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ZNF205 zinc finger protein 205 [ Homo sapiens (human) ]

Gene ID: 7755, updated on 2-Nov-2024

Summary

Official Symbol
ZNF205provided by HGNC
Official Full Name
zinc finger protein 205provided by HGNC
Primary source
HGNC:HGNC:12996
See related
Ensembl:ENSG00000122386 MIM:603436; AllianceGenome:HGNC:12996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RhitH; Zfp13; ZNF210
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of hydrogen peroxide biosynthetic process; and positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to be located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney (RPKM 3.3), ovary (RPKM 2.9) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF205 in Genome Data Viewer
Location:
16p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3112586..3120517)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3138563..3147008)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3162587..3170518)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3139191-3139721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3140253-3140782 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3142715-3143302 Neighboring gene zinc finger and SCAN domain containing 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7114 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3151352-3152052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3154929-3155612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3155613-3156296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7118 Neighboring gene uncharacterized LOC124903629 Neighboring gene ZNF205 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3163522-3164110 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3174278-3174547 Neighboring gene ZNF213 antisense RNA 1 (head to head) Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:3177693-3178243 Neighboring gene Sharpr-MPRA regulatory region 2057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10304 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3188465-3188965 Neighboring gene zinc finger protein 213

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 205 (ZNF205) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

General protein information

Preferred Names
transcriptional repressor RHIT
Names
repressor of heat-inducible transcription
transcriptional repressor RhitH
zinc finger protein 210

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042428.2NP_001035893.1  transcriptional repressor RHIT

    See identical proteins and their annotated locations for NP_001035893.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 5' non-coding region and has a shorter 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC108134, BM924902, CB152017
    Consensus CDS
    CCDS10494.2
    UniProtKB/Swiss-Prot
    A8MZK0, D3DUB4, I0J0A3, O95201, Q9BU95
    Related
    ENSP00000219091.4, ENST00000219091.9
    Conserved Domains (6) summary
    smart00349
    Location:124168
    KRAB; krueppel associated box
    COG5048
    Location:306486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:422442
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:476498
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:124161
    KRAB; KRAB box
    pfam13465
    Location:434459
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001278158.2NP_001265087.1  transcriptional repressor RHIT

    See identical proteins and their annotated locations for NP_001265087.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate donor splice site in the 5' non-coding region and has a longer 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB672633, AF060865, BC002810
    Consensus CDS
    CCDS10494.2
    UniProtKB/Swiss-Prot
    A8MZK0, D3DUB4, I0J0A3, O95201, Q9BU95
    Related
    ENSP00000480401.1, ENST00000620094.4
    Conserved Domains (6) summary
    smart00349
    Location:124168
    KRAB; krueppel associated box
    COG5048
    Location:306486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:422442
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:476498
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:124161
    KRAB; KRAB box
    pfam13465
    Location:434459
    zf-H2C2_2; Zinc-finger double domain
  3. NM_003456.3NP_003447.2  transcriptional repressor RHIT

    See identical proteins and their annotated locations for NP_003447.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AF060865, BI826058, CB152017
    Consensus CDS
    CCDS10494.2
    UniProtKB/Swiss-Prot
    A8MZK0, D3DUB4, I0J0A3, O95201, Q9BU95
    Related
    ENSP00000371627.3, ENST00000382192.7
    Conserved Domains (6) summary
    smart00349
    Location:124168
    KRAB; krueppel associated box
    COG5048
    Location:306486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:422442
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:476498
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:124161
    KRAB; KRAB box
    pfam13465
    Location:434459
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    3112586..3120517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255558.3XP_005255615.1  transcriptional repressor RHIT isoform X1

    See identical proteins and their annotated locations for XP_005255615.1

    UniProtKB/Swiss-Prot
    A8MZK0, D3DUB4, I0J0A3, O95201, Q9BU95
    Conserved Domains (6) summary
    smart00349
    Location:124168
    KRAB; krueppel associated box
    COG5048
    Location:306486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:422442
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:476498
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:124161
    KRAB; KRAB box
    pfam13465
    Location:434459
    zf-H2C2_2; Zinc-finger double domain
  2. XM_047434601.1XP_047290557.1  transcriptional repressor RHIT isoform X1

    UniProtKB/Swiss-Prot
    A8MZK0, D3DUB4, I0J0A3, O95201, Q9BU95

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    3138563..3147008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313870.1XP_054169845.1  transcriptional repressor RHIT isoform X1

  2. XM_054313869.1XP_054169844.1  transcriptional repressor RHIT isoform X1