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Efcab6 EF-hand calcium binding domain 6 [ Mus musculus (house mouse) ]

Gene ID: 77627, updated on 2-Nov-2024

Summary

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Official Symbol
Efcab6provided by MGI
Official Full Name
EF-hand calcium binding domain 6provided by MGI
Primary source
MGI:MGI:1924877
See related
Ensembl:ENSMUSG00000022441 AllianceGenome:MGI:1924877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1672; bM150J22.2; 4931407K02Rik; 4932408N08Rik
Summary
Predicted to enable calcium ion binding activity. Involved in flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in several structures, including central nervous system; reproductive system; respiratory system; and thymus. Orthologous to human EFCAB6 (EF-hand calcium binding domain 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 41.3) See more
Orthologs
human all
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Genomic context

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See Efcab6 in Genome Data Viewer
Location:
15 E1- E2; 15 39.48 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83750913..83959226, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83866712..84075025, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene metallophosphoesterase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_39343 Neighboring gene predicted gene, 52172 Neighboring gene predicted gene, 41370 Neighboring gene STARR-seq mESC enhancer starr_39344 Neighboring gene predicted gene, 41372 Neighboring gene ribosomal protein L31, pseudogene 22 Neighboring gene sulfotransferase family 4A, member 1 Neighboring gene predicted gene, 46526 Neighboring gene patatin-like phospholipase domain containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Chen Z, et al. Cell, 2023 Nov 9. PMID 37865089, Free PMC Article
  2. In-cell structural insight into the stability of sperm microtubule doublet. Tai L, et al. Cell Discov, 2023 Nov 21. PMID 37989994, Free PMC Article
  3. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, et al. Cell, 2023 Jun 22. PMID 37295417
  4. Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells. Asadi F, et al. Front Endocrinol (Lausanne), 2018. PMID 30713523, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1672

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in flagellated sperm motility IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axonemal A tubule inner sheath IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
EF-hand calcium-binding domain-containing protein 6
Names
DJ-1-binding protein
DJBP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161628.2 → NP_001155100.1  EF-hand calcium-binding domain-containing protein 6 isoform 2

    See identical proteins and their annotated locations for NP_001155100.1

    Status: VALIDATED

    Source sequence(s)
    AL513354
    UniProtKB/Swiss-Prot
    Q6P1E8
    Related
    ENSMUST00000143592.8
    Conserved Domains (5) summary
    COG5126
    Location:66 → 242
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:767 → 826
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam08976
    Location:489 → 593
    EF-hand_11; EF-hand domain
    pfam13499
    Location:766 → 826
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:660 → 705
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_001161629.2 → NP_001155101.1  EF-hand calcium-binding domain-containing protein 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL513354
    UniProtKB/Swiss-Prot
    Q6P1E8
    Related
    ENSMUST00000144169.8
    Conserved Domains (6) summary
    PTZ00184
    Location:179 → 294
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:617 → 676
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam08976
    Location:339 → 443
    EF-hand_11; EF-hand domain
    pfam13499
    Location:616 → 676
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:364 → 417
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl20644
    Location:322 → 361
    DUF4976; Domain of unknown function (DUF4976)

  3. NM_029946.5 → NP_084222.4  EF-hand calcium-binding domain-containing protein 6 isoform 1

    See identical proteins and their annotated locations for NP_084222.4

    Status: VALIDATED

    Source sequence(s)
    AL513354, AL603867
    Consensus CDS
    CCDS27707.2
    UniProtKB/Swiss-Prot
    A6PW10, A6PW11, A6PW12, Q5DTV8, Q6P1E8, Q6PGK8, Q9D2D8
    Related
    ENSMUSP00000114909.2, ENSMUST00000156187.8
    Conserved Domains (6) summary
    PTZ00183
    Location:1344 → 1512
    PTZ00183; centrin; Provisional
    COG5126
    Location:99 → 265
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:874 → 902
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:874 → 984
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1177 → 1281
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1454 → 1514
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    83750913..83959226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521531.2 → XP_006521594.2  EF-hand calcium-binding domain-containing protein 6 isoform X1

    Conserved Domains (8) summary
    PTZ00183
    Location:1364 → 1532
    PTZ00183; centrin; Provisional
    COG5126
    Location:119 → 285
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:894 → 922
    EFh_PI-PLC; EF-hand motif [structural motif]
    cd15897
    Location:787 → 823
    EFh_PEF; EF-hand motif [structural motif]
    cl28895
    Location:894 → 1004
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl25352
    Location:787 → 952
    EFh_PEF; The penta-EF hand (PEF) family
    pfam08976
    Location:1197 → 1301
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1474 → 1534
    EF-hand_7; EF-hand domain pair

  2. XM_036159627.1 → XP_036015520.1  EF-hand calcium-binding domain-containing protein 6 isoform X3

    UniProtKB/Swiss-Prot
    A6PW10, A6PW11, A6PW12, Q5DTV8, Q6P1E8, Q6PGK8, Q9D2D8
    Conserved Domains (6) summary
    PTZ00183
    Location:1344 → 1512
    PTZ00183; centrin; Provisional
    COG5126
    Location:99 → 265
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:874 → 902
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:874 → 984
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1177 → 1281
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1454 → 1514
    EF-hand_7; EF-hand domain pair

  3. XM_017316792.3 → XP_017172281.1  EF-hand calcium-binding domain-containing protein 6 isoform X4

    Conserved Domains (8) summary
    PTZ00183
    Location:1318 → 1486
    PTZ00183; centrin; Provisional
    COG5126
    Location:73 → 239
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:848 → 876
    EFh_PI-PLC; EF-hand motif [structural motif]
    cd15897
    Location:741 → 777
    EFh_PEF; EF-hand motif [structural motif]
    cl28895
    Location:848 → 958
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl25352
    Location:741 → 906
    EFh_PEF; The penta-EF hand (PEF) family
    pfam08976
    Location:1151 → 1255
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1428 → 1488
    EF-hand_7; EF-hand domain pair

  4. XM_036159629.1 → XP_036015522.1  EF-hand calcium-binding domain-containing protein 6 isoform X7

    Conserved Domains (7) summary
    PTZ00183
    Location:1145 → 1313
    PTZ00183; centrin; Provisional
    COG5126
    Location:119 → 282
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:675 → 703
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:675 → 785
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:978 → 1082
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1255 → 1315
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:4 → 62
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  5. XM_036159628.1 → XP_036015521.1  EF-hand calcium-binding domain-containing protein 6 isoform X6

    Conserved Domains (7) summary
    PTZ00183
    Location:1146 → 1314
    PTZ00183; centrin; Provisional
    COG5126
    Location:120 → 283
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:676 → 704
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:676 → 786
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:979 → 1083
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1256 → 1316
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:4 → 62
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  6. XM_017316791.2 → XP_017172280.1  EF-hand calcium-binding domain-containing protein 6 isoform X3

    UniProtKB/Swiss-Prot
    A6PW10, A6PW11, A6PW12, Q5DTV8, Q6P1E8, Q6PGK8, Q9D2D8
    Conserved Domains (6) summary
    PTZ00183
    Location:1344 → 1512
    PTZ00183; centrin; Provisional
    COG5126
    Location:99 → 265
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:874 → 902
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:874 → 984
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1177 → 1281
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1454 → 1514
    EF-hand_7; EF-hand domain pair

  7. XM_006521533.3 → XP_006521596.1  EF-hand calcium-binding domain-containing protein 6 isoform X3

    See identical proteins and their annotated locations for XP_006521596.1

    UniProtKB/Swiss-Prot
    A6PW10, A6PW11, A6PW12, Q5DTV8, Q6P1E8, Q6PGK8, Q9D2D8
    Conserved Domains (6) summary
    PTZ00183
    Location:1344 → 1512
    PTZ00183; centrin; Provisional
    COG5126
    Location:99 → 265
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:874 → 902
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:874 → 984
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1177 → 1281
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1454 → 1514
    EF-hand_7; EF-hand domain pair

  8. XM_017316793.3 → XP_017172282.1  EF-hand calcium-binding domain-containing protein 6 isoform X5

    Conserved Domains (9) summary
    PTZ00183
    Location:1230 → 1398
    PTZ00183; centrin; Provisional
    COG5126
    Location:2 → 151
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:760 → 788
    EFh_PI-PLC; EF-hand motif [structural motif]
    cd15897
    Location:653 → 689
    EFh_PEF; EF-hand motif [structural motif]
    cl28895
    Location:760 → 870
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl25352
    Location:653 → 818
    EFh_PEF; The penta-EF hand (PEF) family
    pfam08976
    Location:1063 → 1167
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1340 → 1400
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:88 → 146
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  9. XM_017316790.1 → XP_017172279.1  EF-hand calcium-binding domain-containing protein 6 isoform X2

    Conserved Domains (8) summary
    PTZ00183
    Location:1317 → 1485
    PTZ00183; centrin; Provisional
    COG5126
    Location:73 → 239
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:847 → 875
    EFh_PI-PLC; EF-hand motif [structural motif]
    cd15897
    Location:740 → 776
    EFh_PEF; EF-hand motif [structural motif]
    cl28895
    Location:847 → 957
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl25352
    Location:740 → 905
    EFh_PEF; The penta-EF hand (PEF) family
    pfam08976
    Location:1150 → 1254
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1427 → 1487
    EF-hand_7; EF-hand domain pair

  10. XM_036159630.1 → XP_036015523.1  EF-hand calcium-binding domain-containing protein 6 isoform X8

    Conserved Domains (6) summary
    PTZ00183
    Location:1081 → 1249
    PTZ00183; centrin; Provisional
    COG5126
    Location:55 → 218
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:611 → 639
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:611 → 721
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:914 → 1018
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1191 → 1251
    EF-hand_7; EF-hand domain pair

  11. XM_036159631.1 → XP_036015524.1  EF-hand calcium-binding domain-containing protein 6 isoform X9

    Conserved Domains (5) summary
    PTZ00183
    Location:705 → 873
    PTZ00183; centrin; Provisional
    cd15898
    Location:235 → 263
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:235 → 345
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:538 → 642
    EF-hand_11; EF-hand domain
    pfam13499
    Location:815 → 875
    EF-hand_7; EF-hand domain pair

  12. XM_017316795.3 → XP_017172284.1  EF-hand calcium-binding domain-containing protein 6 isoform X10

    Conserved Domains (7) summary
    PTZ00183
    Location:630 → 798
    PTZ00183; centrin; Provisional
    cd15898
    Location:160 → 188
    EFh_PI-PLC; EF-hand motif [structural motif]
    cd15897
    Location:53 → 89
    EFh_PEF; EF-hand motif [structural motif]
    cl28895
    Location:160 → 270
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl25352
    Location:53 → 218
    EFh_PEF; The penta-EF hand (PEF) family
    pfam08976
    Location:463 → 567
    EF-hand_11; EF-hand domain
    pfam13499
    Location:740 → 800
    EF-hand_7; EF-hand domain pair
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P1E8.2 GenPept UniProtKB/Swiss-Prot:Q6P1E8

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