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Hook1 hook microtubule tethering protein 1 [ Mus musculus (house mouse) ]

Gene ID: 77963, updated on 2-Nov-2024

Summary

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Official Symbol
Hook1provided by MGI
Official Full Name
hook microtubule tethering protein 1provided by MGI
Primary source
MGI:MGI:1925213
See related
Ensembl:ENSMUSG00000028572 AllianceGenome:MGI:1925213
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
azh; A930033L17Rik
Summary
Enables actin binding activity and microtubule binding activity. Acts upstream of or within Golgi organization; cytoplasmic microtubule organization; and manchette assembly. Located in microtubule cytoskeleton. Is expressed in embryo; forelimb bud; spermatid; and testis. Orthologous to human HOOK1 (hook microtubule tethering protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 19.9), CNS E18 (RPKM 15.8) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Hook1 in Genome Data Viewer
Location:
4 C5; 4 44.17 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (95855418..95913649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (95967181..96025412)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1032 Neighboring gene predicted gene, 40206 Neighboring gene FGGY carbohydrate kinase domain containing Neighboring gene STARR-seq mESC enhancer starr_10810 Neighboring gene STARR-seq mESC enhancer starr_10811 Neighboring gene STARR-seq mESC enhancer starr_10812 Neighboring gene STARR-seq mESC enhancer starr_10813 Neighboring gene STARR-seq mESC enhancer starr_10814 Neighboring gene RIKEN cDNA 9530080O11 gene Neighboring gene STARR-positive B cell enhancer ABC_E1647 Neighboring gene STARR-seq mESC enhancer starr_10816 Neighboring gene STARR-seq mESC enhancer starr_10817 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 13 Neighboring gene STARR-seq mESC enhancer starr_10818 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 6 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Offspring from normal mouse oocytes injected with sperm heads from the azh/azh mouse display more severe sperm tail abnormalities than the original mutant. Akutsu H, et al. Biol Reprod, 2001 Jan. PMID 11133681
  2. Structural and biochemical features of fractionated spermatid manchettes and sperm axonemes of the azh/azh mutant mouse. Mochida K, et al. Mol Reprod Dev, 1999 Apr. PMID 10092124
  3. Deficiency in fertilization by morphologically abnormal sperm produced by azh mutant mice. Meistrich ML, et al. Mol Reprod Dev, 1994 Jan. PMID 8129933
  4. Abnormal manchette development in spermatids of azh/azh mutant mice. Meistrich ML, et al. Am J Anat, 1990 May. PMID 2346121
  5. Linkage of manchette microtubules to the nuclear envelope and observations of the role of the manchette in nuclear shaping during spermiogenesis in rodents. Russell LD, et al. Am J Anat, 1991 Oct. PMID 1759685

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein homeostasis maintained by HOOK1 levels promotes the tumorigenic and stemness properties of ovarian cancer cells through reticulum stress and autophagy.
    Title: Protein homeostasis maintained by HOOK1 levels promotes the tumorigenic and stemness properties of ovarian cancer cells through reticulum stress and autophagy.
  2. Hook1 is a binding partner of Ccdc181.
    Title: Ccdc181 is a microtubule-binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia.
  3. Single-molecule motility assays using total internal reflection fluorescence microscopy indicate that both Hook1 and Hook3 effectively activate cytoplasmic dynein, inducing longer run lengths and higher velocities than the previously characterized dynein activator bicaudal D2 (BICD2).
    Title: Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction.
  4. Multiple samples of ejaculated spermatozoa from normal fertile C57BL/6 and infertile Hook1/Hook1 (formerly known as azh/azh) mutant males from uteri after mating.
    Title: Preservation of ejaculated mouse spermatozoa from fertile C57BL/6 and infertile Hook1/Hook1 mice collected from the uteri of mated females.
  5. azh mutation is due to a deletion of exons 10 and 11 in the murine Hook1 gene leading to a non-functional protein. Our results indicate that loss of Hook1 function results in ectopic positioning of microtubular structures within the spermatid
    Title: The Hook1 gene is non-functional in the abnormal spermatozoon head shape (azh) mutant mouse.
  6. Hook1 and Ankyrin G are co-locolized, Hook1 also localizes to additional regions of the cell devoid of Ankyrin G where it interacts with other proteins.
    Title: Elevation of Hook1 in a disease model of Batten disease does not affect a novel interaction between Ankyrin G and Hook1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Radiation induced (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton-dependent intracellular transport IEA
Inferred from Electronic Annotation
more info
  
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in early endosome to late endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lysosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome organization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within manchette assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of FHF complex ISO
Inferred from Sequence Orthology
more info
  
part_of FHF complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of HOPS complex IEA
Inferred from Electronic Annotation
more info
  
part_of HOPS complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein Hook homolog 1
Names
abnormal spermatozoon head shape
hook homolog 1
mHK1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030014.2 → NP_084290.1  protein Hook homolog 1

    See identical proteins and their annotated locations for NP_084290.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061688
    Consensus CDS
    CCDS18367.1
    UniProtKB/Swiss-Prot
    Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6
    Related
    ENSMUSP00000030306.8, ENSMUST00000030306.14
    Conserved Domains (3) summary
    pfam05622
    Location:14 → 720
    HOOK; HOOK protein
    pfam11221
    Location:175 → 210
    Med21; Subunit 21 of Mediator complex
    cl19219
    Location:502 → 584
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    95855418..95913649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503488.4 → XP_006503551.1  protein Hook homolog 1 isoform X3

    Conserved Domains (1) summary
    pfam05622
    Location:14 → 546
    HOOK; HOOK protein

  2. XM_006503487.4 → XP_006503550.1  protein Hook homolog 1 isoform X2

    Conserved Domains (1) summary
    pfam05622
    Location:14 → 534
    HOOK; HOOK protein

  3. XM_030253920.2 → XP_030109780.1  protein Hook homolog 1 isoform X1

    Conserved Domains (1) summary
    pfam05622
    Location:1 → 678
    HOOK; HOOK protein

RNA

  1. XR_001784219.2 RNA Sequence

  2. XR_001784220.2 RNA Sequence

  3. XR_376377.4 RNA Sequence

  4. XR_376374.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIL5.2 GenPept UniProtKB/Swiss-Prot:Q8BIL5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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