene ID: 7712, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF157provided by HGNC
Official Full Name
zinc finger protein 157provided by HGNC
Primary source
HGNC:HGNC:12942
See related
Ensembl:ENSG00000147117 MIM:300024; AllianceGenome:HGNC:12942
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF22
Summary
This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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Location:
Xp11.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (47370578..47414498)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (46780444..46824376)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47229977..47273897)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 785, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:47171435-47171935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20803 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:47176727-47177364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29589 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:47181311-47181880 Neighboring gene U6 spliceosomal RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29592 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:47240535-47241034 Neighboring gene UBX domain protein 4 pseudogene Neighboring gene small nucleolar RNA, H/ACA box 11C Neighboring gene nucleophosmin 1 pseudogene 49 Neighboring gene zinc finger protein 41 Neighboring gene uncharacterized LOC124900499

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel zinc finger gene in Xp11.2. Derry JM, et al. Genomics, 1995 Nov 20. PMID 8586441
  2. An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. Thiselton DL, et al. Genomics, 2002 Apr. PMID 11944989
  3. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. Macgregor S, et al. Hum Mol Genet, 2010 Jul 1. PMID 20395239, Free PMC Article
  4. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. Oliviero G, et al. Sci Rep, 2015 Dec 21. PMID 26687479, Free PMC Article
  5. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 157
Names
zinc finger protein 22
zinc finger protein HZF22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003446.4 → NP_003437.2  zinc finger protein 157

    See identical proteins and their annotated locations for NP_003437.2

    Status: REVIEWED

    Source sequence(s)
    AL590223, AL591503
    Consensus CDS
    CCDS14278.1
    UniProtKB/Swiss-Prot
    P51786, Q96LE9
    Related
    ENSP00000366273.4, ENST00000377073.4
    Conserved Domains (6) summary
    smart00349
    Location:27 → 87
    KRAB; krueppel associated box
    COG5048
    Location:159 → 499
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220 → 240
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:470 → 492
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:27 → 66
    KRAB; KRAB box
    pfam13465
    Location:345 → 367
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    47370578..47414498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    46780444..46824376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51786.2 GenPept UniProtKB/Swiss-Prot:P51786

Gene LinkOut

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