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Rnf170 ring finger protein 170 [ Mus musculus (house mouse) ]

Gene ID: 77733, updated on 2-Nov-2024

Summary

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Official Symbol
Rnf170provided by MGI
Official Full Name
ring finger protein 170provided by MGI
Primary source
MGI:MGI:1924983
See related
Ensembl:ENSMUSG00000013878 AllianceGenome:MGI:1924983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6720407G21Rik
Summary
Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including adult walking behavior; protein K48-linked ubiquitination; and toll-like receptor 3 signaling pathway. Predicted to be active in endoplasmic reticulum membrane. Used to study hereditary ataxia. Human ortholog(s) of this gene implicated in autosomal dominant sensory ataxia 1 and hereditary spastic paraplegia 85. Orthologous to human RNF170 (ring finger protein 170). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 4.1), frontal lobe adult (RPKM 3.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf170 in Genome Data Viewer
Location:
8 A2; 8 14.38 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26609396..26633903)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (26119368..26143875)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene hook microtubule tethering protein 3 Neighboring gene RIKEN cDNA 1700047A11 gene Neighboring gene STARR-seq mESC enhancer starr_20998 Neighboring gene calcium binding protein 39 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E879 Neighboring gene STARR-seq mESC enhancer starr_20999 Neighboring gene THAP domain containing, apoptosis associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_21000 Neighboring gene STARR-seq mESC enhancer starr_21002 Neighboring gene STARR-seq mESC enhancer starr_21003 Neighboring gene predicted gene, 31727

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Age-dependent gait abnormalities in mice lacking the Rnf170 gene linked to human autosomal-dominant sensory ataxia. Kim Y, et al. Hum Mol Genet, 2015 Dec 20. PMID 26433933
  2. E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells. Song X, et al. Cell Mol Immunol, 2020 Aug. PMID 31076723, Free PMC Article
  3. The erlin2 T65I mutation inhibits erlin1/2 complex-mediated inositol 1,4,5-trisphosphate receptor ubiquitination and phosphatidylinositol 3-phosphate binding. Wright FA, et al. J Biol Chem, 2018 Oct 5. PMID 30135210, Free PMC Article
  4. RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation. Lu JP, et al. J Biol Chem, 2011 Jul 8. PMID 21610068, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells.
    Title: E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118197

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adult walking behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proprioception ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein K48-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to temperature stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within walking behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF170
Names
RING-type E3 ubiquitin transferase RNF170
NP_001344221.1
NP_001344222.2
NP_001344223.2
NP_001344224.2
NP_084241.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357292.1 → NP_001344221.1  E3 ubiquitin-protein ligase RNF170 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC093366, AI851211, AK042063, AK162554, BC114210
    Consensus CDS
    CCDS90380.1
    UniProtKB/Swiss-Prot
    A6H618, Q3U796, Q78QX6, Q8C8S1, Q8C9I0, Q8CBG9, Q8K0H6
    Related
    ENSMUSP00000118689.2, ENSMUST00000153528.8
    Conserved Domains (2) summary
    pfam06803
    Location:185 → 218
    DUF1232; Protein of unknown function (DUF1232)
    cd16553
    Location:68 → 111
    RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins

  2. NM_001357293.2 → NP_001344222.2  E3 ubiquitin-protein ligase RNF170 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093366
    Consensus CDS
    CCDS22207.1
    UniProtKB/Swiss-Prot
    A6H618, Q3U796, Q78QX6, Q8C8S1, Q8C9I0, Q8CBG9, Q8K0H6
    Conserved Domains (2) summary
    pfam06803
    Location:203 → 236
    DUF1232; Protein of unknown function (DUF1232)
    cd16553
    Location:86 → 129
    RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins

  3. NM_001357294.2 → NP_001344223.2  E3 ubiquitin-protein ligase RNF170 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093366
    Consensus CDS
    CCDS22207.1
    UniProtKB/Swiss-Prot
    A6H618, Q3U796, Q78QX6, Q8C8S1, Q8C9I0, Q8CBG9, Q8K0H6
    Conserved Domains (2) summary
    pfam06803
    Location:203 → 236
    DUF1232; Protein of unknown function (DUF1232)
    cd16553
    Location:86 → 129
    RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins

  4. NM_001357295.2 → NP_001344224.2  E3 ubiquitin-protein ligase RNF170 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093366
    Consensus CDS
    CCDS22207.1
    UniProtKB/Swiss-Prot
    A6H618, Q3U796, Q78QX6, Q8C8S1, Q8C9I0, Q8CBG9, Q8K0H6
    Conserved Domains (2) summary
    pfam06803
    Location:203 → 236
    DUF1232; Protein of unknown function (DUF1232)
    cd16553
    Location:86 → 129
    RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins

  5. NM_029965.4 → NP_084241.2  E3 ubiquitin-protein ligase RNF170 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093366
    Consensus CDS
    CCDS22207.1
    UniProtKB/Swiss-Prot
    A6H618, Q3U796, Q78QX6, Q8C8S1, Q8C9I0, Q8CBG9, Q8K0H6
    Related
    ENSMUSP00000014022.9, ENSMUST00000014022.15
    Conserved Domains (2) summary
    pfam06803
    Location:203 → 236
    DUF1232; Protein of unknown function (DUF1232)
    cd16553
    Location:86 → 129
    RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins

RNA

  1. NR_151666.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI851211, AK153658, AK162554, BC114210

  2. NR_151667.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093366

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    26609396..26633903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CBG9.1 GenPept UniProtKB/Swiss-Prot:Q8CBG9

Gene LinkOut

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