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Nuak1 NUAK family, SNF1-like kinase, 1 [ Mus musculus (house mouse) ]

Gene ID: 77976, updated on 28-Oct-2024

Summary

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Official Symbol
Nuak1provided by MGI
Official Full Name
NUAK family, SNF1-like kinase, 1provided by MGI
Primary source
MGI:MGI:1925226
See related
Ensembl:ENSMUSG00000020032 AllianceGenome:MGI:1925226
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Omphk1; B230104P22Rik
Summary
Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation; regulation of cell adhesion; and regulation of cellular senescence. Predicted to be located in cytoplasm; microtubule cytoskeleton; and nuclear lumen. Is expressed in several structures, including alimentary system; cardiovascular system; embryo ectoderm; nervous system; and renal cortex. Human ortholog(s) of this gene implicated in uterine fibroid. Orthologous to human NUAK1 (NUAK family kinase 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in CNS E14 (RPKM 10.9), CNS E18 (RPKM 10.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Nuak1 in Genome Data Viewer
Location:
10 C1; 10 41.42 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (84206764..84282028, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (84370900..84440668, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5425 Neighboring gene predicted gene, 46201 Neighboring gene RIKEN cDNA 4930463O16 gene Neighboring gene predicted gene, 34405 Neighboring gene transcription factor E3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Enhanced Expression of ARK5 in Hepatic Stellate Cell and Hepatocyte Synergistically Promote Liver Fibrosis. You Y, et al. Int J Mol Sci, 2022 Oct 28. PMID 36361872, Free PMC Article
  2. NUAK1 promotes organ fibrosis via YAP and TGF-β/SMAD signaling. Zhang T, et al. Sci Transl Med, 2022 Mar 23. PMID 35320001
  3. Muscle-specific knock-out of NUAK family SNF1-like kinase 1 (NUAK1) prevents high fat diet-induced glucose intolerance. Inazuka F, et al. J Biol Chem, 2012 May 11. PMID 22418434, Free PMC Article
  4. Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Liu L, et al. Nature, 2012 Mar 28. PMID 22460906
  5. High NUAK1 expression correlates with poor prognosis and involved in NSCLC cells migration and invasion. Chen P, et al. Exp Lung Res, 2013 Feb. PMID 23215946

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions.
    Title: The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions.
  2. Enhanced Expression of ARK5 in Hepatic Stellate Cell and Hepatocyte Synergistically Promote Liver Fibrosis.
    Title: Enhanced Expression of ARK5 in Hepatic Stellate Cell and Hepatocyte Synergistically Promote Liver Fibrosis.
  3. NUAK1 promotes organ fibrosis via YAP and TGF-beta/SMAD signaling.
    Title: NUAK1 promotes organ fibrosis via YAP and TGF-β/SMAD signaling.
  4. Loss of LKB1-NUAK1 signalling enhances NF-kappaB activity in a spheroid model of high-grade serous ovarian cancer.
    Title: Loss of LKB1-NUAK1 signalling enhances NF-κB activity in a spheroid model of high-grade serous ovarian cancer.
  5. High-throughput kinase inhibitor screening reveals roles for Aurora and Nuak kinases in neurite initiation and dendritic branching.
    Title: High-throughput kinase inhibitor screening reveals roles for Aurora and Nuak kinases in neurite initiation and dendritic branching.
  6. Identification of a nuclear localization signal and importin beta members mediating NUAK1 nuclear import inhibited by oxidative stress.
    Title: Identification of a nuclear localization signal and importin beta members mediating NUAK1 nuclear import inhibited by oxidative stress.
  7. NUAK1 haploinsufficiency impairs mouse cortical development.
    Title: Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice.
  8. The findings define the PI3K/NUAK1/MYPT1/MLCP axis as a critical pathway to regulate actomyosin contractility in endothelial cells, supporting vascular patterning and expansion through the control of cell rearrangement.
    Title: Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility.
  9. Knockdown of ARK5 expression remarkably suppressed Gastric Cancer cells invasion and metastasis via regulating epithelial-mesenchymal transition, rather than proliferation in vitro and in vivo.
    Title: Knockdown of ARK5 Expression Suppresses Invasion and Metastasis of Gastric Cancer.
  10. Nuak1 haploinsufficiency rescued the phenotypes of a tauopathy mouse model.
    Title: Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC90816

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NUAK family SNF1-like kinase 1
Names
AMPK-related protein kinase 5
ZNUAK family, SNF1-like kinase, 1
omphalocele kinase 1
NP_001004363.1
XP_011241905.1
XP_036011997.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004363.2 → NP_001004363.1  NUAK family SNF1-like kinase 1

    See identical proteins and their annotated locations for NP_001004363.1

    Status: VALIDATED

    Source sequence(s)
    AC150314, AI450794, BB808457, BC082328, CF534664, CJ106400, CJ247195
    Consensus CDS
    CCDS24079.1
    UniProtKB/Swiss-Prot
    Q641K5, Q6I6D6, Q8CGE1
    Related
    ENSMUSP00000020220.9, ENSMUST00000020220.15
    Conserved Domains (2) summary
    smart00220
    Location:56 → 307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14073
    Location:54 → 307
    STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    84206764..84282028 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156104.1 → XP_036011997.1  NUAK family SNF1-like kinase 1 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 210
    PKc_like; Protein Kinases, catalytic domain

  2. XM_011243603.4 → XP_011241905.1  NUAK family SNF1-like kinase 1 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1 → 175
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q641K5.1 GenPept UniProtKB/Swiss-Prot:Q641K5

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