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Cutal cutA divalent cation tolerance homolog-like [ Mus musculus (house mouse) ]

Gene ID: 77996, updated on 28-Oct-2024

Summary

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Official Symbol
Cutalprovided by MGI
Official Full Name
cutA divalent cation tolerance homolog-likeprovided by MGI
Primary source
MGI:MGI:1925246
See related
Ensembl:ENSMUSG00000026870 AllianceGenome:MGI:1925246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D730039F16Rik
Summary
Predicted to enable copper ion binding activity. Is expressed in renal cortex. Orthologous to human CUTALP (cutA divalent cation tolerance like, pseudogene). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in liver adult (RPKM 20.4), colon adult (RPKM 20.1) and 9 other tissues See more
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Genomic context

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See Cutal in Genome Data Viewer
Location:
2 B; 2 23.01 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34764408..34782145)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34874396..34892133)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene beta-1,3-galactosyltransferase 9 Neighboring gene STARR-seq mESC enhancer starr_04268 Neighboring gene STARR-seq mESC enhancer starr_04269 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 Neighboring gene STARR-positive B cell enhancer ABC_E3369 Neighboring gene PHD finger protein 19 Neighboring gene STARR-positive B cell enhancer ABC_E1003 Neighboring gene predicted gene, 24905

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  2. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
cutA divalent cation tolerance homolog-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308024.1 → NP_001294953.1  cutA divalent cation tolerance homolog-like isoform 2

    See identical proteins and their annotated locations for NP_001294953.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK033810, AK085616
    Consensus CDS
    CCDS79783.1
    UniProtKB/TrEMBL
    A0A0J9YUN0
    Related
    ENSMUSP00000144258.2, ENSMUST00000028228.6
    Conserved Domains (1) summary
    pfam03091
    Location:54 → 107
    CutA1; CutA1 divalent ion tolerance protein

  2. NM_030021.3 → NP_084297.1  cutA divalent cation tolerance homolog-like isoform 1

    See identical proteins and their annotated locations for NP_084297.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK033810, AK085616
    Consensus CDS
    CCDS15954.1
    UniProtKB/TrEMBL
    Q9D1U5
    Related
    ENSMUSP00000108691.3, ENSMUST00000113068.9
    Conserved Domains (1) summary
    pfam03091
    Location:54 → 151
    CutA1; CutA1 divalent ion tolerance protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    34764408..34782145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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