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ZXDA zinc finger X-linked duplicated A [ Homo sapiens (human) ]

Gene ID: 7789, updated on 5-Mar-2024

Summary

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Official Symbol
ZXDAprovided by HGNC
Official Full Name
zinc finger X-linked duplicated Aprovided by HGNC
Primary source
HGNC:HGNC:13198
See related
Ensembl:ENSG00000198205 MIM:300235; AllianceGenome:HGNC:13198
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF896
Summary
This gene encodes one of two duplicated zinc finger genes on chromosome Xp11. This gene is the telomeric copy; GeneID 158586 ZXDB is the more centromeric copy. The two genes have 98% nucleotide sequence similarity, and the predicted proteins contain 10 tandem zinc finger motifs. [provided by RefSeq, Nov 2009]
Orthologs
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Genomic context

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Location:
Xp11.21
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (57905430..57910458, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (57205099..57210129, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (57931864..57936892, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MDH1 pseudogene 1 Neighboring gene uncharacterized LOC124905232 Neighboring gene Sharpr-MPRA regulatory region 7453 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20873 Neighboring gene MYCL pseudogene 2 Neighboring gene keratin 8 pseudogene 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription. Aleksandrova A, et al. Mol Cell Biochem, 2010 Apr. PMID 19777325, Free PMC Article
  2. Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies. Greig GM, et al. Hum Mol Genet, 1993 Oct. PMID 8268913
  3. The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription. Al-Kandari W, et al. J Mol Biol, 2007 Jun 22. PMID 17493635, Free PMC Article
  4. Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain. Jambunathan S, et al. Biol Chem, 2007 Sep. PMID 17696781
  5. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Tarpey PS, et al. Nat Genet, 2009 May. PMID 19377476, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of ZXD proteins in regulating MHC II transcription.
    Title: An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription.
  2. ZXDA and ZXDC form an important regulatory complex for MHC II gene transcription.
    Title: The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables C2H2 zinc finger domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger X-linked protein ZXDA
Names
zinc finger protein 896

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015974.1 RefSeqGene

    Range
    5176..10204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007156.5 → NP_009087.1  zinc finger X-linked protein ZXDA

    See identical proteins and their annotated locations for NP_009087.1

    Status: REVIEWED

    Source sequence(s)
    AL034396
    Consensus CDS
    CCDS14376.1
    UniProtKB/Swiss-Prot
    P98168, Q9UJP7
    UniProtKB/TrEMBL
    A8K9H1
    Related
    ENSP00000351530.4, ENST00000358697.6
    Conserved Domains (6) summary
    COG5048
    Location:437 → 568
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:425 → 444
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:512 → 534
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:300 → 324
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:346 → 369
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:300 → 445
    zf-C2H2_aberr; Aberrant zinc-finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    57905430..57910458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    57205099..57210129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P98168.2 GenPept UniProtKB/Swiss-Prot:P98168

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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