U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF195 zinc finger protein 195 [ Homo sapiens (human) ]

Gene ID: 7748, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF195provided by HGNC
Official Full Name
zinc finger protein 195provided by HGNC
Primary source
HGNC:HGNC:12986
See related
Ensembl:ENSG00000005801 MIM:602187; AllianceGenome:HGNC:12986
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRF1; ZNFP104
Summary
This gene encodes a protein belonging to the Krueppel C2H2-type zinc-finger protein family. These family members are transcription factors that are implicated in a variety of cellular processes. This gene is located near the centromeric border of chromosome 11p15.5, next to an imprinted domain that is associated with maternal-specific loss of heterozygosity in Wilms' tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in brain (RPKM 4.9), thyroid (RPKM 4.7) and 25 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11p15.4
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (3357927..3379146, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (3403249..3424539, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3379157..3400376, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 pseudogene 1 Neighboring gene vomeronasal 1 receptor 56 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3400077-3400640 Neighboring gene tumor suppressing subtransferable candidate 2 (pseudogene) Neighboring gene olfactory receptor family 7 subfamily E member 12 pseudogene Neighboring gene Sharpr-MPRA regulatory region 4578 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3425235-3426069 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3426070-3426903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3427261-3427774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3427775-3428286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3430516-3431016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3431017-3431517 Neighboring gene family with sequence similarity 86, member A pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3078

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of a KRAB family zinc finger gene, ZNF195, mapping to chromosome band 11p15.5. Hussey DJ, et al. Genomics, 1997 Oct 15. PMID 9344677
  2. DNA microarray reveals ZNF195 and SBF1 are potential biomarkers for gemcitabine sensitivity in head and neck squamous cell carcinoma cell lines. Zhu MH, et al. Int J Clin Exp Pathol, 2014. PMID 24817947, Free PMC Article
  3. Differential display analysis of oxygen-mediated changes in gene expression in first trimester human trophoblast cells. Pak BJ, et al. Placenta, 1998 Sep. PMID 9778121
  4. An integrated physical map of 210 markers assigned to the short arm of human chromosome 11. Redeker E, et al. Genomics, 1994 Jun. PMID 7959730
  5. Multipoint analysis of human chromosome 11p15/mouse distal chromosome 7: inclusion of H19/IGF2 in the minimal WT2 region, gene specificity of H19 silencing in Wilms' tumorigenesis and methylation hyper-dependence of H19 imprinting. Dao D, et al. Hum Mol Genet, 1999 Jul. PMID 10369881

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF195 and SBF1 are potential biomarkers for gemcitabine sensitivity in head and neck squamous cell carcinoma cell lines.
    Title: DNA microarray reveals ZNF195 and SBF1 are potential biomarkers for gemcitabine sensitivity in head and neck squamous cell carcinoma cell lines.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • DKFZp666D035

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 195
Names
hypoxia-regulated factor-1
krueppel family zinc finger protein (znfp104)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032109.1 RefSeqGene

    Range
    5077..26296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130519.3 → NP_001123991.1  zinc finger protein 195 isoform 2

    See identical proteins and their annotated locations for NP_001123991.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC123788, AL833722, BC121029
    Consensus CDS
    CCDS44521.1
    UniProtKB/Swiss-Prot
    O14628
    Related
    ENSP00000005082.9, ENST00000005082.13
    Conserved Domains (3) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:202 → 606
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001130520.3 → NP_001123992.1  zinc finger protein 195 isoform 1

    See identical proteins and their annotated locations for NP_001123992.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC123788, AK290099, AL833722
    Consensus CDS
    CCDS44522.1
    UniProtKB/Swiss-Prot
    A8K234, B3KTK2, B4DEL0, C9JLY9, L7MNK2, O14628, Q0VAJ6, Q658N8, Q6ZNA9
    Related
    ENSP00000382511.4, ENST00000399602.9
    Conserved Domains (5) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:225 → 629
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:524 → 544
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:592 → 617
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001242841.2 → NP_001229770.1  zinc finger protein 195 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, uses an alternate start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC123788, AK293679, AL833722
    Consensus CDS
    CCDS55737.1
    UniProtKB/Swiss-Prot
    O14628
    Related
    ENSP00000435828.1, ENST00000526601.5
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:206 → 610
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:505 → 525
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:573 → 598
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001242842.2 → NP_001229771.1  zinc finger protein 195 isoform 5

    See identical proteins and their annotated locations for NP_001229771.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR, uses an alternate start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC123788, AK308068, AL833722
    UniProtKB/Swiss-Prot
    O14628
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:180 → 584
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:479 → 499
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:547 → 572
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001242843.2 → NP_001229772.1  zinc finger protein 195 isoform 6

    See identical proteins and their annotated locations for NP_001229772.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR, uses an alternate start codon, and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (6) has a distinct N-terminus and is shorter than isoform 1. Both variants 6 and 12 encode isoform 6.
    Source sequence(s)
    AC123788, AL833722, CX867141
    Consensus CDS
    CCDS55736.1
    UniProtKB/Swiss-Prot
    O14628
    Related
    ENSP00000387998.2, ENST00000429541.6
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:157 → 561
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:456 → 476
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:524 → 549
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001256823.2 → NP_001243752.1  zinc finger protein 195 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in its 5' UTR, uses an alternate start codon, and lacks two alternate exons but includes an additional exon that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (7) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AC123788, AL833722, BM462194
    Consensus CDS
    CCDS58111.1
    UniProtKB/TrEMBL
    E9PIN4, E9PPF8
    Related
    ENSP00000414353.2, ENST00000438262.6
    Conserved Domains (2) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    pfam01352
    Location:8 → 47
    KRAB; KRAB box

  7. NM_001256824.2 → NP_001243753.1  zinc finger protein 195 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in its 5' UTR, uses an alternate start codon, uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (8) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC123788, AL833722, DA713258
    UniProtKB/Swiss-Prot
    O14628
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:188 → 592
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:487 → 507
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:555 → 580
    zf-H2C2_2; Zinc-finger double domain

  8. NM_001256825.2 → NP_001243754.1  zinc finger protein 195 isoform 6

    See identical proteins and their annotated locations for NP_001243754.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in its 5' UTR, uses an alternate start codon, and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (6) has a distinct N-terminus and is shorter than isoform 1. Both variants 6 and 12 encode isoform 6.
    Source sequence(s)
    AC123788, AL833722, DA618142
    Consensus CDS
    CCDS55736.1
    UniProtKB/Swiss-Prot
    O14628
    Related
    ENSP00000344483.7, ENST00000343338.11
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:157 → 561
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:456 → 476
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:524 → 549
    zf-H2C2_2; Zinc-finger double domain

  9. NM_007152.5 → NP_009083.2  zinc finger protein 195 isoform 3

    See identical proteins and their annotated locations for NP_009083.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AC123788, AL833722
    Consensus CDS
    CCDS41604.1
    UniProtKB/Swiss-Prot
    O14628
    Related
    ENSP00000346613.6, ENST00000354599.10
    Conserved Domains (5) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:320 → 497
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452 → 472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:520 → 545
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_040083.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) includes two additional exons in the 5' region, and lacks two exons in the 3' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest in-frame ORF. Translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123788, AK131296, AL833722

  2. NR_046381.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) includes an additional exon in both the 5' and 3' regions, but lacks a different exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 4, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123788, AL833722, DB294374

  3. NR_046382.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) includes an additional exon in the 5' region, and lacks two exons in the 3' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest in-frame ORF. Translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123788, AL833722, DA170927, DA984929

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    3357927..3379146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    3403249..3424539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14628.2 GenPept UniProtKB/Swiss-Prot:O14628

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous